Abstract
In this paper, European food safety legislation is presented, and special attention is devoted to monitoring residues of veterinary drugs in foodstuffs of animal origin. After a short review of the state of the art of analytical methodology for antibiotic residue analysis, the paper focuses on validation of analytical methods, with Decision 657/2002/EC as reference document. Finally, the main issues of the quality control of the analytical data, i.e. analysis of reference materials and participation in proficiency tests, are briefly addressed.
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References
Viola C, DeVincent SJ (2006) Prev Vet Med 73:111–131
European Union press release IP/02/1720. Brussels, 21 November 2002
Kools SAE, Moltmann JF, Knacker T (2008) Regul Toxicol Pharmacol 50:59–65
Moulin G, Cavalié P, Pellanne I, Chevance A, Laval A, Millemann Y, Colin P, Chauvin C (2008) J Antimicrob Chemother 62:617–625
Animal Health Institute (2008) Sales of Disease-Fighting Animal Medicines Rise (press release November 14, 2008) Available online at http://www.ahi.org (accessed 3/3/2009)
Turnidge J (2004) J Antimicrob Chemother 53:26–27
Casewell M, Friis C, Marco E, McMullin P, Pillips I (2003) J Antimicrob Chemother 52:159–161
Regulation (EC) No 1831/2003 of the European Parliament and of the Council. Official Journal of the European Union L 268, 18.10.2003, p. 29
Wierup M (2001) Microb Drug Resistance 7:183–190
Muirhead S (2002) Feedstuffs 74:1–5
Phillips I (2007) Int J Antimicrob Agents 30:101–107
Grave K, Jensen VF, Odensvik K, Wierup M, Bangen M (2006) Prev Vet Med 75:123–132
Hammerum AM, Heuer OE, Lester CH, Agerso Y, Seyfarth AM, Emborg HD, Frimodt-Moller N, Monnet DL (2007) Int J Antimicrob Agents 30:466–468
Barceló D, Petrovic M (2007) Anal Bioanal Chem 387:1141–1142
Barceló D (2007) Trends Anal Chem 26:454–455
EU Council Recommendation of 15 November 2001 on the prudent use of antimicrobial agents in human medicine. Available on line at http://europa.eu/scadplus/leg/en/cha/c11569.htm (accessed 3/3/2009)
WHO Draft Recommendations on prudent use of antimicrobials in food-producing animals. Available on line at http://www.poultry-health.com/library/antimicrobials/whodra00.htm (accessed 3/3/2009)
International Federation for Animal Health (IFAH). http://www.ifaheurope.org (accessed 24.04.09)
Report for 2007 on the results of residue monitoring in food of animal origin in the Member Sates. Available on line at http://ec.europa.eu/food/food/chemicalsafety/residues/control_en.htm (accessed 3/3/2009)
Regulation (EC) No 178/2002 of the European Parliament and of the Council. Official Journal of the European Union L 031, 1.2.2002, p. 1
European Food Safety Authority. http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_home.htm (accessed 3/3/2009)
EU Directorate General for Health and Consumers. Rapid Alert System for Food and Feed. http://ec.europa.eu/food/food/rapidalert/index_en.htm (accessed 3/3/2009)
EU Directorate General for Health and Consumers. The Rapid Alert System for Food and Feed. Annual Report 2007. Available online at http://ec.europa.eu/food/food/rapidalert/report2007_en.pdf (accessed 3/3/2009)
Regulation (EC) No 882/2004 of the European Parliament and of the Council. Official Journal of the European Union L 165, 30.4.2004, p. 1
Council Directive 97/78/EC. Official Journal of the European Union L 24, 30.1.1998, p. 9
Regulation (EC) No 183/2005 of the European Parliament and of the Council. Official Journal of the European Union L 35, 8.2.2005, p. 1
Council Directive 90/167/EEC. Official Journal of the European Union L 92, 7.4.1990, p. 42
Council Regulation (EC) No 726/2004. Official Journal of the European Union L 136, 30.4.2004, p. 1
Directive 2001/82/EC of the European Parliament and of the Council. Official Journal of the European Union L 311, 28.11.2001, p. 1
European Medicines Agency (EMEA) http://www.emea.europa.eu/
