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Current status and distribution of hip fractures among older adults in China

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Abstract

Summary

China is a middle-risk country for hip fracture at present, which differs from previous data that it was low-risk. By 2050, the total number of hip fractures in people older than 65 years is predicted to be 1.3 million.

Introduction

To assess hip fracture incidence in China and examine the heterogeneity of hip fracture in seven geographical regions of China.

Methods

There were 238,230 hip fracture patients aged 65 years or older from 2013 to 2016 from a large national in-patients database (HQMS) involving 30.6 million hospitalizations. Taking into account the total national hospitalization rate per calendar year, we estimated the incidence of hip fracture per 100,000 residents older than 65 years in China overall and in seven geographical Chinese regions.

Results

The proportion of men and women older than 65 years with hip fractures was 1.00:1.95. Between 2013 and 2016, the number of hip fractures per 100,000 people age 65+ was 278. China has vast territories; the number of hip fractures per 100,000 people over 65 years old was 202 in Northeast China and 374 in Northwest China. Northwest has higher altitude, lower population density, is less developed with lower urbanization than Northeast China which is low altitude, and highly urbanized.

Conclusions

China should no longer be regarded as a low-risk country for hip fracture. By 2050, the total number of hip fractures in people older than 65 years in China is predicted to be 1.3 million. Higher altitude areas had higher hip fracture rates than lower altitude, higher urbanized areas.

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References

  1. Ström O, Borgström F, Kanis JA, Compston J, Cooper C, Mccloskey EV et al (2011) Osteoporosis: burden, health care provision and opportunities in the eu. Arch Osteoporos 6(1-2):59–155

    Article  PubMed  Google Scholar 

  2. Cauley JA, Chalhoub D, Kassem AM, Fuleihan EH (2014) Geographic and ethnic disparities in osteoporotic fractures. Nat Rev Endocrinol 10(6):338–351

    Article  PubMed  Google Scholar 

  3. Cooper C, Campion G, Melton LJ 3rd (1992) Hip fractures in the elderly: a world-wide projection. Osteoporos Int 2:285–289

    Article  CAS  PubMed  Google Scholar 

  4. Gullberg B, Johnell O, Kanis JA (1997) World-wide projections for hip fracture. Osteoporos Int 7:407–413

    Article  CAS  PubMed  Google Scholar 

  5. Cheung CL, Ang SB, Chadha M, Chow ES, Chung YS, Hew FL, Jaisamrarn U, Ng H, Takeuchi Y, Wu CH, Xia W, Yu J, Fujiwara S (2018) An updated hip fracture projection in Asia: the Asian Federation of Osteoporosis Societies study. Osteoporos Sarcopenia 4(1):16–21

    Article  PubMed  PubMed Central  Google Scholar 

  6. Kanis JA, Odén A, Mccloskey EV et al (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23(9):2239–2256

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Kannus P, Niemi S, Parkkari J, Sievanen H (2018) Continuously declining incidence of hip fracture in Finland: analysis of nationwide database in 1970–2016. Arch Gerontol Geriatr 77:64–67

    Article  PubMed  Google Scholar 

  8. Briot K, Maravic M, Roux C (2015) Changes in number and incidence of hip fractures over 12 years in France. Bone 81:131–137

    Article  PubMed  Google Scholar 

  9. Mazzucchelli Esteban R, Perez-Fernandez E, Crespí-Villarías N, García- Vadillo A, Rodriguez-Caravaca G, Gil de Miguel A et al (2017) Trends in osteoporotic hip fracture epidemiology over a 17-year period in a Spanish population: alcorco n 1999-2015. Arch Osteoporos 12:84

    Article  PubMed  Google Scholar 

  10. Michael Lewiecki E, Wright NC, Curtis JR, Siris E, Gagel RF, Saag KG, Singer AJ, Steven PM, Adler RA (2018) Hip fracture trends in the United States, 2002 to 2015. Osteoporos Int 29:717–722

