Abstract
Rationale
Several studies with nonhumans and humans have shown that stimulants decrease impulsive choices on delay-to-reinforcement (self-control) procedures. Little is known, however, about the effects of the stimulant methylphenidate on choice for delayed reinforcers in humans.
Objectives
The present study was designed to investigate the effects of acute methylphenidate administrations on impulsive responding in adult humans on a delay-to-reinforcement task.
Methods
Eleven adult males with a history of criminal behavior but no history of attention–deficit hyperactivity disorder (ADHD) participated. Impulsive responding was measured using an adjusting-delay procedure in which subjects were presented with repeated choices between a small amount of money delivered after a short delay and a larger amount of money delivered after a delay that adjusted as a function of previous choices. Subjects were exposed to four experimental sessions each day of participation and 60 min prior to the first daily session received placebo or 0.15, 0.30, or 0.60 mg/kg methylphenidate. Stable choice patterns were re-established between each methylphenidate dose.
Results
Individuals differed in their sensitivity to methylphenidate, but in over half of the subjects methylphenidate decreased impulsive (i.e., increased the number of self-control choices) and increased the delay to the large reinforcer. The largest increases in self-control choices tended to occur at the 0.30-mg/kg and 0.60-mg/kg doses, and the effects often persisted across multiple daily sessions. In six subjects, under at least one methylphenidate dose, the number of impulsive choices decreased to zero.
Conclusions
Acute methylphenidate administrations tended to decrease the number of impulsive choices in adult humans on an adjusting-delay procedure, although there were substantial individual differences in the sensitivity of choice to methylphenidate. In no case, however, did methylphenidate increase impulsive choices. These results are consistent with several recent laboratory studies with nonhumans and humans showing that stimulants increase preference for large, delayed reinforcers.
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References
Ainslie GW (1974) Impulse control in pigeons. J Exp Anal Behav 21:485–489
Barkley RA (1977) A review of stimulant drug research with hyperactive children. J Child Psychol Psychiatry 18:137–165
Barratt ES (1985) Impulsiveness defined within a systems model of personality. In: Spielberger ED, Butcher JN (eds) Advances in personality assessment, vol 5. Erlbaum, Hillsdale, pp 113–132
Bickel WK, Marsch LA (2001) Toward a behavioral economic understanding of drug dependence: delay discounting processes. Addiction 96:73–86
Brown RT, Borden KA, Wynne ME, Schleser R, Clingerman SR (1986) Methylphenidate and cognitive therapy with ADD children: a methodological reconsideration. J Abnorm Child Psychol 14:481–497
Campbell M, Cueva JE, Adams PB (1999) Pharmacotherapy of impulsive-aggressive behavior. In: Cloninger CR (ed) Personality and psychopathology. American Psychiatric Press, Washington, pp 431–455
Cardinal RN, Robbins TW, Everitt BJ (2000) The effects of d-amphetamine, chlordiazepoxide, α-flupenthixol and behavioural manipulations on choice of signalled and unsignalled delayed reinforcement in rats. Psychopharmacology 152:362–375
Charrier D, Thiébot MH (1996) Effects of psychotropic drugs on rats responding in an operant paradigm involving choice between delayed reinforcers. Pharmacol Biochem Behav 54:149–157
Cherek DR (1992) The point subtraction aggression paradigm (PSAP). University of Texas Press, Houston
Cherek DR, Lane SD (1999a) Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder. Psychopharmacology 146:473–481
Cherek DR, Lane SD (1999b) Laboratory and psychometric measurements of impulsivity among violent and nonviolent female parolees. Biol Psychiatry 46:273–280
Cherek DR, Lane SD (2000) Fenfluramine effects on impulsivity in a sample of adults with and without history of conduct disorder. Psychopharmacology 152:149–156
