Skip to main content

Advertisement

SpringerLink
Log in

Effects of moderate endurance exercise on calcium, parathyroid hormone, and markers of bone metabolism in young women

  • Clinical Investigations
  • Published:
Calcified Tissue International Aims and scope Submit manuscript

Abstract

We investigated the short-term (1 hour-3 days) effects of a 45 minute run on calcium, parathyroid hormone, the carboxyterminal propeptide of type I procollagen (PICP), and the immunoactive carboxyterminal telopeptide of type I collagen in serum (ICTP) in young females. Fourteen healthy young women, aged 25.2 ± 0.6 years (mean ± SEM) with regular menstruations, participated. The test was outdoor jogging for 45 minutes at an intensity of 50% of VO2 max. Blood samples were collected 15 minutes before the test and 1, 24, and 72 hours after the test. The measured values were adjusted for changes in plasma volume. A significant decrease of ionized calcium was observed at 1 hour (P < 0.001) and 72 hours (P < 0.05) and a significant increase of parathyroid hormone (PTH) was noted 24 (P < 0.01) and 72 hours (P < 0.05) after the test. A significant decrease of PICP at 1 hour (P < 0.05) was followed by an increase after 24 (P < 0.01) and 72 hours (P < 0.001) and a significant increase in ICTP was noted at 24 and 72 hours (P < 0.05). A strong positive correlation was found between serum levels of PICP and ICTP (r = 0.55–0.84; P < 0.05) throughout the experiment. In conclusion, young females showed biochemical signs of increased bone collagen turnover and altered homeostasis of calcium and PTH after a single bout of moderate endurance exercise.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Woo S, Knei S, Amiel D (1981) The effect of prolonged physical training on the properties of long bone: a study of Wolff’s law. J Bone Joint Surg 63A:780–787

    Google Scholar 

  2. Frost HM (1992) The role of changes in mechanical usage set points in the pathogenesis of osteoporosis. J Bone Miner Res 7:253–261

    PubMed  CAS  Google Scholar 

  3. Lanyon LE (1992) Control of bone architecture by functioning loading. J Bone Miner Res 7(suppl 2):S369-S375

    PubMed  Google Scholar 

  4. Snow-Harter C, Marcus R (1989) Exercise and regulation of bone mass. Bone 6:45–48

    Article  Google Scholar 

  5. Nilsson BE, Westlin NE (1971) Bone density in athletes. Clin Orthop 77:179–182

    PubMed  CAS  Google Scholar 

  6. Krølner B, Toft B, Tøndevold E (1983) Physical exercise as prophylaxis against involutional vertebral bone loss: a controlled trial. Clin Sci 64:541–546

    PubMed  Google Scholar 

  7. Snow-Harter C, Bouxsein M, Lewis BT, Carter DR, Marcus R (1992) Effects of resistance and endurance exercise on bone mineral status of young women: a randomized exercise intervention trial. J Bone Miner Res 7:761–769

    Article  PubMed  CAS  Google Scholar 

  8. Taaffe DR, Snow-Harter C, Connolly DA, Robinson TL, Brown MD, Marcus R (1995) Differential effects of swimming versus weight-bearing activity on bone mineral status of eumenorrheic athletes. J Bone Miner Res 10:586–593

    Article  PubMed  CAS  Google Scholar 

  9. Friedlander AL, Genant HK, Sadowsky S, Byl NN, Glüer C-C (1995) A two-year program of aerobic and weight training enhances bone mineral density of young women. J Bone Miner Res 10:574–585

    PubMed  CAS  Google Scholar 

  10. Krølner B, Toft B (1983) Vertebral bone loss: an unheeded side effect of therapeutic bed rest. Clin Sci 64:537–540

    PubMed  Google Scholar 

  11. Law MR, Wald NJ, Meade TW (1991) Strategies for prevention of osteoporosis and hip fracture. BMJ 303:453–459

    Article  PubMed  CAS  Google Scholar 

  12. Sandler RB, Cauley JA, Hom DL, Sashin D, Kriska AM (1987) The effects of walking on the cross-sectional dimensions of the radius in postmenopausal women. Calcif Tissue Int 41:65–69

