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Detection of influenza virus: traditional approaches and development of biosensors

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Abstract

Influenza is an acute respiratory disease caused by the influenza virus. The disease occurs annually, causing fatality in the elderly and children and billions of dollars loss in business and productivity. Traditional viral detection methods include MDCK cell culture, complement fixation, hemagglutinin-inhibition, and recently RT-PCR. Although effective, these methods generally involve labor-intensive laboratory procedures and often require trained personnel to carry them out. The development of biosensor technologies will enable rapid and specific disease diagnosis on-site so that a clinician can quickly determine whether treatment is needed. This paper reviews traditional viral assays and progress in the biosensor development for influenza virus. Recent advances in single-step direct detection using non-labeling techniques such as surface plasmon resonance, quartz-crystal microbalance, and colorimetric functional polymers are discussed.

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Acknowledgements

The authors wish to acknowledge financial support from UC Riverside and an Eli Lilly Young Analyst grant.

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  1. Department of Chemistry, University of California, Riverside, CA, 92521, USA

    Yoshihisa Amano & Quan Cheng

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  1. Yoshihisa Amano
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  2. Quan Cheng
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Correspondence to Quan Cheng.

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Amano, Y., Cheng, Q. Detection of influenza virus: traditional approaches and development of biosensors. Anal Bioanal Chem 381, 156–164 (2005). https://doi.org/10.1007/s00216-004-2927-0

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