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Determination of bisphenol A diglycidyl ether (BADGE) and its derivatives in food: identification and quantification by internal standard

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Abstract

Bisphenol A diglycidyl ether (BADGE) and its reaction products with water and hydrochloric acid have recently been subject to new regulations concerning their migration from food packaging into foodstuff. A method for the simultaneous identification and quantification of these substances and their precursor bisphenol A in food is described introducing bisphenol A di-(3-hydroxypropyl)ether as an internal standard.

Analysis was carried out using RP-HPLC gradient elution with fluorescence detection. Additional information in the case of suspect samples was obtained using RP-HPLC with mass selective detection. The described method is validated for the analysis of foodstuffs as well as fatty food simulants. The limits of detection were between 10 and 30 µg/kg of food; recovery experiments gave identical behaviour for all analytes and the internal standard. The enforcement of the specific migration limit set by regulatory standards of the European Union for BADGE and its hydrolysis and hydrochlorination products is possible for producers as well as food quality surveillance institutions.

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Acknowledgements

The investigations were promoted by the Federal German Ministry of Defence (InSan I 1098-V-7501). Analytical assistance was granted by institutions of the University of Hamburg. NMR analyses were carried out by the department of organic chemistry, elementary analysis by the central element analysis.

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Authors and Affiliations

  1. Central Institute of the Medical Services German Armed Forces Kiel-Kronshagen, Kopperpahler Allee 120, 24119 , Kronshagen, Germany

    H. Petersen

  2. Institute of Biochemistry and Food Chemistry, University of Hamburg, Grindelallee 117, 20146 , Hamburg, Germany

    H. Petersen, A. Schaefer, C. A. Buckow & H. Steinhart

  3. Institute of Food Chemistry, Dresden University of Technology, Bergstrasse 66, 01062 , Dresden, Germany

    T. J. Simat

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  1. H. Petersen
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  2. A. Schaefer
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  3. C. A. Buckow
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  4. T. J. Simat
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  5. H. Steinhart
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Correspondence to H. Petersen.

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Petersen, H., Schaefer, A., Buckow, C.A. et al. Determination of bisphenol A diglycidyl ether (BADGE) and its derivatives in food: identification and quantification by internal standard. Eur Food Res Technol 216, 355–364 (2003). https://doi.org/10.1007/s00217-002-0648-1

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  • DOI: https://doi.org/10.1007/s00217-002-0648-1

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