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Bone Turnover Markers in Children: From Laboratory Challenges to Clinical Interpretation

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Abstract

Bone turnover markers (BTMs) have been developed many years ago to study, in combination with imaging techniques, bone remodeling in adults. In children and adolescents, bone metabolism differs from adults since it implies both growth and bone remodeling, suggesting an age- and gender-dependent BTM concentration. Therefore, specific studies have evaluated BTMs in not only physiological but also pathological conditions. However, in pediatrics, the use of BTMs in clinical practice is still limited due to these many children-related specificities. This review will discuss about physiological levels of BTMs as well as their modifications under pathological conditions in children and adolescents. A focus is also given on analytical and clinical challenges that restrain BTM usefulness in pediatrics.

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  1. Clinical Chemistry Department, CHU de Liège, Liège, Belgium

    Aurélie Ladang & Etienne Cavalier

  2. Shriners Hospital for Children, McGill University, Montreal, Canada

    Frank Rauch

  3. Centre & Department of Biochemistry, Ste-Justine University Hospital Research, Université de Montréal, Montreal, Canada

    Edgard Delvin

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Aurélie Ladang and Edgard Delvin declare no conflict of interest. Frank Rauch declare consulting or speaker fees for Novartic Inc, Ultragenyx Inc, and Sanofi Inc. Etienne Cavalier is consultant for IDS, DiaSorin, Fujirebio, Nittobo, bioMérieux, and Werfen.

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Ladang, A., Rauch, F., Delvin, E. et al. Bone Turnover Markers in Children: From Laboratory Challenges to Clinical Interpretation. Calcif Tissue Int 112, 218–232 (2023). https://doi.org/10.1007/s00223-022-00964-2

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