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Recent advances of chromatography and mass spectrometry in lipidomics

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Abstract

Lipidomics, as a novel branch of metabolomics, which is aimed at comprehensive analysis of lipids and their biological roles with respect to health and diseases, has attracted increased attention from biological and analytical scientists. As a result of the complexity and diversity of lipids, accurate identification and efficient separation are required for lipidomics analysis. Mass spectrometry (MS) and chromatography have been extensively developed in the past few decades and hold a distinguished position in qualification and separation science. They are powerful and indispensable tools for lipidomics. Herein, we present the recent advancement of MS, chromatography, and their hyphenation technologies in lipidomics.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (NSFC), Grant Nos. 90717002, 20775090, and 20805001.

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Authors and Affiliations

  1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China

    Min Li, Zhigui Zhou, Honggang Nie, Yu Bai & Huwei Liu

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  1. Min Li
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  2. Zhigui Zhou
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  3. Honggang Nie
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  4. Yu Bai
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  5. Huwei Liu
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Correspondence to Huwei Liu.

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Li, M., Zhou, Z., Nie, H. et al. Recent advances of chromatography and mass spectrometry in lipidomics. Anal Bioanal Chem 399, 243–249 (2011). https://doi.org/10.1007/s00216-010-4327-y

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