Abstract
The increasing demand of space flights requires a profound knowledge of the chronologic reactions of the human body to extreme conditions. Prior studies already have shown the adverse effects of long-term isolation on psycho-physiological well-being. The chronology of the effects and whether short-term isolation periods already lead to similar effects has not been investigated. Therefore, the aim of the current study was to investigate the effects of short-term isolation (30 days) on mood, cognition, cortisol, neurotrophic factors, and brain activity. 16 participants were isolated in the Human Exploration Research Analog at NASA for 30 days. 17 non-isolated control participants were tested simultaneously. On mission days − 5, 7, 14, 28, and + 5, multiple tests including the Positive and Negative Affect Schedule-X and cognitive tests were conducted, and a 5-min resting electroencephalography was recorded. A fasted morning blood drawing was also done. Increased stress was observed via augmented cortisol levels during the isolation period. Activity within the parietal cortex was reduced over time, probably representing a neural adaptation to less external stimuli. Cognitive performance was not affected, but rather enhanced in both groups. No further significant changes in neurotrophic factors BDNF/IGF-1 and mood could be detected. These results suggest that 30 days of isolation do not have a significant impact on brain activity, neurotrophic factors, cognition, or mood, even though stress levels were significantly increased during isolation. Further studies need to address the question as to what extent increased levels of stress do not affect mental functions during isolation periods.
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Abbreviations
- HPA:
-
Hypothalamic–pituitary–adrenal axis
- BDNF:
-
Brain-derived neurotrophic factor
- IGF-1:
-
Insulin-like growth factor 1
- LORETA:
-
Low-resolution brain electromagnetic tomography
- HERA:
-
Human exploration research analog
- IG:
-
Isolation group
- CG:
-
Control group
- MD:
-
Mission day
- PANAS-X:
-
Positive and negative affect schedule-X
- GPA:
-
General positive affect
- GNA:
-
General negative affect
- EEG:
-
Electroencephalography
- ACTH:
-
Adrenocorticotropic hormone
- PFC:
-
Prefrontal cortex
References
Abeln V, MacDonald-Nethercott E, Piacentini MF, Meeusen R, Kleinert J, Strueder HK, Schneider S (2015) Exercise in isolation—a countermeasure for electrocortical, mental and cognitive impairments. PLoS One. https://doi.org/10.1371/journalpone0126356
Al-Shargie F, Tang TB, Kiguchi M (2017) Assessment of mental stress effects on prefrontal cortical activities using canonical correlation analysis: an fNIRS-EEG study. Biomed Opt Express 8(5):2583–2598
Andersen RA (1997) Multimodal integration for the representation of space in the posterior parietal cortex. Philos Trans R Soc Lond B Biol Sci 352(1360):1421–1428. https://doi.org/10.1098/rstb.1997.0128
Anderson MF, Åberg MA, Nilsson M, Eriksson PS (2002) Insulin-like growth factor-I and neurogenesis in the adult mammalian brain. Brain Res Dev Brain Res 134(1–2):115–122. https://doi.org/10.1016/S0165-3806(02)00277-8
Bachman KRO, Otto C, Leveton L (2012) Countermeasures to mitigate the negative impact of sensory deprivation and social isolation in long-duration space flight. NASA/TM-2012-217365, NASA
Balestrini S, Francione S, Mai R, Castana L, Casaceli G, Marino D, Provinciali L, Cardinale F, Tassi L (2015) Multimodal responses induced by cortical stimulation of the parietal lobe: a stereo-electroencephalography study. Brain 138(9):2596–2607. https://doi.org/10.1093/brain/awv187
