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Current role of LC-MS in therapeutic drug monitoring

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Abstract

The role of liquid chromatography coupled with mass spectrometry (LC-MS) techniques in routine therapeutic drug monitoring activity is becoming increasingly important. This paper reviews LC-MS methods published in the last few years for certain classes of drugs subject to therapeutic drug monitoring: immunosuppressants, antifungal drugs, antiretroviral drugs, antidepressants and antipsychotics. For each class of compounds, we focussed on the most interesting methods and evaluated the current role of LC-MS in therapeutic drug monitoring.

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  1. Department of Pharmacology-Toxicology, Limoges University Hospital, Unité INSERM U850, 87042, Limoges cedex, France

    Franck Saint-Marcoux, François-Ludovic Sauvage & Pierre Marquet

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  1. Franck Saint-Marcoux
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  2. François-Ludovic Sauvage
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  3. Pierre Marquet
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Correspondence to Pierre Marquet.

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Saint-Marcoux, F., Sauvage, FL. & Marquet, P. Current role of LC-MS in therapeutic drug monitoring. Anal Bioanal Chem 388, 1327–1349 (2007). https://doi.org/10.1007/s00216-007-1320-1

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