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Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents: possible effects of manganese superoxide dismutase (MnSOD) and 8-oxoguanine DNA glycosylase (OGG1) genes

  • Inorganic Compounds
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Abstract

Heavy metals, including arsenic and lead, may lead to cellular oxidative damage that is linked to hypertension. Manganese superoxide dismutase (MnSOD) is a scavenger of reactive oxygen species, and 8-oxoguanine DNA glycosylase (OGG1) is the major glycosylase that repairs DNA lesions. Interestingly, whether there is an elevated risk of hypertension with arsenic or lead exposure in individuals with genetic variations in MnSOD or OGG1 has not yet been investigated. Questionnaires were administered to 240 Taiwanese rural residents. Blood pressure and biochemical indicators were assessed in each subject. Urinary levels of arsenic and lead were measured with atomic absorption spectrometry; and MnSOD and OGG1 genotypes were identified via polymerase chain reaction. There was a dose–response relationship between urinary arsenic levels and risk of hypertension (P = 0.021, test for trend). However, there was no association between urinary lead levels and hypertension risk. Individuals with high urinary arsenic levels and the MnSOD Val–Ala/Ala–Ala genotypes had a greater risk of hypertension than those with low urinary arsenic levels and the MnSOD Val–Val genotype (odds ratio [OR] = 4.2, 95% confidence interval [CI] = 1.7–10.3). Subjects with a high urinary arsenic level and the OGG1 Cys–Cys genotype also had a greater risk of hypertension than those with a low urinary arsenic level and the OGG1 Ser–Ser/Ser–Cys genotypes (OR = 3.4, 95% CI = 1.1–10.7). Thus, both MnSOD and OGG1 genotypes may be prone to an increased risk of hypertension associated with arsenic exposure.

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Acknowledgments

This study was supported by a grant from Chung Shan Medical University Hospital (CSH-2010-C-11).

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Authors and Affiliations

  1. Department of Family and Community Medicine, Chung Shan Medical University Hospital, No. 110 Chien-Kuo N Rd, Sec. 1, Taichung, 40242, Taiwan

    Shiuan-Chih Chen, Chun-Chieh Chen & Ruey-Hong Wong

  2. Department of Occupational Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan

    Shiuan-Chih Chen, Chun-Chieh Chen & Ruey-Hong Wong

  3. School of Medicine, Chung Shan Medical University, Taichung, Taiwan

    Shiuan-Chih Chen & Chun-Chieh Chen

  4. Department of Public Health, Chung Shan Medical University, Taichung, Taiwan

    Chung-Yih Kuo, Chin-Hsiu Lin, Zi-Yun Lu, Yi-Yu Chen, Hong-Shen Lee & Ruey-Hong Wong

  5. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

    Chun-Huang Huang

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Correspondence to Ruey-Hong Wong.

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Chen, SC., Chen, CC., Kuo, CY. et al. Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents: possible effects of manganese superoxide dismutase (MnSOD) and 8-oxoguanine DNA glycosylase (OGG1) genes. Arch Toxicol 86, 869–878 (2012). https://doi.org/10.1007/s00204-011-0797-8

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