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Development of tip-enhanced optical spectroscopy for biological applications: a review

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Abstract

Tip-enhanced optical spectroscopy is an approach that holds a good deal of promise for the nanoscale characterisation of matter. Tip-enhanced Raman spectroscopy (TERS) has been demonstrated on a variety of samples: inorganic, organic and biological. Imaging using TERS has been shown for carbon nanotubes due to their high scattering efficiency. There are a number of compelling motivations to consider alternative approaches for biological samples; most importantly, the potential for heat damage of biomolecules and long acquisition times. These issues may be addressed through the development of tip-enhanced coherent anti-Stokes Raman scattering microscopy.

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References

  1. McWilliams A (2008) Nanotechnology: a realistic market assessment. BCC Research, Wellesley (see http://www.bccresearch.com/report/NANO31C.html)

  2. Rothemund PWK (2006) Nature 440:297–302

    Article  CAS  Google Scholar 

  3. Abbe E (1873) Arch Mikrosc Anat 9:413–468

    Google Scholar 

  4. Betzig E, Finn PL, Weiner JS (1992) Appl Phys Lett 60:2484–2486

    Article  CAS  Google Scholar 

  5. Betzig E, Trautman JK (1992) Science 257:189–195

    Article  CAS  Google Scholar 

  6. Novotny L, Pohl DW (1995) NATO ASI Ser E184:21–33

    Google Scholar 

  7. Zenhausern F, O′Boyle MP, Wickramasinghe HK (1994) Appl Phys Lett 65:1623

    Article  CAS  Google Scholar 

  8. Zenhausern F, Martin Y, Wickramasinghe HK (1995) Science 269:1083–1085

    Article  CAS  Google Scholar 

  9. Hillenbrand R, Keilman F (2000) Phys Rev Lett 85:3029–3032

    Article  CAS  Google Scholar 

  10. Stockle RM, Suh YD, Deckert V, Zenobi R (2000) Chem Phys Lett 318:131–136

    Article  CAS  Google Scholar 

  11. Pettinger B, Ren B, Picardi G, Schuster R, Ertl G (2004) Phys Rev Lett 92:96101

    Article  Google Scholar 

  12. Pettinger B, Ren B, Picardi G, Schuster R, Ertl G (2005) J Raman Spectrosc 36:514–550

    Article  Google Scholar 

  13. Hayazawa N, Inouye Y, Sekkat Z, Kawata S (2001) Chem Phys Lett 335:369–374

    Article  CAS  Google Scholar 

  14. Downes A, Mouras R, Mari M, Elfick A (2009) J Raman Spectrosc (in press)

  15. Neacsu CC, Dreyer J, Behr N, Raschke NB (2006) Phys Rev B 73:193406

    Google Scholar 

  16. Domke KF, Zhang D, Pettinger B (2006) J Am Chem Soc 128:14721–14727

    Article  CAS  Google Scholar 

  17. Zhang W, Cui Yeo B-S, Schmid T, Hafner C, Zenobi R (2007) Nano Lett 7:1401–1405

    Article  CAS  Google Scholar 

  18. Hartschuh A, Pedrosa HN, Novotny L, Krauss TD (2003) Science 301:1354–1356

    Article  CAS  Google Scholar 

  19. Hayazawa N, Yano T, Watanabe H, Inouye Y, Kawata S (2003) Chem Phys Lett 376:174–180

    Article  CAS  Google Scholar 

  20. Anderson N, Hartschuh A, Novotny L (2007) Nano Lett 7:577–582

    Article  CAS  Google Scholar 

  21. Anderson N, Anger P, Hartschuh A, Novotny L (2006) Nano Lett 6:744–749

    Article  CAS  Google Scholar 

  22. Hartschuh A, Sanchez EJ, Xie XS, Novotny L (2003) Phys Rev Lett 90:95503

    Article  Google Scholar 

  23. Anderson N, Hartschuh A, Cronin S, Novotny L (2004) J Am Chem Soc 127:2533–2537

    Article  Google Scholar 

  24. Roy D, Wang J, Welland ME (2006) Faraday Discuss 132:215–226

    Article  CAS  Google Scholar 

  25. Feynman RP (1960) Eng Sci 23:22–26

    Google Scholar 

  26. Kodama T, Umezawa T, Watanabe S, Ohtani H (2008) J Microsc 229:240–246

    Article  CAS  Google Scholar 

  27. Gan Y (2007) Rev Sci Instrum 78:081101

    Article  Google Scholar 

  28. Ghenuche P, Cherukulappurath S, Taminiau T, Van Hulst NF, Quidan R (2008) Phys Rev Lett 101:116805

    Article  Google Scholar 

  29. Ren B, Picardi G, Pettinger B (2004) Rev Sci Instrum 75:837

    Article  CAS  Google Scholar 

  30. Eligal L, Culfaz F, McCaughan V, Cade NI, Richards D (2009) Rev Sci Instrum 80:0333701

    Google Scholar 

  31. Pan SH, Hudson EW, Davis JC (1998) Appl Phys Lett 73:2992

    Article  CAS  Google Scholar 

  32. Lin MF, Shung KW-K (1994) Phys Rev B 50:17744–17747

    Article  CAS  Google Scholar 

  33. Hillenbrand R, Keilmann F, Hanarp P, Sutherland DS, Aizpurua J (2003) Appl Phys Lett 83:368–370

    Google Scholar 

  34. de Wilde Y, Formanek F, Carminati R, Gralak B, Lemoine P-A, Joulain K, Mulet J-P, Chen Y, Greffet J-J (2006) Nature 444:740–743

