Abstract
Affective touch plays an important role in human social bonding, affiliative behavior, and in general emotional well-being. A system of unmyelinated low-threshold mechanosensitive C-type afferents innervating hairy skin (C-tactile or CT system) is postulated to provide the neurophysiological background of affective touch perception. C-tactile afferents respond optimally to soft and slow strokes, and this response correlates positively with pleasure ratings of tactile stimuli. As gentle touch is consistently associated with oxytocin release further promoting prosocial behavior, it has been suggested that this effect is mediated by the response of C-tactile afferents. This study assesses a possible link between CT-optimal touch, its subjective pleasantness, EEG indices of cortical arousal, and peripheral oxytocin response. EEG was recorded in 28 healthy volunteers during resting state and tactile stimulation[gentle slow brush strokes on forearm (CT-targeted touch) and palm (non-CT-targeted touch)]. Saliva samples were collected before and after the touch stimulation. Oxytocin concentration increase was significantly associated with greater subjective ratings of CT-targeted touch but not of non-CT-targeted touch, and with lower peak alpha frequency values indicating decreased cortical arousal. The findings suggest that CT-targeted stimulation triggers oxytocin release but only when the touch is perceived at an individual level as having clearly positive affective salience. This corresponds to previous studies reporting that oxytocin response to touch can be related to different personality factors, and bears important implications for planning touch-based interventions in social and medical care.
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The study was supported by RFBR, project No 18-00-01511-komfi (18-00-01511).
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GP: conceptualization, data curation, formal analysis, funding acquisition, investigation, methodology, project administration, resources, supervision, visualization, original draft, review and editing. EP: conceptualization, data curation, methodology, supervision, validation, original draft, review and editing. SS formal analysis, investigation, validation, visualization. IS: formal analysis, investigation, software, project administration, AV: conceptualization, funding acquisition, investigation, methodology, supervision, visualization, review and editing.
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Communicated by Francesco Lacquaniti.
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Portnova, G.V., Proskurnina, E.V., Sokolova, S.V. et al. Perceived pleasantness of gentle touch in healthy individuals is related to salivary oxytocin response and EEG markers of arousal. Exp Brain Res 238, 2257–2268 (2020). https://doi.org/10.1007/s00221-020-05891-y
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DOI: https://doi.org/10.1007/s00221-020-05891-y