Cherek DR, Moeller FG, Dougherty DM, Rhoades H (1997) Studies of violent and nonviolent male parolees. II. Laboratory and psychometric measurements of impulsivity. Biol Psychiatry 41:523–529
Cherek DR, Lane SD, Pietras CJ, Sharon J, Steinberg JL (2002) Acute effects of baclofen, a γ-aminobutyric acid-B agonist, on laboratory measures of aggressive and escape responses of adult male parolees with and without a history of conduct disorder. Psychopharmacology 164:160–167
De Wit H, Enggasser JL, Richards JB (2002) Acute administration of d-amphetamine decreases impulsivity in healthy volunteers. Neuropsychopharmacology 27:813–825
Dougherty DM, Bjork JM, Marsh DM, Moeller FG (2000) A comparison between adults with conduct disorder and normal controls on a continuous performance test: differences in impulsive response characteristics. Psychol Rec 50:203–219
Evenden JL (1999) Varieties of impulsivity. Psychopharmacology 146:348–361
Evenden JL, Ryan CN (1996) The pharmacology of impulsive behaviour in rats: the effects of drugs on response choice with varying delays of reinforcement. Psychopharmacology 128:161–170
Findling RL, Dogin JW (1998) Psychopharmacology of ADHD: children and adolescents. J Clin Psychiatry 59[Suppl 7]:42–49
First MB, Spitzer RL, Gibbon M, Williams JBW (1996) Structured clinical interview for DSM-IV axis I disorders. Biometrics Research Department. State Psychiatric Institute, New York
Flora SR, Pavlik WB (1992) Human self-control and the density of reinforcement. J Exp Anal Behav 57:201–208
Hinshaw SP, Lee SS (2000) Ritalin effects on aggression and antisocial behavior. In: Greenhill LL, Osman BB (eds) Ritalin: theory and practice, 2nd edn. Liebert, New York, pp 237–251
Ito M, Nakamura K (1998) Humans' choice in a self-control choice situation: sensitivity to reinforcer amount, reinforcer delay, and overall reinforcement density. J Exp Anal Behav 69:87–102
Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988
Klein RG, Abikoff H, Klass E, Ganeles D, Seese LM, Pollack S (1997) Clinical efficacy of methylphenidate in conduct disorder with and without attention deficit hyperactivity disorder. Arch Gen Psychiatry 54:1073–1080
Kuczenski R, Segal DS (2001) Locomotor effects of acute and repeated threshold doses of amphetamine and methylphenidate: relative roles of dopamine and norepinephrine. J Pharmacol Exp Ther 296:876–883
Logue AW (1988) Research on self-control: an integrating framework. Behav Brain Sci 11:665–709
Logue AW (2000) Self-control and health behavior. In: Bickel WK, Vuchinich RE (eds) Reframing health behavior change with behavioral economics. Erlbaum, New Jersey, pp 167–192
Logue AW, Peña-Correal TE, Rodriguez ML, Kabela E (1986) Self-control in adult humans: variation in positive reinforcer amount and delay. J Exp Anal Behav 46:159–173
Logue AW, King GR, Chavarro A, Volpe JS (1990) Matching and maximizing in a self-control paradigm using human subjects. Learn Motivation 21:340–368
Mazur JE, Logue AW (1978) Choice in a "self-control" paradigm: effects of a fading procedure. J Exp Anal Behav 30:11–17
Patrick KS, Mueller RA, Gualtieri CT, Breese GR (1987) Pharmacokinetics and actions of methylphenidate. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress. Raven Press, New York, pp 1387–1395
Rachlin H, Green L (1972) Commitment, choice and self-control. J Exp Anal Behav 17:15–22
Rapoport JI, Buchsbaum MS, Weingartner H, Zahn TP, Ludlow C, Mikkelsen EJ (1980) Dextroamphetamine. Its cognitive and behavioral effects in normal and hyperactive boys and normal men. Arch Gen Psychiatry 37:933–943
Rapport MD, Stoner G, DuPaul GJ, Kelly KL, Tucker SB, Schoeler T (1988) Attention deficit disorder and methylphenidate: a multilevel analysis of dose-response effects on children's impulsivity across settings. J Am Acad Child Adolesc Psychiatry 27:60–69
Riccio CA, Waldrop JJM, Reynolds CR, Lowe P (2001) Effects of stimulants on the continuous performance test (CPT): implications for CPT use and interpretation. J Neuropsychiatry Clin Neurosci 13:326–335
Richards JB, Sabol KE, de Wit H (1999) Effects of methamphetamine on the adjusting amount procedure, a model of impulsive behavior in rats. Psychopharmacology 146:432–439
