Abstract
A randomized, prospective, double-blind test was carried out to compare the effects of heated oyster shell-seaweed calcium (AAA Ca), calcium carbonate, and placebo in 58 elderly, hospitalized women with the mean age of 80 divided into three groups. Group A received 900 mg/day Ca as AAA Ca, Group B 900 mg/day Ca as CaCO3, and Group C placebo besides regular hospital diet containing approximately 600 mg Ca/day for 24 months. From the 25th to the 30th month, all groups were given AAA Ca. Lumbar spine and radial bone mineral density (BMD) were measured at 3-month intervals. Urinary Ca/Cr and serum alkaline phosphatase, intact and midportion serum parathyroid hormone (PTH), and calcitonin were also measured at intervals. From the 6th to the 24th month of the study, the ratio of lumbar spine BMD (L2–L4 by DPX, Lunar) to the basal pretest value was consistently and significantly higher in Group A than Group C but not higher in Group B than in Group C. PTH, measured 12 months after the beginning of the study, was lower in Group A than in Group C, but no significant difference was found between Groups B and C. At 3 months after the placebo was switched to AAA Ca in Group C, serum PTH was significantly decreased from the level during placebo supplement. Morning urine Ca/Cr decreased in Groups A after 18 months and in B after 12 months, but not in C. Serum alkaline phosphatase decreased in Group A significantly compared with Group C, but not in Group B. AAA Ca appears to be effective for increasing BMD in elderly subjects.
Similar content being viewed by others
References
Fujita T, Fukase M, Nakada M, Koishi M (1988) Intestinal absorption of oyster shell electrolysate. Bone Miner 4:321–327
Yoshimoto Y, Tsukamoto T, Fukase M, Imai Y, Fujii T, Nakai M, Fujimori A, Ohno K, Ikeda K, Yamada H, Nishikawa M, Yamamoto Y, Kitazawa R, Fujita T (1990) Bioavailability of oyster shell electrolysate. J Bone Miner Metab 8:87–90
Fujita T, Fukase M, Miyamoto H, Matsumoto T, Ohue T (1990) Increase of bone mineral density by calcium supplement with oyster shell electrolysate. Bone Miner 11:85–91
Fujita T (1993) Oyster shell electrolysate (AACa) with high biological availability. J Bone Miner Metab 11:S41–45
Fukuda S (1993) Effects of active amino acid calcium: its bioavailability on intestinal absorption, osteoporosis and removal of plutonium in animals. J Bone Miner Metab 11:S47–51
Lee YS, Noguchi T, Naito H (1983) Intestinal absorption of calcium in rats given diets containing casein or amino acid mixture: the role of casein phosphopeptides. Br J Nutr 49:67–76
Orimo H, Fujita T, Goto Y, Yoshikawa M (1967) Mechanism of hypercalcemic effect of I-valine in parathyroidectomized rats. Endocrinol Jpn 80:200–202
Polley JK, Nordin BEC, Bughurst PA, Walker CJ, Chatterton BE (1987) Effect of calcium supplementation on forearm bone mineral density in postmenopausal women. J Nutr 117:1929–1935
Dawson-Hughes B, Dallas GE, Krall GE (1990) A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med 323:878–883
Aloia JF, Vaswani A, Yeh JK, Ross PL, Flaster E, Dilnanian FA (1994) Calcium replacement with and without hormone replacement therapy to prevent postmenopausal bone loss. Ann Intern Med 120:97–103
Smith EL, Gilligan C, Smith PE, Sempos CT (1989) Calcium supplementation and bone loss in middle-aged women. Am J Clin Nutr 50:833–842
Elders P, Netelenbos J, Lips P, van Ginkel F, Khoe E, Leeuwenkamp O, Hackeng W, van der Stelt P (1991) Calcium supplementation reduces vertebral bone loss in perimenopausal women: a controlled trial in 248 women between 46 and 58 years of age. J Clin Endocrinol Metab 73:533–540
Prince R, Smith M, Dick I, Price R, Webb P, Henderson N, Harris M (1991) Prevention of postmenopausal osteoporosis: a comparative study of exercise, calcium supplementation and hormone-replacement therapy. N Engl J Med 325:1189–1195
Riis B, Thomsen K, Cristiansen C (1987) Does calcium supplementation prevent postmenopausal bone loss? A doubleblind, controlled clinical study. N Engl J Med 316:173–177
Nilas L, Christiansen C, Rodbro P (1984) Calcium supplementation and postmenopausal bone loss. Br Med J 289:1103–1106
Dawson-Hughes B (1991) Calcium supplementation and bone loss: a review of controlled clinical trials. Am J Clin Nutr 54:274S-280S
Cumming RG (1990) Calcium intake and bone mass: a quantitative review of the evidence. Calcif Tissue Int 47:194–201
Elders PJM, Lips P, Netelenbos JC, van Ginkel FC, Khoe E, van der Vijgh WJF, van der Stelt PF (1994) Long-term effect of calcium supplementation on bone loss in perimenopausal women. J Bone Miner Res 9:963–970
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fujita, T., Ohue, T., Fujii, Y. et al. Heated oyster shell-seaweed calcium (AAA Ca) on osteoporosis. Calcif Tissue Int 58, 226–230 (1996). https://doi.org/10.1007/BF02508640
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02508640