    Article  PubMed  CAS  Google Scholar 

  13. Ayalon J, Simkin A, Leichter J, Raifmann S (1987) Dynamic bone-loading exercises for postmenopausal women. Arch Phys Med Rehabil 68:280–283

    PubMed  CAS  Google Scholar 

  14. Henderson SA, Graham HK, Mollan RAB, Riddoch C, Sheridan B, Johnston H (1989) Calcium homeostasis and exercise. Int Orthop 13:69–73

    Article  PubMed  CAS  Google Scholar 

  15. Ljunghall S, Joborn H, Roxin LE, Rastad J, Wide L, Åkerstrøm G (1986) Prolonged low-intensity exercise raises the serum parathyroid hormone levels. Clin Endocrinol 25:535–542

    Article  CAS  Google Scholar 

  16. Salvesen H, Johansson AG, Foxdal P, Wide L, Piehl-Aulin K, Ljunghall S (1994) Intact serum parathyroid hormone levels increase during running exercise in well-trained men. Calcif Tissue Int 54:256–261

    Article  PubMed  CAS  Google Scholar 

  17. McSheehy PM, Chambers TJ (1986) Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoclastic bone resorption. Endocrinology 119:1654–1659

    PubMed  CAS  Google Scholar 

  18. Jerome CP (1994) Anabolic effect of high doses of human parathyroid hormone (1–38) in mature intact female rats. J Bone Miner Res 9:933–942

    PubMed  CAS  Google Scholar 

  19. Hodsman AB, Fraher LJ, Ostbye T, Adachi JD, Steer BM (1993) An evaluation of several biochemical markers for bone formation and resorption in a protocol utilizing cyclical parathyroid hormone and calcitonin therapy for osteoporosis. J Clin Invest 91:1138–1148

    Article  PubMed  CAS  Google Scholar 

  20. Eriksen EF, Charles P, Meisen F, Mosekilde L, Risteli L, Risteli J (1993) Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. J Bone Miner Res 8:127–132

    Article  PubMed  CAS  Google Scholar 

  21. Charles P, Mosekilde L, Risteli L, Risteli J, Eriksen EF (1994) Assessment of bone remodeling using biochemical indicators of type I collagen synthesis and degradation: relation to calcium kinetics. Bone Miner 24:81–94

    Article  PubMed  CAS  Google Scholar 

  22. Mellko J, Niemi S, Risteli L, Risteli J (1990) Radioimmuno-assay of the carboxyterminal propeptide of human type I procollagen. Clin Chem 36:1328–1332

    Google Scholar 

  23. Risteli J, Melkko J, Niemi S, Risteli L (1991) Use of a marker of collagen formation in osteoporosis studies. Calcif Tissue Int 49(suppl):S24-S25

    Article  PubMed  Google Scholar 

  24. Kristoffersson A, Hultdin J, Holmlund I, Thorsen K, Lorentzon R (1995) Effects of short-term maximal work on plasma calcium, parathyroid hormone, osteocalcin and biochemical markers of collagen metabolism. Int J Sports Med 16:145–149

    Article  PubMed  CAS  Google Scholar 

  25. Salvesen H, Piehl-Aulin K, Ljunghall S (1994) Change in levels of the carboxyterminal propeptide of type I procollagen, the carboxyterminal cross-linked telopeptide of type I collagen and osteocalcin in response to exercise in well-trained men and women. Scand J Med Sci Sports 4:186–190

    Article  Google Scholar 

  26. Virtanen P, Viitasalo JT, Vouri J, Väänänen K, Takala TES (1993) Effect of concentric exercise on serum muscle and collagen markers. J Appl Physiol 3:1272–1277

    Google Scholar 

  27. Thorsen K, Kristoffersson A, Lorentzon R (1996) The effects of brisk walking on markers of bone and calcium metabolism in postmenopausal women. Calcif Tissue Int 58:221–225

