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QSRR analysis of β-lactam antibiotics on a penicillin G targeted MIP stationary phase

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Abstract

The imprinting factors of the β-lactam antibiotics penicillin V, methicillin, nafcillin, oxacillin, cloxacillin, dicloxacillin, and piperacillin on a poly(methacrylic acid-co-trimethylolpropane trimethacrylate) molecularly imprinted stationary phase targeted for penicillin G were correlated with molecular descriptors obtained by molecular computation. One-parameter linear regression and multivariate data analysis by principal component analysis and partial least square regression indicated that descriptors associated with molecular topology, shape, size, and volume were highly correlated with the imprinting factor and influential on the derived models.

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Acknowledgments

This work was supported by the Swedish Foundation for Strategic Research through an Individual Grant for the Advancement of Research Leaders (INGVAR) to MK.

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Authors and Affiliations

  1. Biomedical Polymer Technology, Department of Experimental Medical Science, Biomedical Center, D11, Lund University, 221 84, Lund, Sweden

    Henrik Kempe & Maria Kempe

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  1. Henrik Kempe
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  2. Maria Kempe
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Correspondence to Maria Kempe.

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Kempe, H., Kempe, M. QSRR analysis of β-lactam antibiotics on a penicillin G targeted MIP stationary phase. Anal Bioanal Chem 398, 3087–3096 (2010). https://doi.org/10.1007/s00216-010-4254-y

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  • DOI: https://doi.org/10.1007/s00216-010-4254-y

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