Barrientos RM, Sprunger DB, Campeau S, Higgins EA, Watkins LR, Rudy JW, Maier SF (2003) Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist. Neuroscience 121(4):847–853. https://doi.org/10.1016/S0306-4522(03)00564-5
Basner M, Dinges DF, Mollicone D, Ecker A, Jones CW, Hyder EC, Di Antonio A, Savelev I, Kann K, Goel N, Morukov BV, Sutton JP (2013) Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing. Proc Natl Acad Sci USA 110(7):2635–2640. https://doi.org/10.1073/pnas.1212646110
Basner M, Dinges DF, Mollicone DJ, Savelev I, Ecker AJ, Di Antonio A, Jones CW, Hyder EC, Kan K, Morukov BV, Sutton JP (2014) Psychological and behavioral changes during confinement in a 520-day simulated interplanetary mission to mars. PLoS One. https://doi.org/10.1371/journalpone0093298
Baumeister RF, DeWall CN, Ciarocco NJ, Twenge JM (2005) Social exclusion impairs self-regulation. J Pers Soc Psychol 88(4):589
Bechtel RB, Berning A (1991) The third-quarter phenomenon: do people experience discomfort after stress has passed? In: Harrison AA, Clearwater YA, McKay CP (eds) From Antarctica to outer space. Springer, New York, NY, pp 261–265
Brodt S, Pöhlchen D, Flanagin VL, Glasauer S, Gais S, Schönauer M (2016) Rapid and independent memory formation in the parietal cortex. Proc Natl Acad Sci USA 113(46):13251–13256. https://doi.org/10.1073/pnas.1605719113
Cacioppo JT, Cacioppo S (2014) Social relationships and health: the toxic effects of perceived social isolation. Soc Pers Psychol Compass 8(2):58–72. https://doi.org/10.1111/spc3.12087
Cacioppo JT, Ernst JM, Burleson MH, McClintock MK, Malarkey WB, Hawkley LC, Kowlewski RB, Paulsen A, Hobson JA, Hugdahl K, Spiegel D, Berntson GG (2000) Lonely traits and concomitant physiological processes: the MacArthur social neuroscience studies. Int J Psychophysiol 35(2–3):143–154. https://doi.org/10.1016/S0167-8760(99)00049-5
Cacioppo JT, Cacioppo S, Capitanio JP, Cole SW (2015) The neuroendocrinology of social isolation. Annu Rev Psychol 66:733–767. https://doi.org/10.1146/annurev-psych-010814-015240
Campbell WK, Krusemark EA, Dyckman KA, Brunell AB, McDowell JE, Twenge JM, Clementz BA (2006) A magnetoencephalography investigation of neural correlates for social exclusion and self-control. Soc Neurosci 1(2):124–134. https://doi.org/10.1080/17470910601035160
Chouker A, Smith L, Christ F, Larina I, Nichiporuk I, Baranov V, Bobrovnik E, Pastushkova L, Messmer K, Peter K, Thiel M (2002) Effects of confinement (110 and 240 days) on neuroendocrine stress response and changes of immune cells in men. J Appl Physiol 92(4):1619–1627. https://doi.org/10.1152/japplphysiol.00732.2001
Cromwell RL, Neigut JS (2014) Human Research program human exploration research analog (HERA). Experiment Information Package, Flight analog projects
Duman RS, Monteggia LM (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59(12):1116–1127. https://doi.org/10.1016/j.biopsych.2006.02.013
Epel ES (2009) Psychological and metabolic stress: a recipe for accelerated cellular aging. Hormones (Athens) 8(1):7–22
Etkin A, Egner T, Kalisch R (2011) Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 15(2):85–93. https://doi.org/10.1016/j.tics.2010.11.004
Friedler B, Crapser J, McCullough L (2015) One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition. Acta Neuropathol 129(4):493–509. https://doi.org/10.1007/s00401-014-1377-9
Gabriel G, van Baarsen B, Ferlazzo F, Kanas N, Weiss K, Schneider S, Whiteley I (2012) Future perspectives on space psychology: recommendations on psychosocial and neurobehavioural aspects of human spaceflight. Acta Astronaut 81(2):587–599. https://doi.org/10.1016/j.actaastro.2012.08.013
