Skip to main content
SpringerLink
Log in

5-HT7 receptor activation: procognitive and antiamnesic effects

  • Original Investigation
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Rationale

The serotonin (5-hydroxytryptamine (5-HT)) 5-HT7 receptor is localized in brain areas mediating memory; however, the role of this receptor on memory remains little explored.

Objective

First, demonstrating the associative nature of Pavlovian/instrumental autoshaping (P/I-A) task, rats were exposed (three sessions) to CS-US (Pavlovian autoshaping), truly random control, free operant, and presentations of US or CS, and they were compared with rats trained-tested for one session to the P/I-A procedure. Also, effects of the 5-HT7 receptor agonist LP-211 administered intraperitoneally after training was determined on short- (1.5 h) and long-term memory 24 and 48 h) and on scopolamine-induced memory impairment and cAMP production.

Methods

Autoshaping and its behavioral controls were studied. Other animals were subjected to an autoshaping training session and immediately afterwards were given (intraperitoneal) vehicle or LP-211 (0.1–10 mg/kg) and/or scopolamine (0.2 mg/kg) and tested for short-term memory (STM) and long-term memory (LTM); their brains were extracted for the cAMP ELISA immunoassay.

Results

P/I-A group produced the higher %CR. LP-211 did not affect STM; nonetheless, at 0.5 and 1.0 mg/kg, it improved LTM. The 5-HT7 receptor antagonist SB-269970 (SB; 10.0 mg/kg) alone had no effect; nevertheless, the LP-211 (1.0 mg/kg) LTM facilitation was reversed by SB. The scopolamine (0.2 mg/kg) induced-decrement in CR was accompanied by significant increased cAMP production. The scopolamine-induced decrement in CR and increments in cAMP were significantly attenuated by LP-211.

Conclusions

Autoshaping is a reliable associative learning task whose consolidation is facilitated by the 5-HT7 receptor agonist LP-211.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  • Adriani W, Travaglini D, Lacivita E, Saso L, Leopoldo M, Laviola G (2012) Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice. Neuropharmacology 62(2):833–842

    Article  CAS  PubMed  Google Scholar 

  • Atnip GW (1977) Stimulus– and response–reinforcer contingencies in autoshaping, operant, classical, and omission training procedures in rats. J Exp Anal Behav 28(1):59–69

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Ballaz SJ, Akil H, Watson SJ (2007) Analysis of 5-HT6 and 5-HT7 receptor gene expression in rats showing differences in novelty-seeking behavior. Neuroscience 149(1):192–202

    Article  CAS  PubMed  Google Scholar 

  • Barrett JE, Vanover KE (2004) Assessment of learning and memory using the autoshaping of operant responding in mice. Curr Protoc Neurosci;Chapter 8:

  • Brown PL, Jenkins HM (1968) Auto-shaping of the pigeon's key-peck. J Exp Anal Behav 11(1):1–8

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Buhot MC, Wolff M, Segu L (2003) Serotonin. In: Riedel G, Platt B (eds) Memories are made of these: from messengers to molecules. Eurekah.com and Kluwer Academic/Plenum Publishers, Amsterdam, pp 1–19

    Google Scholar 

  • Bussey TJ, Holmes A, Lyon L, Mar AC, McAllister KA, Nithianantharajah J, Oomen CA, Saksida LM (2012) New translational assays for preclinical modelling of cognition in schizophrenia: the touchscreen testing method for mice and rats. Neuropharmacology 62(3):1191–1203

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Carballosa Gonzalez MM, Blaya MO, Alonso OF, Bramlett HM, Hentall ID (2013) Midbrain raphe stimulation improves behavioral and anatomical recovery from fluid-percussion brain injury. J Neurotrauma 30(2):119–130

    Article  PubMed Central  PubMed  Google Scholar 

  • Cook RG, Geller AI, Zhang GR, Gowda R (2004) Touchscreen-enhanced visual learning in rats. Behav Res Methods Instrum Comput 36(1):101–106

    Article  PubMed  Google Scholar 

  • Da Silva Costa-Aze V, Quiedeville A, Boulouard M, Dauphin F (2012) 5-HT6 receptor blockade differentially affects scopolamine-induced deficits of working memory, recognition memory and aversive learning in mice. Psychopharmacology (Berl) 222(1):99–115

    Article  Google Scholar 

  • De Filippis B, Nativio P, Fabbri A, Ricceri L, Adriani W, Lacivita E, Leopoldo M, Passarelli F, Fuso A, Laviola G (2014) Pharmacological stimulation of the brain serotonin receptor 7 as a novel therapeutic approach for Rett syndrome. Neuropsychopharmacology. doi:10.1038/ npp.2014.105