Council Regulation (EEC) No 2377/90. Official Journal of the European Union L 224, 18.8.1990, p. 1
Council Directive 96/23/EC. Official Journal of the European Union L 125, 23.5.1996, p. 10
Council Directive 96/22/EC. Official Journal of the European Union L 125, 23.5.1996, p. 3
2002/657/EC: Commission Decision. Official Journal of the European Union L 221, 17.8.2002, p. 8
Clayton R (2005) Anal Chim Acta 529:3–6
EU Directorate General for Health and Consumers Protection, EU Directorate General for Enterprise. Reflection Paper on Residues in foodstuffs of animal origin. 2003. Available online at http://ec.europa.eu/food/food/chemicalsafety/residues/residues_paper_2003_en.pdf (accessed 3/3/2009)
Codex Alimentarius. http://www.codexalimentarius.net/web/index_es.jsp
World Health Organization. Food and Agriculture Organization of the United Nations. Understanding the Codex Alimentarius. 3rd edition. 2006. Available on line at ftp://ftp.fao.org/codex/Publications/understanding/Understanding_EN.pdf (accessed 3/3/2009)
Codex Alimentarius Commission. Codex Guidelines for the Establishment of a regulatory Programme for Control of Veterinary Drug Residues in Foods. CAC/GL 16-1993. Available on line at http://www.codexalimentarius.net/web/standard_list.do?lang=en (accessed 3/3/2009)
Codex Alimentarius Commission. Report of the 17th Session of the Codex Committee of Veterinary Drugs in Food. ALINORM 08/31/31 (2007). Available on line at http://www.codexalimentarius.net/web/archives.jsp?lang=en (accessed 3/3/2009)
Codex Alimentarius Commission. Procedural Manual. 17th edition. 2007. Available on line at http://www.codexalimentarius.net/web/procedural_manual.jsp (accessed 31/3/2009)
Thompson M, Ellison SLR, Wood R (2002) Pure Appl Chem 74:835–855
Codex Alimentarius Commission. Maximum Residue Limits for Veterinary Drugs in Foods Updated at the 31st Session of the Codex Alimentarius Commission (July 2008). CAC/MRL 02-2008. Available online at http://www.codexalimentarius.net/web/more_info.jsp?id_sta=45 (accessed 31/3/2009)
Codex Alimentarius Commission. Maximum Residue Limits for Veterinary Drugs in Foods Updated on 15th December 2006. Available online at http://www.codexalimentarius.net/mrls/vetdrugs/jsp/vetd_q=uhe.jsp (accessed 31/3/2009)
Compendium of Methods of Analysis Identified as Suitable to Support Codex MRLs. Available online at http://www.codexalimentarius.net/mrls/vetdrugs/vetd_ref/MAS-RVDF_2006_e.pdf (accessed 31/3/2009)
FAO Document Repository. Available online at http://www.fao.org/Documents/ (accessed 31/3/2009)
Regulation (EC) No 766/2006 of the European Parliament and of the Council. Official Journal of the European Union L 136, 24.5.2006, p. 3
Commission Decision 2006/130/EC. Official Journal of the European Union L 52, 23.2.2006, p. 25
International Organisation for Standardization. ISO/IEC 17025:2005 standard. General requirements for the competence of testing and calibration laboratories
European Co-operation for Accreditation (EA). http://www.european-accreditation.org/content/home/home.htm (accessed 13/4/2009)
Regulation (EC) No 765/2008 of the European Parliament and of the Council. Official Journal of the European Union L 218, 13.8.2008, p. 30
International Organisation for Standardization. ISO 9000:2005 standard. Quality management systems - Fundamentals and vocabulary
Commission Decision 97/747/EC. Official Journal of the European Union L 303, 6.11.1997, p. 12
Commission Decision 98/179/EC. Official Journal of the European Union L 65, 5.3.1998, p. 31
Directive 2003/74/EC of the European Parliament and of the Council. Official Journal of the European Union L 262, 14.10.2003, p. 17
Commission Decision 2003/181/EC. Official Journal of the European Union L 71, 15.3.2003, p. 17
Commission Decision 2004/25/EC. Official Journal of the European Union L 6, 10.1.2004, p. 38
Commission Decision 2005/34/EC. Official Journal of the European Union L 16, 20.1.2005, p. 61