Robbins TW (1975) The potentiation of conditioned reinforcement by psychomotor stimulant drugs. A test of Hill's hypothesis. Psychopharmacologia 45:103–114
Robbins TW (1978) The acquisition of responding with conditioned reinforcement: effect of pipradrol, methylphenidate, d-amphetamine, and nomifensine. Psychopharmacology 58:79–87
Shipley Boyle B (1967) The Shipley institute of living scale. Western Psychological Services, Los Angeles, CA
Solanto MV (1998) Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behav Brain Res 94:127–152
Solanto MV (2002) Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research. Behav Brain Res 130:65–71
Solanto MV, Conners CK (1982) A dose-response and time-action analysis of autonomic and behavioral effects of methylphenidate in attention deficit disorder with hyperactivity. Psychophysiology 19:658–667
Solanto MV, Wender EH, Bartell SS (1997) Effects of methylphenidate and behavioral contingencies on sustained attention in attention-deficit hyperactivity disorder: a test of the reward dysfunction hypothesis. J Child Adolesc Psychopharmacol 7:123–136
Solanto MV, Abikoff H, Sonuga-Barke E, Schachar R, Logan GD, Wigal T, Hechtman L, Hinshaw S, Turkel E (2001) The ecological validity of delay aversion and response inhibition as measures of impulsivity in AD/HD: a supplement to the NIHM multimodal treatment study of AD/HD. J Abnorm Child Psychol 29:215–228
Sonuga-Barke EJS, Taylor E, Sembi S, Smith J (1992) Hyperactivity and delay aversion. I. The effect of delay on choice. J Child Psychol Psychiatry 33:387–398
Sostek AJ, Buchsbaum MS, Rapoport JL (1980) Effects of amphetamine on vigilance performance in normal and hyperactive children. J Abnorm Child Psychol 8:491–500
Spencer T, Wilens T, Biederman J, Faraone SV, Ablon JS, Lapey K (1995) A double-blind, crossover comparison of methylphenidate and placebo in adults with childhood-onset attention-deficit hyperactivity disorder. Arch Gen Psychiatry 52:434–443
Swanson JM, Volkow ND (2002) Pharmacokinetic and pharmacodynamic properties of stimulants: implications for the design of new treatments for ADHD. Behav Brain Res 130:73–78
Tannock R, Schachar RJ, Carr RP, Chajczyk D, Logan GD (1989) Effects of methylphenidate on inhibitory control in hyperactive children. J Abnorm Child Psychol 17:473–491
Trommer BL, Hoeppner JB, Zecker SG (1991) The Go-No Go test in attention deficit disorder is sensitive to methylphenidate. J Child Neurol 6[Suppl]:S128–S131
Volkow ND, Wang G, Fowler JS, Logan J, Gerasimov M, Maynard L, Ding Y, Gatley SJ, Gifford A, Franceschi D (2001) Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain. J Neurosci 21:1–5
Ward MF, Wender PH, Reimherr FW (1993) The Wender Utah rating scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry 150:885–890
Wade TR, de Wit H, Richards JB (2000) Effects of dopaminergic drugs on delayed reward as a measure of impulsive behavior in rats. Psychopharmacology 150:90–101
Wender PH, Reimherr FW, Wood D, Ward M (1985) A controlled study of methylphenidate in the treatment of attention deficit disorder, residual type, in adults. Am J Psychiatry 142:547–552
Wilkison PC, Kircher JC, McMahon WM, Sloane HN (1995) Effects of methylphenidate on reward strength in boys with attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 34:897–901
Winer BJ (1971) Statistical principles in experimental design, 2nd edn. McGraw-Hill, New York
Zachary RA, Crumptom E, Spiegel DE (1985) Estimating WAIS-R IQ from the Shipley institute of living scale. J Clin Psychol 41:532–540
Acknowledgements
This research was supported by NIH grant DA 10552 from the National Institute on Drug Abuse. The authors wish to thank Sheila White, Jennifer Sharon and Ehren Bradbury for their assistance.
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Pietras, C.J., Cherek, D.R., Lane, S.D. et al. Effects of methylphenidate on impulsive choice in adult humans. Psychopharmacology 170, 390–398 (2003). https://doi.org/10.1007/s00213-003-1547-2
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DOI: https://doi.org/10.1007/s00213-003-1547-2