    PubMed  Google Scholar 

  • Deckner CW, Wilcox LM, Maisto SA, Blanton RL (1980) Autoshaping of abnormal children. J Abnorm Child Psychol 8(3):339–350

    Article  CAS  PubMed  Google Scholar 

  • Eriksson TM, Holst S, Stan TL, Hager T, Sjögren B, Ogren SÖ, Svenningsson P, Stiedl O (2012) 5-HT1A and 5-HT7 receptor crosstalk in the regulation of emotional memory: implications for effects of selective serotonin reuptake inhibitors. Neuropharmacology 63(6):1150–1160

    Article  CAS  PubMed  Google Scholar 

  • Frankland PW, Bontempi B, Talton LE, Kaczmarek L, Alcino J, Silva AS (2004) The involvement of the anterior cingulated cortex in remote contextual fear memory. Science 304:881–883

    Article  CAS  PubMed  Google Scholar 

  • Freret T, Paizanis E, Beaudet G, Gusmao-Montaigne A, Nee G, Dauphin F, Bouet V, Boulouard M (2014) Modulation of 5-HT7 receptor: effect on object recognition performances in mice. Psychopharmacology 231(2):393–400

    Article  CAS  PubMed  Google Scholar 

  • Gallistel CR, Fairhurst S, Balsam P (2004) The learning curve: implications of a quantitative analysis. Proc Natl Acad Sci U S A 101(36):13124–13131

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Gasbarri A, Cifariello A, Pompili A, Meneses A (2008) Effect of 5-HT7 antagonist SB-269970 in the modulation of working and reference memory in the rat. Behav Brain Res 195(1):164–70

  • Gasbarri A, Pompili A (2014) Serotonergic 5-HT7 receptors and cognition. Rev Neurosci 25(3):311–325

    Article  CAS  PubMed  Google Scholar 

  • Gellynck E, Heyninck K, Andressen KW, Haegeman G, Levy FO, Vanhoenacker P, Van Craenenbroeck K (2013) The serotonin 5-HT7 receptors: two decades of research. Exp Brain Res. [Epub ahead of print] PMID: 24042216

  • Goshen I, Brodsky M, Prakash R, Wallace J, Gradinaru V, Ramakrishnan C, Deisseroth K (2011) Dynamics of retrieval strategies for remote memories. Cell 147(3):678–689

    Article  CAS  PubMed  Google Scholar 

  • Haahr ME, Fisher P, Holst K, Madsen K, Jensen CG, Marner L, Lehel S, Baaré W, Knudsen G, Hasselbalch S (2013) The 5-HT4 receptor levels in hippocampus correlates inversely with memory test performance in humans. Hum Brain Mapp 34(11):3066–3074

    Article  PubMed  Google Scholar 

  • Hannon J, Hoyer D (2008) Molecular biology of 5-HT receptors. Behav Brain Res 195(1):198–213

    Article  CAS  PubMed  Google Scholar 

  • Harvey JA (1996) Serotonergic regulation of associative learning. Behav Brain Res 73(1–2):47–50

  • Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R (2010) LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor. Neurosci Lett 481(1):12–16

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Herrick-Davis K (2013) Functional significance of serotonin receptor dimerization. Exp Brain Res 230(4):375–386

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Horiguchi M, Huang M, Meltzer HY (2011) The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. J Pharmacol Exp Ther 338(2):605–614

    Article  CAS  PubMed  Google Scholar 

  • Horner AE, Heath CJ, Hvoslef-Eide M, Kent BA, Kim CH, Nilsson SR, Alsiö J, Oomen CA, Holmes A, Saksida LM, Bussey TJ (2013) The touchscreen operant platform for testing learning and memory in rats and mice. Nat Protoc 8(10):1961–1984

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hotte M, Dauphin F, Freret T, Boulouard M, Levallet G (2012) A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat. PLoS One 7(2):e32244

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Izquierdo I, Bevilaqua LR, Rossato JI, Bonini JS, Medina JH, Cammarota M (2006) Different molecular cascades in different sites of the brain control memory consolidation. Trends Neurosci 29(9):496–505

    Article  CAS  PubMed  Google Scholar 

  • Izquierdo I, Medina JH, Vianna MR, Izquierdo LA, Barros DM (1999) Separate mechanisms for shortand long-term memory. Behav Brain Res 103(1):1–11

