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In vivo hemodynamic analysis of intracranial aneurysms obtained by magnetic resonance fluid dynamics (MRFD) based on time-resolved three-dimensional phase-contrast MRI

  • Interventional Neuroradiology
  • Published:
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Abstract

Introduction

Hemodynamics is thought to play a very important role in the initiation, growth, and rupture of intracranial aneurysms. The purpose of our study was to perform in vivo hemodynamic analysis of unruptured intracranial aneurysms of magnetic resonance fluid dynamics using time-resolved three-dimensional phase-contrast MRI (4D-Flow) at 1.5 T and to analyze relationships between hemodynamics and wall shear stress (WSS) and oscillatory shear index (OSI).

Methods

This study included nine subjects with 14 unruptured aneurysms. 4D-Flow was performed by a 1.5-T magnetic resonance scanner with a head coil. We calculated in vivo streamlines, WSS, and OSI of intracranial aneurysms based on 4D-Flow with our software. We evaluated the number of spiral flows in the aneurysms and compared the differences in WSS or OSI between the vessel and aneurysm and between whole aneurysm and the apex of the spiral flow.

Results

3D streamlines, WSS, and OSI distribution maps in arbitrary direction during the cardiac phase were obtained for all intracranial aneurysms. Twelve aneurysms had one spiral flow each, and two aneurysms had two spiral flows each. The WSS was lower and the OSI was higher in the aneurysm compared to the vessel. The apex of the spiral flow had a lower WSS and higher OSI relative to the whole aneurysm.

Conclusion

Each intracranial aneurysm in this study had at least one spiral flow. The WSS was lower and OSI was higher at the apex of the spiral flow than the whole aneurysmal wall.

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Acknowledgments

This study was supported by the grant from the Information-Technology Promotion Agency, Japan.

Conflict of interest statement

Dr. H. Isoda receives research funds from the Renaissance of Technology Corporation.

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Authors and Affiliations

  1. Department of Radiology, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan

    Haruo Isoda, Hiroyasu Takeda, Shuhei Yamashita, Yasuo Takehara & Harumi Sakahara

  2. Renaissance of Technology Corporation, 1-4-10 Shinmiyakoda Kitaku, Hamamatsu, Shizuoka, 431-2103, Japan

    Yasuhide Ohkura & Takashi Kosugi

  3. GE Healthcare Japan, 4-7-127 Asahigaoka Hino, Tokyo, 191-0065, Japan

    Masaya Hirano

  4. Department of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan

    Hisaya Hiramatsu & Hiroki Namba

  5. Department of Radiology, Radiological Sciences Laboratory, Stanford University School of Medicine, Stanford, 94305-5488, CA, USA

    Marcus T. Alley, Roland Bammer & Norbert J. Pelc

Authors
  1. Haruo Isoda
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  2. Yasuhide Ohkura
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  3. Takashi Kosugi
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  4. Masaya Hirano
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  5. Hiroyasu Takeda
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  6. Hisaya Hiramatsu
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  7. Shuhei Yamashita
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  8. Yasuo Takehara
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  9. Marcus T. Alley
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  10. Roland Bammer
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  11. Norbert J. Pelc
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  12. Hiroki Namba
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  13. Harumi Sakahara
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Corresponding author

Correspondence to Haruo Isoda.

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Animation 1

3D streamlines of a right BA-SCA aneurysm. 3D streamlines of a BA-SCA aneurysm demonstrate that the aneurysm has spiral flow with its apex at its right caudal aspect of the aneurysm and has the low flow velocities at the apex. (M1V 1871 kb)

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Isoda, H., Ohkura, Y., Kosugi, T. et al. In vivo hemodynamic analysis of intracranial aneurysms obtained by magnetic resonance fluid dynamics (MRFD) based on time-resolved three-dimensional phase-contrast MRI. Neuroradiology 52, 921–928 (2010). https://doi.org/10.1007/s00234-009-0635-3

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  • DOI: https://doi.org/10.1007/s00234-009-0635-3

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