Abstract
Objective. To determine the patterns of consumption in calcium channel blockers (CCB) groups in the Czech Republic between 1992 and 1999 and make a comparison with selected countries.
Methods. This was part of a drug utilization study using WHO methodology [Anatomical Therapeutic Chemical classification/defined daily doses (ATC/DDD)]. The wholesale data collected by drug distributors were used. Utilization was calculated as the DDDs for 1000 inhabitants per day. In focus was the consumption of short-acting nifedipine. Comparison with wholesale data from Finland, Norway, Germany and Australia was made.
Results. There was a decreasing tendency to use short-acting nifedipine in the Czech Republic over the period 1993–1999. Four years after publication of warning evidence, short-acting nifedipine still accounted for 23% of all calcium channel blockers in our country. The abundance of second-generation CCBs increased from less than 1% in 1993 to 43% in 1999. The consumption of short-acting nifedipine in the Czech Republic and Germany is probably three times more frequent than in Nordic countries and Australia.
Conclusions. Consumption of short-acting nifedipine in the Czech Republic 4 years after recognition of its risks still remains very high. This suggests that implementation of clinical trial results to clinical practice is very slow and ineffective.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Accepted in revised form: 6 May 2002
Electronic Publication
Rights and permissions
About this article
Cite this article
Dolezal, T., Nemecek, K. & Krsiak, M. Trends in consumption of calcium channel blockers in the Czech Republic during 1993–1999 and comparison with selected countries: drug utilization study. Eur J Clin Pharmacol 58, 477–478 (2002). https://doi.org/10.1007/s00228-002-0489-7
Received:
Issue Date:
DOI: https://doi.org/10.1007/s00228-002-0489-7