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Optical sensor systems for bioprocess monitoring

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Abstract

Bioreactors are closed systems in which microorganisms can be cultivated under defined, controllable conditions that can be optimized with regard to viability, reproducibility, and product-oriented productivity. To drive the biochemical reaction network of the biological system through the desired reaction optimally, the complex interactions of the overall system must be understood and controlled. Optical sensors which encompass all analytical methods based on interactions of light with matter are efficient tools to obtain this information. Optical sensors generally offer the advantages of noninvasive, nondestructive, continuous, and simultaneous multianalyte monitoring. However, at this time, no general optical detection system has been developed. Since modern bioprocesses are extremely complex and differ from process to process (e.g., fungal antibiotic production versus mammalian cell cultivation), appropriate analytical systems must be set up from different basic modules, designed to meet the special demands of each particular process. In this minireview, some new applications in bioprocess monitoring of the following optical sensing principles will be discussed: UV spectroscopy, IR spectroscopy, Raman spectroscopy, fluorescence spectroscopy, pulsed terahertz spectroscopy (PTS), optical biosensors, in situ microscope, surface plasmon resonance (SPR), and reflectometric interference spectroscopy (RIF).

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Authors and Affiliations

  1. Institute of Technical Chemistry, University of Hannover, Callinstr. 3, 30167, Hannover, Germany

    Roland Ulber, Jan-Gerd Frerichs & Sascha Beutel

Authors
  1. Roland Ulber
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  2. Jan-Gerd Frerichs
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  3. Sascha Beutel
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Correspondence to Roland Ulber.

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Ulber, R., Frerichs, JG. & Beutel, S. Optical sensor systems for bioprocess monitoring. Anal Bioanal Chem 376, 342–348 (2003). https://doi.org/10.1007/s00216-003-1930-1

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  • DOI: https://doi.org/10.1007/s00216-003-1930-1

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