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2-Phenoxyethanol: a neurotoxicant? — Reply

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References

  • Ahmed AE, Jacob S, An WW (1994) Quantitative whole body autoradiographic disposition of glycol ether in mice: effect of route of administration. Fundam Appl Toxicol 22: 266–276

    Article  CAS  PubMed  Google Scholar 

  • Blevins T, Mirshahi T, Woodward JJ (1995) Increased agonist and antagonist sensitivity of N-methyl-d-aspartate stimulated calcium flux in cultured neurons following chronic ethanol exposure. Neurosci Lett 200: 214–218

    Article  CAS  PubMed  Google Scholar 

  • Bliss TVO, Collingridge GL (1993) A synaptic model of memorylong-term potentiation in the hippocampus. Nature 361: 31–39

    Article  CAS  PubMed  Google Scholar 

  • Brozowski SJ, Weiner JL, Dunwiddie TV, Whiting PJ, Harris RA (1995) Ethanol enhancement of GABA actions on cells transfected with human GABAA receptor subunit. Alcohol Clin Exp Res 19S: 8A

    Google Scholar 

  • Cain DP (1997) LTP, NMDA, genes and learning. Curr Opin Neurobiol 7: 235–242

    Article  CAS  PubMed  Google Scholar 

  • Chu B, Anantharam V, Treistman SN (1995) Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators. J Neurochem 65: 140–148

    Article  CAS  PubMed  Google Scholar 

  • Collingridge GL, Bliss TVP (1995) Memories of NMDA receptors and LTP. Trends Neurosci 18: 54–56

    Article  CAS  PubMed  Google Scholar 

  • Crews FT, Morrow AL, Criswell H, Breese G (1996) Effects of ethanol on ion channels. Int Rev Neurobiol 39: 283–367

    Article  CAS  PubMed  Google Scholar 

  • Criswell HE, Simson PE, Knapp DJ, et al (1993) Molecular basis for regionally specific action of ethanol on gamma-aminobutyric acidA receptors: generalization to other ligand-gated ion channels. J Pharmacol Exp Ther 267: 522–537

    CAS  PubMed  Google Scholar 

  • Dudek SM, Bear MF (1992) Homosynaptic long-term depression in area CAI of hippocampus and effects of N-methyl-d-aspartate receptor blockade. Proc Natl Acad Sci USA 89: 4363–4367

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Feingold CL, N'Gouemo P, Riaz A (1998) Ethanol and neurotransmitter interactions. From molecular to integrative effects. Prog Neurobiol 55: 509–535

    Article  Google Scholar 

  • Fraser AD (1996) New drugs for the treatment of epilepsy. Clin Biochem 29:97–110

    Article  CAS  PubMed  Google Scholar 

  • Hargreaves EL, Cain DP (1992) Hyperactivity, hyper-reactivity, and sensorimotor deficits induced by low doses of the N-methyl-d-aspartate non-competitive channel blocker MK-801. Behav Brain Res 47: 23–33

    Article  CAS  PubMed  Google Scholar 

  • Hargreaves RJ, Hill RG, Iversen LL (1994) Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology. Acta Neurochir (Wien) 60: 15–19

    CAS  Google Scholar 

  • Huber KM, Mauk MD, Kelly PT (1995) Distinct LTP induction mechanisms: contribution of NMDA receptors and voltage-dependent calcium channels. J Neurophysiol 73: 270–279

    CAS  PubMed  Google Scholar 

  • Hudspith MJ (1997) Glutamate: a role in normal brain function, anaesthesia, analgesia and CNS injury. Br J Anaesth 78: 731–747

    Article  CAS  PubMed  Google Scholar 

  • Larkman AU, Jack JJB (1995) Synaptic plasticity: hippocampal LTP. Curr Opin Neurobiol 5: 324–334

    Article  CAS  PubMed  Google Scholar 

  • Leeson PD, Iversen LL (1994) The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential. J Med Chem 37: 4053–4067