    Article  Google Scholar 

  35. Brehm M, Taubner T, Hillenbrand R, Keilmann F (2006) Nano Lett 6:1307–13010

    Article  CAS  Google Scholar 

  36. Yeo B-S, Schmid T, Zhang W, Zenobi R (2007) Anal Bioanal Chem 387:2655–2662

    Article  CAS  Google Scholar 

  37. Taguchi A, Hayazawa N, Saito Y, Ishitobi H, Tarun A, Kawata S (2009) Opt Express 17:6509–6518

    Article  CAS  Google Scholar 

  38. Ikeda K, Fujimoto N, Uehara H, Uosaki K (2008) Chem Phys Lett 460:205–208

    Article  CAS  Google Scholar 

  39. Notingher I, Elfick A (2005) J Phys Chem B 109:15699–15706

    Article  CAS  Google Scholar 

  40. Pettinger B, Domke KF, Zhang D, Picardi G, Schuster R (2009) Surf Sci 603:1335–1341

    Article  CAS  Google Scholar 

  41. Downes A, Salter D, Elfick A (2006) J Phys Chem B 110:6692–6698

    Article  CAS  Google Scholar 

  42. Downes A, Salter D, Elfick A (2008) J Microsc Oxford 229:184–188

    Google Scholar 

  43. Domke KF, Zhang D, Pettinger B (2007) J Phys Chem C 111:8611–8616

    Article  CAS  Google Scholar 

  44. Karrai K, Grober RD (1995) Appl Phys Lett 66:1842–1844

    Article  CAS  Google Scholar 

  45. Rensen WHJ, van Hulst NF, Kammer SB (2000) Appl Phys Lett 77:1557–1559

    Article  CAS  Google Scholar 

  46. Albrecht TR, Grütter P, Horne D, Rugar D (1991) J Appl Phys 69:668–673

    Article  Google Scholar 

  47. Higgins MJ, Reiner C, Uchihashi T, Sader JE, McKendry R, Jarvis SP (2005) Nanotechnology 16:S85–S89

    Article  CAS  Google Scholar 

  48. Hembacher S, Giessibl FJ, Mannhart J (2004) Science 305:380–383

    Article  CAS  Google Scholar 

  49. Downes A, Welland ME (1998) Phys Rev Lett 81:1857–1860

    Article  CAS  Google Scholar 

  50. Downes A, Dumas P (2002) Appl Surf Sci 212–213:770–774

    Google Scholar 

  51. Downes A, Salter D, Elfick A (2006) Opt Express 14:11324–11329

    Article  Google Scholar 

  52. Mangum BD, Mu C, Gerton JM (2008) Opt Express 16:6183–6193

    Article  Google Scholar 

  53. Sánchez E, Novotny L, Xie XS (1999) Phys Rev Lett 82:4014–4017

    Article  Google Scholar 

  54. Hayazawa N, Furusawa K, Taguchi A, Kawata S, Hiroshi A (2009) Appl Phys Lett 94:193112

    Article  Google Scholar 

  55. Hartschuh A, Qian H, Meixner AJ, Anderson N, Novotny L (2006) Surf Interface Anal 38:1472–1480

    Article  CAS  Google Scholar 

  56. Rasmussen A, Deckert V (2006) J Raman Spectrosc 37:311–317

    Article  CAS  Google Scholar 

  57. Cialla D, Deckert-Gaudig T, Budich C, Laue M, Möller R, Naumann D, Deckert V, Popp J (2009) J Raman Spectrosc 40:240–243

    Article  CAS  Google Scholar 

  58. Yeo B-S, Madler S, Schmid T, Zhang W, Zenobi R (2008) J Phys Chem C 112:4867–4873

    Article  CAS  Google Scholar 

