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Simultaneous blockade of dopamine and noradrenaline reuptake promotes disadvantageous decision making in a rat gambling task

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Abstract

Rationale

The inability to make profitable long-term decisions has been implicated in several psychiatric disorders. There is emerging evidence to support a role for dopamine (DA) in decision making, but our understanding of the role of noradrenaline (NA) and serotonin (5-HT) in decision making, and of possible interactions between the three monoamines, is limited. Moreover, impulsivity has been associated with aberrant decision making, but the underlying mechanisms are incompletely understood.

Objective

The purpose of this study is to improve our understanding of the neuropharmacological mechanisms of decision making and impulse control.

Methods

We investigated the effects of amphetamine (0.25–1.0 mg/kg) and selective reuptake inhibitors of DA (GBR12909; 2.5–10 mg/kg), NA (atomoxetine; 0.3–3.0 mg/kg), and 5-HT (citalopram; 0.3–3.0 mg/kg) in a rat gambling task (rGT). Since the rGT allows for detection of impulsive action, i.e., premature responding, we also assessed the relationship between decision making and impulsivity.

Results

In the rGT, rats developed an optimal choice strategy from the first session onwards. Elevation of endogenous DA or NA levels increased and decreased impulsivity, respectively, but did not alter decision making. However, simultaneous blockade of DA and NA disrupted decision making, reflected by a relative decrease in choice for the advantageous choice options. Increasing 5-HT neurotransmission did not affect decision making or impulsivity.

Conclusions

These data suggest important but complementary or redundant roles of DA and NA neurotransmission in decision-making processes based on reward probability and punishment. Moreover, impulse control and decision making in the rGT rely on dissociable mechanisms.

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Acknowledgments

This study was supported by the National Institute on Drug Abuse Grant R01 DA022628 (L.J.M.J.V.).

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Authors and Affiliations

  1. Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands

    Petra J. J. Baarendse & Louk J. M. J. Vanderschuren

  2. Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

    Louk J. M. J. Vanderschuren

  3. Department of Psychology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada

    Catharine A. Winstanley

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  1. Petra J. J. Baarendse
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  2. Catharine A. Winstanley
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Correspondence to Louk J. M. J. Vanderschuren.

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Baarendse, P.J.J., Winstanley, C.A. & Vanderschuren, L.J.M.J. Simultaneous blockade of dopamine and noradrenaline reuptake promotes disadvantageous decision making in a rat gambling task. Psychopharmacology 225, 719–731 (2013). https://doi.org/10.1007/s00213-012-2857-z

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