  • Kandel ER (2001) A dialogue between genes and synapses. The molecular biology of memory storage. Science 294:1030–1038

    Article  CAS  PubMed  Google Scholar 

  • Lacivita E, Di Pilato P, Stama ML, Colabufo NA, Berardi F, Perrone R, De Filippis B, Laviola G, Adriani W, Niso M, Leopoldo M (2013) Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties. Bioorg Med Chem Lett 23(22):6083–6086

    Article  CAS  PubMed  Google Scholar 

  • Leopoldo M, Lacivita E, Berardi F, Perrone R, Hedlund PB (2011) Serotonin 5-HT7 receptor agents: structure–activity relationships and potential therapeutic applications in central nervous system disorders. Pharmacol Ther 129(2):120–148

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Lesaint F, Sigaud O, Flagel SB, Robinson TE, Khamassi M (2014) Modelling individual differences in the form of Pavlovian conditioned approach responses: a dual learning systems approach with factored representations. PLoS Comput Biol 10(2):e1003466

    Article  PubMed Central  PubMed  Google Scholar 

  • Lindner MD, Hodges DB Jr, Hogan JB, Orie AF, Corsa JA, Barten DM, Polson C, Robertson BJ, Guss VL, Gillman KW, Starrett JE Jr, Gribkoff VK (2003) An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning. J Pharmacol Exp Ther 307(2):682–691

    Article  CAS  PubMed  Google Scholar 

  • Lorenzini CGA, Baldi E, Bucherelli C, Sacchetti B, Tassoni G (1999) Neural topography and chronology of memory consolidation: a review of functional inactivation findings. Neurobiol Learn Mem 71:1–18

    Article  Google Scholar 

  • Lynch MA (2004) Long-term potentiation and memory. Physiol Rev 84:87–136

  • Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, Hall WJ, Fisher SG, Peterson DR, Haley JM, Nazar MD, Rich SA, Berlau DJ, Peltz CB, Tan MT, Kawas CH, Federoff HJ (2014) Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. doi:10.1038/nm.3466

    PubMed  Google Scholar 

  • Marcos B, García-Alloza M, Gil-Bea FJ, Chuang TT, Francis PT, Chen CP, Tsang SW, Lai MK, Ramirez MJ (2008) Involvement of an altered 5-HT6 receptor function in behavioral symptoms of Alzheimer's disease. J Alzheimer's Dis 14:43–50

    CAS  Google Scholar 

  • Markou A, Salamone JD, Bussey TJ, Mar AC, Brunner D, Gilmour G, Balsam P (2013) Measuring reinforcement learning and motivation constructs in experimental animals: relevance to the negative symptoms of schizophrenia. Neurosci Biobehav Rev 37(9 Pt B):2149–2165

    Article  PubMed  Google Scholar 

  • Martínez M, Hernández AI, Hernanz A (2001) Increased cAMP immunostaining in cerebral vessels in Alzheimer's disease. Brain Res 922(1):148–152

    Article  PubMed  Google Scholar 

  • Matthys A, Haegeman G, Van Craenenbroeck K, Vanhoenacker P (2011) Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives. Mol Neurobiol 43(3):228–253

    Article  CAS  PubMed  Google Scholar 

  • Meneses A (2003) A pharmacological analysis of an associative learning task: 5-HT1 to 5-HT7 receptor subtypes function on a Pavlovian/instrumental autoshaped memory. Learn Mem 10(5):363–372

    Article  PubMed Central  PubMed  Google Scholar 

  • Meneses A (2013) 5-HT systems: emergent targets for memory formation and memory alterations. Rev Neurosci 24(6):629–664

    Article  CAS  PubMed  Google Scholar 

  • Meneses A (2014a) Memory formation and memory alterations: 5-HT6 and 5-HT7 receptors, novel alternative. Rev Neurosci 25(3):325–356

    CAS  PubMed  Google Scholar 

  • Meneses A (2014b) 5-HT7 receptor stimulation and blockade: a therapeutic paradox about memory formation and amnesia. Front Behav Neurosci. doi:10.3389/fnbeh.2014.00207

    PubMed Central  PubMed  Google Scholar 

  • Millan MJ, Agid Y, Brüne M, Bullmore ET, Carter CS, Clayton NS, Connor R, Davis S, Deakin B, DeRubeis RJ, Dubois B, Geyer MA, Goodwin GM, Gorwood P, Jay TM, Joëls M, Mansuy IM, Meyer-Lindenberg A, Murphy D, Rolls E, Saletu B, Spedding M, Sweeney J, Whittington M, Young LJ (2012) Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov 11(2):141–168 