    PubMed  CAS  Google Scholar 

  28. Fellman N (1992) Hormonal and plasma volume alterations following endurance exercise. A brief review. Sports Med 13:37–49

    Article  Google Scholar 

  29. van Beaumont W (1972) Evaluation of hemoconcentration from hematocrit measurements. J Appl Physiol 32:712–713

    PubMed  Google Scholar 

  30. Cann CE, Martin MC, Genant HK, Jaffe R (1984) Decreased spinal mineral content in amenorrheic women. JAMA 251: 626–629

    Article  PubMed  CAS  Google Scholar 

  31. Drinkwater BL, Nilson K, Chesnut CH III, Bremner WJ, Shainholtz S, Southworth MB (1984) Bone mineral content of amenorrheic and eumenorrheic athletes. N Engl J Med 311: 277–281

    PubMed  CAS  Google Scholar 

  32. Price JS, Jackson B, Eastell R, Wilson AM, Russell RGG, Lanyon LE, Goodship AE (1995) The response of the skeleton to physical training: a biochemical study in horses. Bone 17: 221–227

    Article  PubMed  CAS  Google Scholar 

  33. Zaman G, Dallas SL, Lanyon LE (1992) Cultured embryonic bone shafts show osteogenic responses to mechanical loading. Calcif Tissue Int 51:132–136

    Article  PubMed  CAS  Google Scholar 

  34. Cheng MZ, Zaman G, Lanyon LE (1994) Estrogen enhances the stimulation of bone collagen synthesis by loading and exogenous prostacyclin, but not prostaglandin E2, in organ cultures of rat ulnae. J Bone Miner Res 9:805–816

    Article  PubMed  CAS  Google Scholar 

  35. Harter LV, Hruska KA, Duncan RL (1995) Human osteoblast-like cells respond to mechanical strain with increased bone matrix protein production independent of hormonal regulation. Endocrinology 136:528–535

    Article  PubMed  CAS  Google Scholar 

  36. Pead MJ, Skerry TM, Lanyon LE (1988) Direct transformation from quiecence to bone formation in the adult periosteum following a single brief period of bone loading. J Bone Miner Res 3:647–655

    Article  PubMed  CAS  Google Scholar 

  37. Raab-Mullen DM, Thiede MA, Petersen DN, Kimmel DB, Recker RR (1994) Mechanical loading stimulates rapid changes in periosteal gene expression. Calcif Tissue Int 55: 473–478

    Article  Google Scholar 

  38. Nishiyama S, Tomoeda S, Ohta T, Higuchi A, Matsuda I (1988) Differences in basal and postexercise osteocalcin levels in athletic and nonathletic humans. Calcif Tissue Int 43: 150–154

    Article  PubMed  CAS  Google Scholar 

  39. Roach HI (1994) Why does bone matrix contain noncollagenous proteins? The possible roles of osteocalcin, osteonectin and bone sialoprotein in bone mineralisation and resorption. Cell Biol Int 18:617–628

    Article  PubMed  CAS  Google Scholar 

  40. Lukert BP, Higgins JC, Stoskopf MM (1986) Serum osteocalcin is increased in patients with hyperthyroidism and decreased in patients receiving glucocorticoids. J Clin Endocrinol Metab 62:1056–1058

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Orthopaedics, Sports Medicine Unit, University Hospital of Northern Sweden, S-901 85, Umeå, Sweden

    K. Thorsen & R. Lorentzon

  2. Department of Clinical Chemistry, University Hospital of Northern Sweden, S-901 85, Umeå, Sweden

    A. Kristoffersson

  3. Department of Surgery, University Hospital of Northern Sweden, S-901 85, Umeå, Sweden

    J. Hultdin

Authors
  1. K. Thorsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Kristoffersson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Hultdin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Lorentzon
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thorsen, K., Kristoffersson, A., Hultdin, J. et al. Effects of moderate endurance exercise on calcium, parathyroid hormone, and markers of bone metabolism in young women. Calcif Tissue Int 60, 16–20 (1997). https://doi.org/10.1007/s002239900179

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002239900179

Key words

Search

Navigation