    Article  CAS  PubMed  Google Scholar 

  • Löscher W, Hönack D (1991) Anticonvulsant and behavioural effects of two novel competitive N-methyl-d-aspartic acid receptor antagonists, CGP37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine. J Pharmacol Exp Ther 256: 432-440

    Google Scholar 

  • Masood K, Wu C, Brauneis U, Weight FF (1994) Differential ethanol sensitivity of recombinant N-methyl-d-aspartate receptor subunits. Mol Pharmacol 45: 324–329

    CAS  PubMed  Google Scholar 

  • Meldrum BS (1995) Neurotransmission in epilepsy. Epilepsia 36 [Suppl 1]: S30–S35

    Article  PubMed  Google Scholar 

  • Mihic SJ, Ye Q, Wick MJ, et al (1997) Sites of alcohol and volatile anaesthetic action on GABA and glycine receptors. Nature 389: 385–389

    Article  CAS  PubMed  Google Scholar 

  • Morgan SL, Teyler TJ (1999) VDCCs and NMDARs underlie two forms of LTP in CAI hippocampus in vivo. J Neurophysiol 82: 736–740

    CAS  PubMed  Google Scholar 

  • Morton WE (1990) Occupational phenoxyethanol neurotoxicity: a report of three cases. J Occup Med 32: 42–45

    Article  CAS  PubMed  Google Scholar 

  • Mußhoff U, Madeja M, Binding N, Witting U, Speckmann E-J (1999) Effects of 2-phenoxyethanol on N-methyl-d-aspartate (NMDA) receptor-mediated ion currents. Arch Toxicol 73: 55–59

    Article  PubMed  Google Scholar 

  • Olney JW, Labruyere J, Price MT (1989) Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244: 1360–1362

    Article  CAS  PubMed  Google Scholar 

  • Olney JW, Labruyere J, Wang G, Wozniak DF, Price MT, Sesma MA (1991) NMDA antagonist neurotoxicity: mechanism and prevention. Science 254: 1515–1518

    Article  CAS  PubMed  Google Scholar 

  • Popp RL, Lickteig MD, Browning MD, Lovinger DM (1996) NMDA receptor subunit expression and ethanol sensitivity in cultured neurons. Alcohol Clin Exp Res 20 S: 9A

    Google Scholar 

  • Rogawski MA (1992) The NMDA receptor, NMDA antagonists and epilepsy therapy. A status report. Drugs 44: 279–292

    Article  CAS  PubMed  Google Scholar 

  • Sakimura K, Kutsuwada T, Ito I, et al (1995) Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor εl subunit. Nature 373: 151–155

    Article  CAS  PubMed  Google Scholar 

  • Tsai G, Coyle JT (1998) The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 49: 173–184

    Article  CAS  PubMed  Google Scholar 

  • Whatley VJ, Brozowski SJ, Weiner JJ, Dunwiddie TV, Whiting PJ, Harris RA (1995) A possible role of GABAA clustering in ethanol enhancement of GABAA-ergic function. Alcohol Clin Exp Res 19S: 8A

    Google Scholar 

  • Woodward JJ (1994) The effects of thiol reduction and oxidation on the inhibition of NMDA-stimulated neurotransmitter release by ethanol. Neuropharmacology 33: 635–640

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institut für Physiologie, Robert-Koch-Strasse 27a, 48149, Münster, Germany

    U. Mußhoff, M. Madeja, N. Binding, U. Witting & E-J. Speckmann

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  1. U. Mußhoff
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  2. M. Madeja
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  3. N. Binding
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  4. U. Witting
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  5. E-J. Speckmann
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Mußhoff, U., Madeja, M., Binding, N. et al. 2-Phenoxyethanol: a neurotoxicant? — Reply. Arch Toxicol 74, 284–287 (2000). https://doi.org/10.1007/s002040000111

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  • DOI: https://doi.org/10.1007/s002040000111

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