Golden J, Conroy RM, Bruce I, Denihan A, Greene E, Kirby M, Lawlor BA (2009) Loneliness, social support networks, mood and wellbeing in community-dwelling elderly. Int J Geriatr Psychiatry 24(7):694–700. https://doi.org/10.1002/gps.2181
Golkar A, Lonsdorf TB, Olsson A, Lindstrom KM, Berrebi J, Fransson P, Schalling M, Ingvarm M, Öhman A (2012) Distinct contributions of the dorsolateral prefrontal and orbitofrontal cortex during emotion regulation. PLoS One 7(11):e48107. https://doi.org/10.1371/journal.pone.0048107
Gong WG, Wang YJ, Zhou H, Li XL, Bai F, Ren QG, Zhang ZJ (2017) Citalopram ameliorates synaptic plasticity deficits in different cognition-associated brain regions induced by social isolation in middle-aged rats. Mol Neurobiol 54(3):1927–1938
Huang HJ, Liang KC, Ke HC, Chang YY, Hsieh-Li HM (2011) Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice. Brain Res 1371:150–160. https://doi.org/10.1016/j.brainres.2010.11.043
Jasper HH (1958) The ten-twenty electrode system of the International Federation. Electroencephalogr Clin Neurophysiol 10:370–375
Jacubowski A, Abeln V, Vogt T, Yi B, Choukèr A, Fomina E, Strüder HK, Schneider S (2015) The impact of long-term confinement and exercise on central and peripheral stress markers. Physiol Behav 152:106–111. https://doi.org/10.1016/jphysbeh201509017
Kern S, Oakes TR, Stone CK, McAuliff EM, Kirschbaum C, Davidson RJ (2008) Glucose metabolic changes in the prefrontal cortex are associated with HPA axis response to a psychosocial stressor. Psychoneuroendocrinology 33(4):517–529. https://doi.org/10.1016/j.psyneuen.2008.01.010
Kringelbach ML, Berridge KC (2010) The neuroscience of happiness and pleasure. Soc Res (New York) 77(2):659
Levitt HCCH (1971) Transformed up-down methods in psychoacoustics. J Acoust Soc Am 49(2B):467–477
Licinio J, Wong ML (2002) Brain-derived neurotrophic factor (BDNF) in stress and affective disorders. Mol Psychiatry 7:519. https://doi.org/10.1038/sj.mp.4001211
Liston C, McEwen BS, Casey BJ (2009) Psychosocial stress reversibly disrupts prefrontal processing and attentional control. Proc Natl Acad Sci USA 106(3):912–917. https://doi.org/10.1073/pnas.0807041106
McEwen BS (2004) Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann N Y Acad Sci 1032(1):1–7. https://doi.org/10.1196/annals.1314.001
O’Keefe LM, Doran SJ, Mwilambwe-Tshilobo L, Conti LH, Venna VR, McCullough LD (2014) Social isolation after stroke leads to depressive-like behavior and decreased BDNF levels in mice. Behav Brain Res 260:162–170. https://doi.org/10.1016/j.bbr.2013.10.047
Palinkas LA (2007) Psychosocial issues in long-term space flight: overview. Grav Sp Res 14(2):14
Palinkas LA, Houseal M (2000) Stages of change in mood and behavior during a winter in Antarctica. Environ Behav 32(1):128–141. https://doi.org/10.1177/00139160021972469
Pascual-Marqui RD, Michel CM, Lehmann D (1994) Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. Int J Psychophysiol 18(1):49–65. https://doi.org/10.1016/0167-8760(84)90014-X
Prokopova B, Hlavacova N, Vlcek M, Penesova A, Grunnerova L, Garafova A, Turcani P, Kollar B, Jezova D (2017) Early cognitive impairment along with decreased stress-induced BDNF in male and female patients with newly diagnosed multiple sclerosis. J Neuroimmunol 302:34–40. https://doi.org/10.1016/j.jneuroim.2016.11.007
Reed HL, Reedy KR, Palinkas LA, Van Do N, Finney NS, Case HS, Thomas J (2001) Impairment in cognitive and exercise performance during prolonged antarctic residence: effect of thyroxine supplementation in the polar triiodothyronine syndrome. J Clin Endocrinol Metab 86(1):110–116. https://doi.org/10.1210/jcem.86.1.7092
Saatman KE, Contreras PC, Smith DH, Raghupathi R, McDermott KL, Fernandez SC, Sanderson KL, Voddi M, McIntosh TK (1997) Insulin-like growth factor-1 (IGF-1) improves both neurological motor and cognitive outcome following experimental brain injury. Exp Neurol 147(2):418–427. https://doi.org/10.1006/exnr.1997.6629
