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Clinical Applications of Mass Spectrometry in Drug Analysis pp 1–10Cite as

Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1383))

Abstract

Mass spectrometry (MS) has been used in research and specialized clinical laboratories for decades as a very powerful technology to identify and quantify compounds. In recent years, application of MS in routine clinical laboratories has increased significantly. This is mainly due to the ability of MS to provide very specific identification, high sensitivity, and simultaneous analysis of multiple analytes (>100). The coupling of tandem mass spectrometry with gas chromatography (GC) or liquid chromatography (LC) has enabled the rapid expansion of this technology. While applications of MS are used in many clinical areas, therapeutic drug monitoring, drugs of abuse, and clinical toxicology are still the primary focuses of the field. It is not uncommon to see mass spectrometry being used in routine clinical practices for those applications.

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Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Children’s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO, USA

    Uttam Garg Ph.D.

  2. Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY, USA

    Yan Victoria Zhang Ph.D.

Authors
  1. Uttam Garg Ph.D.
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  2. Yan Victoria Zhang Ph.D.
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Corresponding author

Correspondence to Uttam Garg Ph.D. .

Editor information

Editors and Affiliations

  1. Dept of Pathology & Lab Medicine, Children's Mercy Hospitals & Clinics, Kansas City, Missouri, USA

    Uttam Garg

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Garg, U., Zhang, Y.V. (2016). Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology. In: Garg, U. (eds) Clinical Applications of Mass Spectrometry in Drug Analysis. Methods in Molecular Biology, vol 1383. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3252-8_1

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  • DOI: https://doi.org/10.1007/978-1-4939-3252-8_1

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3251-1

  • Online ISBN: 978-1-4939-3252-8

  • eBook Packages: Springer Protocols

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