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The role of hippocampal 5-HT1D and 5-HT1F receptors on learning and memory in rats

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Abstract

Serotonin is a neurotransmitter, which is involved in memory via its receptors. The 5-HT1D and 5-HT1F receptors mainly exist in the hippocampus, which plays an important role in memory processing. However, few studies have assessed the effect of these serotonin receptors on memory. We evaluated the effect of a 5-HT1D receptor agonist, PNU142633, 5-HT1D receptor antagonist, BRL15572 hydrochloride, and 5-HT1F receptor agonist, LY344864, on the recognition and avoidance memory in the hippocampus area. Fifty adult male Wistar rats weighing 200–250 g were divided into the control, sham-operated, PNU, BRL, and LY groups (n=10 per group). Bilateral guide cannulas were implanted into the dentate gyrus area of the hippocampus. The drugs were administered at the dose of 1 μg/μl before the novel object recognition (NOR) and passive avoidance learning (PAL) tests. The results showed that in the NOR test, the administration of PNU and LY had no significant effect on recognition index; however, the recognition index was increased by BRL. In the PAL test, the administration of PNU had no significant effect on recognition index, but the administration of BRL and LY increased the time spent in the dark compartment of the apparatus and decreased the step-through latency into the dark compartment apparatus. It can be concluded that the inhibition of the hippocampal 5-HT1D receptor improved cognition memory but impaired avoidance memory. Activation of the hippocampal 5-HT1F receptor had no effect on cognitive memory but impaired avoidance memory.

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Funding

This study was funded by a grant (Grant Number: 9410015225) of the Hamadan University of Medical Sciences, Hamadan, Iran.

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Authors and Affiliations

  1. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Simin Afshar, Siamak Shahidi, Nasrin Hashemi-Firouzi & Alireza Komaki

  2. School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Hemen Baooshi, Mahdieh Hoseini & Mahsa Esmaeili

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  1. Simin Afshar
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Contributions

Simin Afshar, Nasrin Hashemi-Firouzi, and Siamak Shahidi contributed to study design and conducted the experiments. Hemen Baooshi, Mahdieh Hoseini, and Mahsa Esmaeili performed the experiments. Simin Afshar and Nasrin Hashemi-Firouzi contributed to analyze and interpret the data. Nasrin Hashemi-Firouzi and Siamak Shahidi wrote the main manuscript and editing. Siamak Shahidi was responsible for the funding. Alireza Komaki provided the technical assistance.

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Afshar, S., Shahidi, S., Baooshi, H. et al. The role of hippocampal 5-HT1D and 5-HT1F receptors on learning and memory in rats. Naunyn-Schmiedeberg's Arch Pharmacol 396, 1451–1460 (2023). https://doi.org/10.1007/s00210-023-02411-x

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