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Functional anatomy of 5-HT2A receptors in the amygdala and hippocampal complex: relevance to memory functions

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Abstract

The amygdaloid complex and hippocampal region contribute to emotional activities, learning, and memory. Mounting evidence suggests a primary role for serotonin (5-HT) in the physiological basis of memory and its pathogenesis by modulating directly the activity of these two areas and their cross-talk. Indeed, both the amygdala and the hippocampus receive remarkably dense serotoninergic inputs from the dorsal and median raphe nuclei. Anatomical, behavioral and electrophysiological evidence indicates the 5-HT2A receptor as one of the principal postsynaptic targets mediating 5-HT effects. In fact, the 5-HT2A receptor is the most abundant 5-HT receptor expressed in these brain structures and is expressed on both amygdalar and hippocampal pyramidal glutamatergic neurons as well as on γ-aminobutyric acid (GABA)-containing interneurons. 5-HT2A receptors on GABAergic interneurons stimulate GABA release, and thereby have an important role in regulating network activity and neural oscillations in the amygdala and hippocampal region. This review will focus on the distribution and physiological functions of the 5-HT2A receptor in the amygdala and hippocampal region. Taken together the results discussed here suggest that 5-HT2A receptor may be a potential therapeutic target for those disorders related to hippocampal and amygdala dysfunction.

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Authors and Affiliations

  1. Department of Veterinary Medical Science, University of Bologna, 40064, Ozzano dell’Emilia, Bologna, Italy

    Cristiano Bombardi

  2. Neuroscience Division, School of Biosciences, Cardiff University, Life Sciences Building, Museum Avenue, Cardiff, CF10 3AX, UK

    Giuseppe Di Giovanni

  3. Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Tal-Qroqq, Malta

    Giuseppe Di Giovanni

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  1. Cristiano Bombardi
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Correspondence to Cristiano Bombardi or Giuseppe Di Giovanni.

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Bombardi, C., Di Giovanni, G. Functional anatomy of 5-HT2A receptors in the amygdala and hippocampal complex: relevance to memory functions. Exp Brain Res 230, 427–439 (2013). https://doi.org/10.1007/s00221-013-3512-6

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