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Genotoxic and mono-oxygenase system effects of the fungicide maneb

  • Genotoxicity
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Abstract.

The in vivo effects of a commercial preparation of maneb on mono-oxygenase activities of hepatic microsomes of basal and induced rats were examined. In vitro experiments with the D7 strain of yeast Saccharomyces cerevisiae were also performed. In both basal and induced rats maneb caused a decrease in cytochrome P-450 content and aniline hydroxylase. Immunoblotting analysis using anti-P-450 IIE1 antibodies confirmed the data obtained for aniline hydroxylase activity. Maneb was toxic in cells of S. cerevisiae. On the basis of in vivo and in vitro experiments it can be concluded that maneb possesses a toxic activity attributable to its main metabolite ethylene thiourea. Immunoblotting analysis indicates that maneb biotransformation influences the IIE1 P-450 isoform.

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Authors and Affiliations

  1. Dipartimento di Clinica Veterinaria, Sezione di Farmacologia e Tossicologia, Viale delle Piagge 2, 56124 Pisa, Italy, , , , ,

    Mario Giorgi & Clara Della Croce

  2. Istituto di Ispezione degli Alimenti di Origine Animale, Via del Taglio 8, 43100 Parma, Italy, , , , ,

    Simone Bertini

  3. Istituto di Mutagenesi e Differenziamento, CNR, Area della Ricerca, Via S. Cataldo, 56124 Pisa, Italy, , , , ,

    Renata Del Carratore & Giorgio Bronzetti

Authors
  1. Simone Bertini
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  2. Renata Del Carratore
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  3. Mario Giorgi
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  4. Giorgio Bronzetti
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  5. Clara Della Croce
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Bertini, S., Del Carratore, R., Giorgi, M. et al. Genotoxic and mono-oxygenase system effects of the fungicide maneb. Arch Toxicol 74, 415–420 (2000). https://doi.org/10.1007/s002040000152

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  • DOI: https://doi.org/10.1007/s002040000152

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