Gratacós-Cubarsí M, Castellari M, Valero A, García-Regueiro JA (2006) J Chromatogr B 834:14
Font H, Adrian J, Galve R, Estévez MC, Castellari M, Gratacós-Cubarsí M, Sánchez-Baeza F, Marco MP (2008) J Agric Food Chem 56:736–743
Kaufmann A, Butcher P, Maden K, Widmer M (2007) Anal Chim Acta 586:13–21
Chiesa OA, Von Bredow J, Smith M, Heller D, Condon R, Thomas MH (2006) J Vet Pharmacol Ther 29:299–306
Commission Decision 97/747/EC Official Journal of the European Union L 303 , 06/11/1997 p. 0012 – 0015
Haughey SA, Baxter GA (2006) JAOAC Int 89:862–867
Granelli K, Branzell C (2007) Anal Chim Acta 586:289
Yamada R, Kozono M, Ohmori T, Morimatsu F, Kitayama M (2006) Biosci Biotechnol Biochem 70:54
Kauffmann A, Butcher P, Maden K, Widmer M (2008) J Chromatogr A 1194:66–79
Blasco C, Torres CM, Picó Y (2007) Trends Anal Chem 26:895–913
Stolker AAM, Zuidema T, Nielen MWF (2007) Trends Anal Chem 26:967–979
Marazuela MD, Bogialli S (2009) Anal Chim Acta 645:5–17
Haginaka J (2005) Trends Anal Chem 24:407–415
Souverain S, Rudaz S, Veuthey JL (2004) J Chromatogr B 801:141–156
Baggiani C, Anfossi L, Giovannoli C (2007) Anal Chim Acta 591:29–39
Chico J, Rubies A, Centrich F, Companyó R, Prat MD, Granados M (2008) J Chromatogr A 1213:189–199
García-Ruiz C, Marina ML (2006) Electrophoresis 27:266–282
Antignac JP, Le Bizec B, Montenau F, Andre F (2003) Anal Chim Acta 483:325–334
Kaufmann A (2009) Anal Chim Acta 637:144–155
Commission Decision 2003/181/EC Official Journal of the European Union L 71, 15.3.2003, p 17
ISO 11843 (1997) Capability of detection—Part 2: Methodology in the linear calibration case, International Organization for Standardization. Geneva, Switzerland
Guidelines for the implementation of decision 2002/657/EC SANCO/2004/2726rev2], http://ec.europa.eu/food/food/chemicalsafety/residues/cons_2002-657ec_en.pdf. (accessed 13/4/2009)
Julicher B, Gowik P, Uhlig S (1998) Analyst 123:173–179
Uhlig S, Gowik P, Radeck W (2003) Anal Chim Acta 483:351
Celeny R, Ulberth F, Gowik P, Polzer J, van Ginkel LA, Emons H (2006) Trends Anal Chem 25:927–936
IUPAC (1999) Pure Appl Chem 71:337–348
Emons H, Lisinger TPJ, Gawlik BM (2004) Trends Anal Chem 23:442–449
International Organisation for Standardization (2007) ISO/IEC Guide 99. International vocabulary of metrology - Basic and general concepts and associated terms (VIM)
Emons H (2006) Accred Qual Assur 10:690–691
Zeleny R, Ulbert F, Gowik P, Polzer J, van Ginkel LA, Emons H (2006) Trends Anal Chem 25:927–936
Gowik P, Polzer J, Uhlig S (2007) Accred Qual Assur 12:161–166
Institute for Reference Materials and Measurements. http://irmm.jrc.ec.europa.eu/html/homepage.htm (accessed 16.04.09)
The Bundesanstalt für Materialforschung und prüfung. http://www.bam.de/ (accessed 22.06.09)
Laboratory of the Government Chemist. http://www.lgc.co.uk/ (accessed 16.04.09)
European Reference Materials http://www.erm-crm.org/html/homepage.htm (accessed 16-06.09)
COMAR http://www.comar.bam.de/en/ (accessed 16.04.09)
FAPAS. http://www.fapas.com/ (accessed 13/4/2009)
Progetto Trieste. http://www.progettotrieste.com/home (accessed 13/4/2009)
AFSSA. Community Reference Laboratory for Antimicrobial Residues in Food. http://crl.fougeres.afssa.fr/ (accessed 13/4/2009)
European Proficiency Testing Information System (EPTIS) http://www.eptis.bam.de/en/about/index.htm (accessed 13/4/2009)
Acknowledgements
Financial support from the Spanish Ministerio de Ciencía y Tecnología (CiCYT Project AGL2008-05578-C05) is gratefully acknowledged
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An erratum to this article can be found at http://dx.doi.org/10.1007/s00216-009-3213-y
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Companyó, R., Granados, M., Guiteras, J. et al. Antibiotics in food: Legislation and validation of analytical methodologies. Anal Bioanal Chem 395, 877–891 (2009). https://doi.org/10.1007/s00216-009-2969-4
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DOI: https://doi.org/10.1007/s00216-009-2969-4