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Formation of porous α-CD ethanol dihydrate by crystal transformation method

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Abstract

The crystal transformation method using ethanol as a dehydration medium is a new method which can create a porous crystal. In this study α-cyclodextrin (α-CD) hexahydrate was transformed by this method and porous ethanol dihydrate crystal was obtained. The pore volume measured was 0.25 mL/g and the median pore diameter was 0.11 μm. Dissolution rate of this crystal was several times higher than that of (α-CD) hexahydrate or anhydrate obtained by drying.

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Abbreviations

α-CD:

α-Cyclodextrin

α-CD·6H2O:

α-Cyclodextrin hexahydrate

CDs:

Cyclodextrines

RH:

Relative humidity

XRD:

X-ray powder diffraction

SEM:

Scanning electron microscopy

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Authors and Affiliations

  1. Department of Biotechnology, Tottori University, Koyama Minami 4-1, Tottori, 680-8552, Japan

    Tetsuya Ohashi, Nicolas Verhoeven, Daisuke Okuda, Takeshi Furuta & Hidefumi Yoshii

  2. Production Technology Development, Hayashibara Co., Ltd, 7-7 Amase minamimachi, Okayama, 700-0834, Japan

    Tetsuya Ohashi

Authors
  1. Tetsuya Ohashi
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  2. Nicolas Verhoeven
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  3. Daisuke Okuda
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  4. Takeshi Furuta
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  5. Hidefumi Yoshii
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Correspondence to Hidefumi Yoshii.

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Ohashi, T., Verhoeven, N., Okuda, D. et al. Formation of porous α-CD ethanol dihydrate by crystal transformation method. Eur Food Res Technol 230, 195–199 (2009). https://doi.org/10.1007/s00217-009-1150-9

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  • DOI: https://doi.org/10.1007/s00217-009-1150-9

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