Abstract.
The direct quantification of cocaine in urine has been achieved using time-of-flight secondary-ion mass spectrometry (TOF-SIMS). The dynamic range of the TOF-SIMS is four orders of magnitude using one internal standard concentration. The limit of detection (LOD) and limit of quantification (LOQ) have been determined to be 3 ng/mL and 10 ng/mL, respectively, for MeOH standards; the LOD and LOQ have been 33 ng/mL and 100 ng/mL, respectively, in urine samples. Coefficients of variation have ranged from 0.7 to 2.7 for the MeOH standards and 2.5 to 8.0 for the urine samples. The use of TOF-SIMS to simultaneously detect multiple drugs in urine is also demonstrated. The advantages and disadvantages of directly quantifying drugs in urine are discussed. Practical considerations regarding the use of matrix-assisted laser desorption/ionization mass spectrometry for multi-component analysis are also presented.
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Received: 7 February 1995/Accepted: 27 February 1995
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ID="*" Present address: Pacific Northwest Laboratory, Chemical Methods and Separations Group, Chemical Sciences Department, Battelle Blvd., P.O. Box 999, Richland, WA 99357, USA
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ID="**" Present address: Department of Chemistry, Vanderbilt University, Box 1822 Station B, Nashville TN 37235, USA
Correspondence to: D.M. Hercules
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Muddiman, D., Gusev, A., Martin, L. et al. Direct quantification of cocaine in urine by time-of-flight mass spectrometry. Fresenius J Anal Chem 354, 103–110 (1996). https://doi.org/10.1007/s002169600017
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DOI: https://doi.org/10.1007/s002169600017