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Prolonged sedation of lorazepam due to absent UGT2B4/2B7 glucuronidation

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References

  • Chung JY, Cho JY, Yu KS, Kim JR, Lim KS, Sohn DR, Shin SG, Jang IJ (2008) Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects. Clin Pharmacol Ther 83:595–600

    Article  CAS  PubMed  Google Scholar 

  • Halama B, Hohmann N, Burhenne J, Weiss J, Mikus G, Haefeli WE (2013) A nanogram dose of the CYP3A probe substrate midazolam to evaluate drug interactions. Clin Pharmacol Ther 93:564–571

    Article  CAS  PubMed  Google Scholar 

  • Katzenmaier S, Markert C, Riedel KD, Burhenne J, Haefeli WE, Mikus G (2011) Determining the time course of CYP3A inhibition by potent reversible and irreversible CYP3A inhibitors using a limited sampling strategy. Clin Pharmacol Ther 90:666–673

    Article  CAS  PubMed  Google Scholar 

  • Miyakawa H, Kikazawa E, Abe K, Kikuchi K, Fujikawa H, Matsushita M, Kawaguchi N, Morizane T, Ohya K, Kako M (1999) Detection of anti-LKM-1(anti-CYP2D6) by an enzyme-linked immunosorbent assay in adult patients with chronic liver diseases. Autoimmunity 30:107–114

    Article  CAS  PubMed  Google Scholar 

  • Seo KA, Bae SK, Choi YK, Choi CS, Liu KH, Shin JG (2010) Metabolism of 1’- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyl-transferases 1A4, 2B4, and 2B7. Drug Metab Disp 38:2007–2013

    Article  CAS  Google Scholar 

  • Zhu B, Bush D, Doss GA, Vincent S, Franklin RB, Xu S (2008) Characterization of 1’-hydroxymidazolam glucuronidation in human liver microsomes. Drug Metab Disp 36:331–338

    Article  CAS  Google Scholar 

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Acknowledgments

We thank Monika Mauer for technical support during analytical procedures.

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No conflicts of interest are declared by any of the authors.

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Correspondence to Gerd Mikus.

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Siller, N., Egerer, G., Weiss, J. et al. Prolonged sedation of lorazepam due to absent UGT2B4/2B7 glucuronidation. Arch Toxicol 88, 179–180 (2014). https://doi.org/10.1007/s00204-013-1173-7

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  • DOI: https://doi.org/10.1007/s00204-013-1173-7

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