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A meta-analysis of studies investigating the effects of lead exposure on nerve conduction

  • Inorganic Compounds
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Abstract

Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log10 blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the median, ulnar, and radial nerves in the arm, and in the deep peroneal nerve in the leg. Distal latencies of the median, ulnar, and deep peroneal nerves were longer. No changes in the amplitudes of compound muscle or nerve action potentials were detected. The lowest concentration at which a relationship with blood lead could be detected was 33.0 μg/dl for the nerve conduction velocity of the median sensory nerve. Lead may reduce nerve conduction velocity by acting directly on peripheral nerves or by acting indirectly, for example, on the kidney or liver.

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Acknowledgments

The authors would like to thank Evelyn Palassis and Vicki Reuss for obtaining the journal articles necessary for this paper, and Monica Jackson for making copies of them.

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  1. Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-22, Cincinnati, OH, 45226, USA

    Edward F. Krieg Jr

  2. Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH, 45226, USA

    David W. Chrislip & W. Stephen Brightwell

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  1. Edward F. Krieg Jr
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  2. David W. Chrislip
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  3. W. Stephen Brightwell
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Correspondence to Edward F. Krieg Jr.

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The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health.

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Krieg, E.F., Chrislip, D.W. & Brightwell, W.S. A meta-analysis of studies investigating the effects of lead exposure on nerve conduction. Arch Toxicol 82, 531–542 (2008). https://doi.org/10.1007/s00204-008-0292-z

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