Abstract
The extinction of conditioned fear responses entrains the formation of safe new memories to decrease those behavioral responses. The knowledge in neuronal mechanisms of extinction is fundamental in the treatment of anxiety and fear disorders. Interestingly, the use of pharmacological compounds that reduce anxiety and fear has been shown as a potent co-adjuvant in extinction therapy. However, the efficiency and mechanisms by which pharmacological compounds promote extinction of fear memories remains still largely unknown and would benefit from a validation based on functional neuronal circuits, and the neurotransmitters that modulate them. From this perspective, oxytocin receptor signaling, which has been shown in cortical and limbic areas to modulate numerous functions (Eliava et al. Neuron 89(6):1291-1304, 2016), among them fear and anxiety circuits, and to enhance the salience of social stimuli (Stoop Neuron 76(1):142-59, 2012), may offer an interesting perspective. Experiments in animals and humans suggest that oxytocin could be a promising pharmacological agent at adjusting memory consolidation to boost fear extinction. Additionally, it is possible that long-term changes in endogenous oxytocin signaling can also play a role in reducing expression of fear at different brain targets. In this review, we summarize the effects reported for oxytocin in cortico-limbic circuits and on fear behavior that are of relevance for the modulation and potential extinction of fear memories.
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Abbreviations
- ACC:
-
Anterior cingulate cortex
- AVP1a-R:
-
Vasopressin receptor
- BA:
-
Basal amygdala
- BLA:
-
Basolateral amygdala
- CBT:
-
Cognitive behavioral therapy
- CeA:
-
Central amygdala
- CeL:
-
Centro-lateral amygdala
- CeM:
-
Centro-medial amygdala
- CS:
-
Conditioned stimulus
- CSF:
-
Cerebrospinal fluid
- dmPFC:
-
Dorso-medial prefrontal cortex
- GABA:
-
Gamma amino butyric acid
- IL:
-
Infralimbic cortex
- ITCd:
-
Intercalated cell masses (dorsal)
- ITCv:
-
Intercalated cell masses (ventral)
- LA:
-
Lateral amygdala
- NMDAR:
-
N-methyl-d-aspartate receptor
- Nacc:
-
Nucleus accumbens
- OT:
-
Oxytocin
- OTR:
-
Oxytocin receptor
- PKCδ:
-
Protein kinase delta
- PL:
-
Prelimbic cortex
- PTSD:
-
Posttraumatic stress disorder
- PVN:
-
Paraventricular nucleus of the hypothalamus
- US:
-
Unconditioned stimulus
- vmPFC:
-
Ventromedial prefrontal cortex
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RT is supported by the Synapsis Foundation, CH by a Marie-Heim Vögtlin grant from the Swiss National Science Foundation, and EvdB by a Swiss Federal grant from the Commission of Technology and Innovation.
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Triana-Del Río, R., van den Burg, E., Stoop, R. et al. Acute and long-lasting effects of oxytocin in cortico-limbic circuits: consequences for fear recall and extinction. Psychopharmacology 236, 339–354 (2019). https://doi.org/10.1007/s00213-018-5030-5
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DOI: https://doi.org/10.1007/s00213-018-5030-5