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Current role of LC–MS(/MS) in doping control

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Abstract

Liquid chromatography–(tandem) mass spectrometry (LC–MS/MS) has revolutionized the detection assays used in doping control analysis over the last decade. New methods have enabled the determination of drugs that were formerly difficult to detect or undetectable at preceding sample concentrations, and complex and/or time-consuming procedures based on alternative chromatographic–mass spectrometric or immunochemical principles have been replaced by faster, more comprehensive and robust assays. A critical overview of the contributions of LC–MS(/MS) to sports drug testing is provided, including recent developments regarding low and high molecular weight drugs.

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Acknowledgments

The authors thank the Manfred-Donike Institute for Doping Analysis for supporting the presented work.

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Authors and Affiliations

  1. Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Carl-Diem-Weg 6, 50933, Cologne, Germany

    Mario Thevis & Wilhelm Schänzer

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  1. Mario Thevis
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  2. Wilhelm Schänzer
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Correspondence to Mario Thevis.

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Thevis, M., Schänzer, W. Current role of LC–MS(/MS) in doping control. Anal Bioanal Chem 388, 1351–1358 (2007). https://doi.org/10.1007/s00216-007-1131-4

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