    Article  CAS  PubMed  Google Scholar 

  • Myer JS, Hull JH (1974) Autoshaping and instrumental learning in the rat. J Comp Physiol Psychol 86(4):724–729

    Article  Google Scholar 

  • Myhrer T (2003) Neurotransmitter systems involved in learning and memory in the rat: a meta-analysis based on studies of four behavioral tasks. Brain Res Brain Res Rev 41(2–3):268–287

  • Nikiforuk A, Popik P (2013) Amisulpride promotes cognitive flexibility in rats: the role of 5-HT7 receptors. Behav Brain Res 248:136–140

    Article  CAS  PubMed  Google Scholar 

  • Oscos A, Martinez JL Jr, McGaugh JL (1988) Effects of post-training d-amphetamine on acquisition of an appetitive autoshaped lever press response in rats. Psychopharmacology (Berl) 95(1):132–134

    Article  CAS  Google Scholar 

  • Paxinos G, Watson C (2005) The rat brain. Elsevier Academic Press, Burlington

    Google Scholar 

  • Peele DB, Vincent A (1989) Strategies for assessing learning and memory, 1978–1987: a comparison of behavioral toxicology, psychopharmacology, and neurobiology. Neurosci Biobehav Rev 13(4):317–322

  • Pittala V, Pittala D (2011) Latest advances towards the discovery of 5-HT7 receptor ligands. Mini Rev Med Chem 11(13):1108–1121

    Article  CAS  PubMed  Google Scholar 

  • Reichel CM, Gilstrap MG, Ramsey LA, See RE (2014) Modafinil restores methamphetamine induced object-in-place memory deficits in rats independent of glutamate N-methyl-d-aspartate receptor expression. Drug Alcohol Depend 134:115–122

    Article  CAS  PubMed  Google Scholar 

  • Renner U, Zeug A, Woehler A, Niebert M, Dityatev A, Dityateva G, Gorinski N, Guseva D, Abdel-Galil D, Fröhlich M, Döring F, Wischmeyer E, Richter DW, Neher E, Ponimaskin EG (2012) Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking. J Cell Sci 125(Pt 10):2486–2499

    Article  CAS  PubMed  Google Scholar 

  • Rescorla RA (1967) Pavlovian conditioning and its proper control procedures. Psychol Rev 74:71–80

    Article  CAS  PubMed  Google Scholar 

  • Roberts AJ, Hedlund PB (2012) The 5-HT7 receptor in learning and memory. Hippocampus 22(4):762–771

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Rodriguez JS, Boctor SY, Phelix CF, Martinez JL Jr (2008) Differences in performance between Sprague–Dawley and Fischer 344 rats in positive reinforcement tasks. Pharmacol Biochem Behav 89(1):17–22

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Rodríguez JJ, Noristani HN, Verkhratsky A (2012) The serotonergic system in ageing and Alzheimer's disease. Prog Neurobiol 99:15–41

    Article  PubMed  Google Scholar 

  • Ruocco LA, Treno C, Gironi Carnevale UA, Arra C, Boatto G, Nieddu M, Pagano C, Illiano P, Barbato F, Tino A, Carboni E, Laviola G, Lacivita E, Leopoldo M, Adriani W, Sadile AG (2014) Prepubertal stimulation of 5-HT7-R by LP-211 in a rat model of hyper-activity and attention-deficit: permanent effects on attention, brain amino acids and synaptic markers in the fronto-striatal interface. PLoS One 9(4):e83003

    Article  PubMed Central  PubMed  Google Scholar 

  • Saitoh Y, Inokuchi K (2000) A triphasic curve characterizes the retention of lever-pressing behavior rewarded by lateral hypothalamic stimulation during the immediate-post-trial period in rats: implications for a transient-intermediate stage between short- and long-term memory. Neurosci Res 37(3):211–219

    Article  CAS  PubMed  Google Scholar 

  • Saroja SR, Kim EJ, Shanmugasundaram B, Höger H, Lubec G (2014) Hippocampal monoamine receptor complex levels linked to spatial memory decline in the aging C57BL/6J. Behav Brain Res 264:1–8

    Article  CAS  PubMed  Google Scholar 

  • Seyedabadi M, Fakhfouri G, Ramezani V, Mehr SE, Rahimian R (2014) The role of serotonin in memory: interactions with neurotransmitters and downstream signaling. Exp Brain Res 232(3):723–738

