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Correlation of quantitative sensorimotor tractography with clinical grade of cerebral palsy

  • Paediatric Neuroradiology
  • Published:
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Abstract

Introduction

The purpose of this study was to determine whether tract-specific diffusion tensor imaging measures in somatosensory and motor pathways correlate with clinical grades as defined using the Gross Motor Function Classification System (GMFCS) in cerebral palsy (CP) children.

Methods

Quantitative diffusion tensor tractography was performed on 39 patients with spastic quadriparesis (mean age = 8 years) and 14 age/sex-matched controls. All patients were graded on the basis of GMFCS scale into grade II (n = 12), grade IV (n = 22), and grade V (n = 5) CP and quantitative analysis reconstruction of somatosensory and motor tracts performed.

Results

Significant inverse correlation between clinical grade and fractional anisotropy (FA) was observed in both right and left motor and sensory tracts. A significant direct correlation of mean diffusivity values from both motor and sensory tracts was also observed with clinical grades. Successive decrease in FA values was observed in all tracts except for left motor tracts moving from age/sex-matched controls to grade V through grades II and IV.

Conclusion

We conclude that white matter tracts from both the somatosensory and the motor cortex play an important role in the pathophysiology of motor disability in patients with CP.

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Acknowledgements

This work was funded by the Department of Science and Technology, New Delhi, India, grant no. SR/SO/HS/0125/2007.

Conflict of interest statement

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India

    Richa Trivedi & Rakesh K. Gupta

  2. Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, India

    Shruti Agarwal & Ram K. S. Rathore

  3. Pediatric Orthopedic Surgery unit, Bhargava Nursing Home, Lucknow, India

    Vipul Shah

  4. Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Puneet Goyel

  5. Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Vimal K. Paliwal

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  1. Richa Trivedi
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  2. Shruti Agarwal
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  3. Vipul Shah
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  4. Puneet Goyel
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  5. Vimal K. Paliwal
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  6. Ram K. S. Rathore
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  7. Rakesh K. Gupta
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Correspondence to Rakesh K. Gupta.

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Trivedi, R., Agarwal, S., Shah, V. et al. Correlation of quantitative sensorimotor tractography with clinical grade of cerebral palsy. Neuroradiology 52, 759–765 (2010). https://doi.org/10.1007/s00234-010-0703-8

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  • DOI: https://doi.org/10.1007/s00234-010-0703-8

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