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Gold nanoparticles assisted laser desorption/ionization mass spectrometry and applications: from simple molecules to intact cells

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Abstract

Gold nanoparticles (AuNPs) assisted laser desorption/ionization mass spectrometry (GALDI-MS) provided new horizons and offered many functions for various applications. This review summarized AuNPs applications for analytical, biotechnology and proteomics. AuNPs efficiently absorbed the laser radiation and transferred the energy to the analyte for the desorption/ionization process. The unique features of AuNPs such as large surface area and high absorption coefficient lead not only to high resolution, low interference and low limit of detection, but also offered selective detection for certain species. AuNPs provided an excellent surface for the analysis of several species such as small molecules, biomarkers, proteins and cells (pathogenic bacteria or cancer cells). AuNPs played many roles such as surface for LDI-MS, probe and stationary phase for separation or preconcentration. AuNPs modified various surface chemistry was applied for a wide range of different wavelength. AuNPs severed as a source of Au+ ions that were suitable for analyte cationisation. Characterization of Au nanoclusters (AuNCs) by mass spectrometry, pros and cons were also highlighted.

Schematic representation of the analysis by Gold Nanoparticles Assisted Laser Desorption/Ionization Mass Spectrometry (GALDI-MS)

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Abbreviations

ATP:

Adenosine triphosphate

CHCA:

α-cyano-4-hydroxycinnamic acid, alpha-cyano or alpha-matrix

FA:

2-amino-4,5-diphenylfuran-3-carboxylic acid, furoic acid

MA:

2-(2,3-dimethylphenyl)aminobenzoic acid, mefenamic acid

AuNCs:

Au nanoclusters

bio-SH:

Biothiols

Cys:

Cysteine

DIOS:

Desorption/ionization on porous silicon

DHB:

2,5-dihydroxybenzoic acid

ESI-MS:

Electrospray ionization mass spectrometry

F4-ICPMS:

Flow-Field-Flow Fractionation- inductively coupled plasma mass spectrometry

SPR:

Surface plasmon resonance

SERS:

Surface enhanced Raman spectroscopy

SALDI:

Surface-assisted laser desorption/ionization

SA:

5-dimethoxy-4-hydroxycinnamic acid, sinapinic acid

TAGs:

Triacylglycerols

VIS-MALDI:

Visible-wavelength matrix-assisted laser desorption/ionization

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Acknowledgments

H.F.Wu is particularly grateful to the Ministry of Science and Technology of Taiwan for her financial support. H.N. Abdelhamid thanks Assuit University and Ministry of Higher Education for the financial support.

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Authors and Affiliations

  1. Department of Chemistry, Assuit University, Assuit, 71515, Egypt

    Hani Nasser Abdelhamid

  2. Department of Chemistry and Center of Nanoscience and Nanotechnology, National Sun Yat-Sen University, Kaohsiung, 80424, ROC Taiwan

    Hui-Fen Wu

  3. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 807, ROC Taiwan

    Hui-Fen Wu

  4. Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung, 80424, ROC Taiwan

    Hui-Fen Wu

  5. Doctoral Degree Program in Marine Biotechnology, National Sun Yat-Sen University and Academia Sinica, Kaohsiung, 80424, ROC Taiwan

    Hui-Fen Wu

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  1. Hani Nasser Abdelhamid
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Abdelhamid, H.N., Wu, HF. Gold nanoparticles assisted laser desorption/ionization mass spectrometry and applications: from simple molecules to intact cells. Anal Bioanal Chem 408, 4485–4502 (2016). https://doi.org/10.1007/s00216-016-9374-6

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  • DOI: https://doi.org/10.1007/s00216-016-9374-6

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