Sauer J, Hockey GRJ, Wastell DG (1999) Performance evaluation in analogue space environments: adaptation during an 8-month Antarctic wintering-over expedition. Aviat Space Environ Med 70:230–235
Sävendahl L (2009) The effect of acute and chronic stress on growth. Sci Signal 5(247):pt9. https://doi.org/10.1126/scisignal2003484
Schneider S, Brümmer V, Carnahan H, Kleinert J, Piacentini MF, Meeusen R, Strüder HK (2010) Exercise as a countermeasure to psycho-physiological deconditioning during long-term confinement. Behav Brain Res 211(2):208–214. https://doi.org/10.1016/jbbr201003034
Schneider S, Abeln V, Popova J, Fomina E, Jacubowski A, Meeusen R, Strüder HK (2013) The influence of exercise on prefrontal cortex activity and cognitive performance during a simulated space flight to Mars (MARS500). Behav Brain Res 236:1–7. https://doi.org/10.1016/jbbr201208022
Sestieri C, Shulman GL, Corbetta M (2017) The contribution of the human posterior parietal cortex to episodic memory. Nat Rev Neurosci 18(3):183. https://doi.org/10.1038/nrn.2017.6
Strangman GE, Sipes W, Beven G (2014) Human cognitive performance in spaceflight and analogue environments. Aviat Space Environ Med 85(10):1033–1048. https://doi.org/10.3357/ASEM.3961.2014
Sungkarat S, Boripuntakul S, Kumfu S, Lord SR, Chattipakorn N (2018) Tai Chi improves cognition and plasma BDNF in older adults with mild cognitive impairment: a randomized controlled trial. Neurorehab Neural Repair 32(2):142–149. https://doi.org/10.1177/1545968317753682
Swanson HL, Sachse-Lee C (2001) Mathematical problem solving and working memory in children with learning disabilities: both executive and phonological processes are important. J Exp Child Psychol 79(3):294–321
Tilvis RS, Kähönen-Väre MH, Jolkkonen J, Valvanne J, Pitkala KH, Strandberg TE (2004) Predictors of cognitive decline and mortality of aged people over a 10-year period. J Gerontol A Biol Sci Med Sci 59(3):268–274. https://doi.org/10.1093/gerona/59.3.M268
Tsigos C, Chrousos GP (2002) Hypothalamic–pituitary–adrenal axis, neuroendocrine factors and stress. J Psychosom Res 53(4):865–871. https://doi.org/10.1016/S0022-3999(02)00429-4
Tugade MM, Fredrickson BL (2004) Resilient individuals use positive emotions to bounce back from negative emotional experiences. J Pers Soc Psychol 86(2):320
Watson D, Clark A (1999) The PANAS-X: manual for the positive and negative affect schedule—expanded form. The University of Iowa, Ames
Van Baarsen B, Ferlazzo F, Ferravante, D, Di Nocera F, Jørgensen J, Smit J, van Duijn M, Giannini AM, Kuipers A, van der Pligt J (2009) Digging into space psychology and isolation: the Mars500 lodgead study primary results of the Mars105 pilot study. In: International astronautical congress
Wilson RS, Krueger KR, Arnold SE, Schneider JA, Kelly JF, Barnes LL, Tang Y, Bennett DA (2007) Loneliness and risk of Alzheimer disease. Arch Gen Psychiatry 64(2):234–240
Acknowledgements
This study was supported by a grant from the German Ministry of Economic Affairs and Energy (BMWi) as handled by German Space Agency (DLR), grant No. 50WB1516 to Vera Abeln. The authors would like to thank all participants and all HERA team members with a particular gratitude to Tiffany Swarmer.
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Weber, J., Javelle, F., Klein, T. et al. Neurophysiological, neuropsychological, and cognitive effects of 30 days of isolation. Exp Brain Res 237, 1563–1573 (2019). https://doi.org/10.1007/s00221-019-05531-0
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DOI: https://doi.org/10.1007/s00221-019-05531-0