    Article  CAS  PubMed  Google Scholar 

  • Sparber SB (2001) Use of autoshaping with non-delayed and delayed reinforcement for studying effects upon acquisition and consolidation of information. In: Buccafusco JJ (ed) Methods of behavior analysis. CRC press, Boca Raton, pp 232–267

    Google Scholar 

  • Speranza L, Chambery A, Di Domenico M, Crispino M, Severino V, Volpicelli F, Leopoldo M, Bellenchi GC, di Porzio U, Perrone-Capano C (2013) The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways. Neuropharmacology 67:155–167

    Article  CAS  PubMed  Google Scholar 

  • Stahlman WD, Young ME, Blaisdell AP (2010) Response variability in pigeons in a Pavlovian task. Learn Behav 38(2):111–118

    Article  PubMed  Google Scholar 

  • Steckler T, Andrews JS, Marten P, Turner JD (1993) Effects of NBM lesions with two neurotoxins on spatial memory and autoshaping. Pharmacol Biochem Behav 44:877–889

    Article  CAS  PubMed  Google Scholar 

  • Talpos JC, Fletcher AC, Circelli C, Tricklebank MD, Dix SL (2012) The pharmacological sensitivity of a touchscreen-based visual discrimination task in the rat using simple and perceptually challenging stimuli. Psychopharmacology (Berl) 221(3):437–449

    Article  CAS  Google Scholar 

  • Thomas DR, Hagan JJ (2004) 5-HT7 receptors. Curr Drug Targets CNS Neurol Disord 3(1):81–90

    Article  CAS  PubMed  Google Scholar 

  • Thomas KL and Everitt BJ (2001) Limbic-cortical-ventral striatal activation during retrieval of a discrete cocaine-associated stimulus: a cellular imaging study with g protein kinase C expression. J. Neurosci 1:2526–2535

  • Tomie A, Di Poce J, Aguado A, Janes A, Benjamín D and Pohorecky L (2003) Effects of autoshaping procedures on 3H-8-OH-DPAT-labeled 5-HT1a binding and 125I-LSD-labeled 5-HT2a binding in the rat brain. Brain Res 975:167–178

  • Tomie A, Lincks M, Nadarajah SD, Pohorecky LA, Yu L (2012) Pairings of lever and food induce Pavlovian conditioned approach of sign-tracking and goal-tracking in C57BL/6 mice. Behav Brain Res 226(2):571–578

    Article  PubMed Central  PubMed  Google Scholar 

  • Vanover KE, Barrett JE (1998) An automated learning and memory model in mice: pharmacological and behavioral evaluation of an autoshaped response. Behav Pharmacol 9(3):273–283

    CAS  PubMed  Google Scholar 

  • Vanover KE, Harvey SC, Son T, Bradley SR, Kold H, Makhay M, Veinbergs I, Spalding TA, Weiner DM, Andersson CM, Tolf BR, Brann MR, Hacksell U, Davis RE (2004) Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist. J Pharmacol Exp Ther 310(3):943–951

    Article  CAS  PubMed  Google Scholar 

  • Wang ZZ, Zhang Y, Liu YQ, Zhao N, Zhang YZ, Yuan L, An L, Li J, Wang XY, Qin JJ, Wilson SP, O'Donnell JM, Zhang HT, Li YF (2013) RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects. Br J Pharmacol 168(4):1001–1014

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Woods S, Clarke N, Layfield R, Fone K (2012) 5-HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms. Br J Pharmacol 167(2):436–449

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported in part supported by CONACYT grant 80060.

Author information

Authors and Affiliations

  1. Depto. de Farmacobiología, CINVESTAV-IPN, México City, México

    A. Meneses & G. Perez-Garcia

  2. Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Huixquilucan, Edo. de México, Mexico

    G. Liy-Salmeron & T. Ponce-López

  3. Dipartimento di Farmacia–Scienze del Farmaco, Universitá degli Studi di Bari “A Moro”, via Orabona 4, Bari, 70125, Italy

    E. Lacivita & M. Leopoldo

  4. Tenorios 235, Granjas Coapa, Mexico City, 14330, Mexico

    A. Meneses

Authors
  1. A. Meneses
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Perez-Garcia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Liy-Salmeron
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Ponce-López
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Lacivita
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Leopoldo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Meneses.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Meneses, A., Perez-Garcia, G., Liy-Salmeron, G. et al. 5-HT7 receptor activation: procognitive and antiamnesic effects. Psychopharmacology 232, 595–603 (2015). https://doi.org/10.1007/s00213-014-3693-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00213-014-3693-0

Keywords

Search

Navigation