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Hemodynamic analysis of intracranial aneurysms using phase-contrast magnetic resonance imaging and computational fluid dynamics

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Abstract

Additional hemodynamic parameters are highly desirable in the clinical management of intracranial aneurysm rupture as static medical images cannot demonstrate the blood flow within aneurysms. There are two ways of obtaining the hemodynamic information—by phase-contrast magnetic resonance imaging (PCMRI) and computational fluid dynamics (CFD). In this paper, we compared PCMRI and CFD in the analysis of a stable patient’s specific aneurysm. The results showed that PCMRI and CFD are in good agreement with each other. An additional CFD study of two stable and two ruptured aneurysms revealed that ruptured aneurysms have a higher statistical average blood velocity, wall shear stress, and oscillatory shear index (OSI) within the aneurysm sac compared to those of stable aneurysms. Furthermore, for ruptured aneurysms, the OSI divides the positive and negative wall shear stress divergence at the aneurysm sac.

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Acknowledgements

The project was supported by the Independent Research Fund of Tsinghua University (Grant 20141081265).

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    Authors and Affiliations

    1. Beijing Huaxin Hospital (First Affiliated Hospital of Tsinghua University), Beijing, 100016, China

      Xuemei Zhao

    2. Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, 100084, China

      Rui Li & Yu Chen

    3. Division of Neurosurgery, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

      Sheau Fung Sia

    4. Medical Center, Tsinghua University, Beijing, 100084, China

      Donghai Li & Yu Zhang

    5. Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China

      Aihua Liu

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    1. Xuemei Zhao
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    Correspondence to Yu Zhang.

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    Xuemei Zhao and Rui Li have contributed equally to this paper.

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    Zhao, X., Li, R., Chen, Y. et al. Hemodynamic analysis of intracranial aneurysms using phase-contrast magnetic resonance imaging and computational fluid dynamics. Acta Mech. Sin. 33, 472–483 (2017). https://doi.org/10.1007/s10409-017-0636-0

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    • DOI: https://doi.org/10.1007/s10409-017-0636-0

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