Abstract
Exposure to novel environments is known to induce c-fos expression in the cingulate cortex and dorsomedial striatum. This study examined the effects of 1, 3, and 7 days of exposure to sequential exposure to three novel environments. It was hypothesized that the ability of novel environment shuttling (NES) would induce c-fos expression as indicated by cells displaying FOS-like immunoreactivity (FLI) in the striatum and cingulate cortex which would decrease with repeated exposure. NES elicited FLI in both the cingulate cortex and striatum when compared to home-cage controls and this effect was attenuated with repeated exposure. Behavioral measures of activity decreased with repeated exposure suggesting that the decrease in FLI may be due to either a reduction in motor activity or increasing familiarity with the environments.
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Struthers, W.M., DuPriest, A. & Runyan, J. Habituation reduces novelty-induced FOS expression in the striatum and cingulate cortex. Exp Brain Res 167, 136–140 (2005). https://doi.org/10.1007/s00221-005-0061-7
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DOI: https://doi.org/10.1007/s00221-005-0061-7