  59. Yeo B-S, Stadler J, Schmid T, Zenobi R, Zhang W (2009) Chem Phys Lett 472:1–13

    Article  CAS  Google Scholar 

  60. Neugebauer U, Rosch P, Schmitt M, Popp J, Julien C, Rasmussen A, Budich C, Deckert V (2006) ChemPhysChem 7:1428–1430

    Article  CAS  Google Scholar 

  61. Neugebauer U, Schmid U, Baumann K, Ziebuhr W, Kozitskaya S, Deckert V, Schmitt M, Popp J (2007) ChemPhysChem 8:124–137

    Article  CAS  Google Scholar 

  62. Ichimura T, Hayazawa N, Hashimoto M, Inouye Y, Kawata S (2004) Phys Rev Lett 92:220801

    Google Scholar 

  63. Geshev P, Klein S, Witting T, Dickmann K, Hietschold M (2004) Phys Rev B 70:75402

    Article  Google Scholar 

  64. Zhang W, Schmid T, Yeo B-S, Zenobi R (2008) J Phys Chem C 112:2104–2108

    Article  CAS  Google Scholar 

  65. Duncan MD, Reinjtes J, Manuccia TJ (1982) Opt Lett 7:350–352

    Article  CAS  Google Scholar 

  66. Zumbusch A, Holtom GR, Xie XS (1999) Phys Rev Lett 82:4142–4145

    Article  CAS  Google Scholar 

  67. Cheng JX, Jia KJ, Zheng G, Xie XS (2002) Biophys J 83:502–509

    Article  CAS  Google Scholar 

  68. Evans CL, Potma EO, Puoris′haag M, Côté D, Lin CP, Xie XS (2005) Proc Natl Acad Sci 102:16807

    Article  CAS  Google Scholar 

  69. Moger J, Johnston BD, Tyler CR (2008) Opt Express 16:3408–3419

    Article  CAS  Google Scholar 

  70. Schaller RD, Ziegelbauer J, Lee LF, Haber LH, Saykally RJ (2002) J Phys Chem B 106:8489–8492

    Article  CAS  Google Scholar 

  71. Downes A, Mouras R, Elfick A (2009) J Raman Spectrosc 40:757–762

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was funded by the Engineering and Physical Sciences Research Council, UK; APDE was supported with an Advanced Research Fellowship and Challenging Engineering Award (Grant No.s GR/S52155/01, GR/52148/01 and EP/E007864/1). ARD is an RCUK Academic Fellow in Biomedical Engineering.

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Authors and Affiliations

  1. Centre for Biomedical Engineering, The School of Engineering, The University of Edinburgh, Edinburgh, EH9 3JL, UK

    Alistair P. D. Elfick, Andrew R. Downes & Rabah Mouras

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  1. Alistair P. D. Elfick
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  2. Andrew R. Downes
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  3. Rabah Mouras
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Correspondence to Alistair P. D. Elfick.

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Elfick, A.P.D., Downes, A.R. & Mouras, R. Development of tip-enhanced optical spectroscopy for biological applications: a review. Anal Bioanal Chem 396, 45–52 (2010). https://doi.org/10.1007/s00216-009-3223-9

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