Abstract.
Female birds model a type of woven bone prior to egg laying which is known as medullary bone. Medullary bone modeling is estrogen dependent and in the female fowl coincides with a decrease in cancellous bone volume. Medullary bone modeling was induced in male laying-strain fowl by the administration of estrogen and prevented in females by the administration of tamoxifen. In estrogen-treated males, medullary bone modeling was accompanied by cancellous bone loss; cancellous bone volume was significantly lower than in control males (P < 0.001). In females, the prevention of medullary bone modeling by tamoxifen treatment resulted in significantly higher cancellous bone volumes than in control females (P < 0.001). Estrogen therefore appears to play a role in cancellous bone loss in the fowl.
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Received: 29 April 1997 / Accepted: 3 September 1997
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Wilson, S., Thorp, B. Estrogen and Cancellous Bone Loss in the Fowl. Calcif Tissue Int 62, 506–511 (1998). https://doi.org/10.1007/s002239900470
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DOI: https://doi.org/10.1007/s002239900470