    Article  PubMed  Google Scholar 

  11. Miyasaka D, Endo N, Endo E, Sakuma M, Yamamoto N, Tanabe N, Imai N, Suda K (2016) Incidence of hip fracture in Niigata, Japan in 2004 and 2010 and the long-term trends from 1985 to 2010. J Bone Miner Metab 34:92–98

    Article  PubMed  Google Scholar 

  12. Xia WB, He SL, Xu L, Liu AM, Jiang Y, Li M, Wang O, Xing XP, Sun Y, Cummings SR (2012) Rapidly increasing rates of hip fracture in Beijing, China. J Bone Miner Res 27(1):125–129

    Article  PubMed  Google Scholar 

  13. Tian FM, Zhang L, Zhao HY, Liang CY, Zhang N, Song HP (2014) An increase in the incidence of hip fractures in Tangshan, China. Osteoporos Int 25:1321–1325

    Article  PubMed  Google Scholar 

  14. Zhang C, Feng J, Wang S, Gao P, Xu L, Zhu J, Jia J, Liu L, Liu G, Wang J, Zhan S, Song C (2020) Incidence of and trends in hip fracture among adults in urban china: a nationwide retrospective cohort study. PLoS Med 17:e1003180

    Article  PubMed  PubMed Central  Google Scholar 

  15. Huang Y-M, Xu D, Long J, Shi Y, Zhang L, Wang H, Levin A, Zhao M-H (2019) Spectrum of chronic kidney disease in China: A national study based on hospitalized patients from 2010 to 2015. Nephrology (Carlton) 24(7):725–736

    Article  Google Scholar 

  16. World Population Prospects: The 2017 Revision, coming form United Nations Population Division. http://data.un.org

  17. Abrahamsen B, Vestergaard P (2010) Declining incidence of hip fractures and the extent of use of anti-osteoporotic therapy in Denmark 1997on wi. Osteoporos Int 21(3):373–380

    Article  CAS  PubMed  Google Scholar 

  18. Dimai HP, Svedbom A, Fahrleitner-Pammer A, Pieber T, Resch H, Zwettler E, Chandran M, Borgström F (2011) Epidemiology of hip fractures in Austria: evidence for a change in the secular trend. Osteoporos Int 22(2):685–692

    Article  CAS  PubMed  Google Scholar 

  19. Ettinger B, Black DM, Dawson-Hughes B, Pressman AR, Melton LJ III (2010) Updated fracture incidence rates for the US version of FRAX? Osteoporos Int 21(1):25–33

    Article  CAS  PubMed  Google Scholar 

  20. Lesnyak O, Ismailov S, Shakirova M, Alikhanova N, Kanis JA (2020) Epidemiology of hip fracture and the development of a FRAX model for uzbekistan. Arch Osteoporos 15(1):119

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Diaz-Ledezma C, Bengoa F, Dabed D, Rojas N, López A (2020) Hip fractures in the elderly Chilean population: a projection for 2030. Arch Osteoporos 15(1):116

    Article  PubMed  Google Scholar 

  22. Tamaki J, Fujimori K, Ikehara S et al (2019) Estimates of hip fracture incidence in Japan using the National Health Insurance Claim Database in 2012–2015. Osteoporos Int 30(5):975–983

    Article  CAS  PubMed  Google Scholar 

  23. Yong EL, Ganesan G, Kramer MS, Logan S, Lau TC, Cauley JA, Tan KB (2019) Hip fractures in Singapore: ethnic differences and temporal trends in the new millennium. Osteoporos Int 30(4):879–886

    Article  CAS  PubMed  Google Scholar 

  24. Tsang SWY, Kung AWC, Kanis JA, Johansson H, Oden A (2009) Ten-year fracture probability in Hong Kong Southern Chinese according to age and BMD femoral neck T-scores. Osteoporos Int 20(11):1939–1945

    Article  CAS  PubMed  Google Scholar 

  25. Tian F, Sun X, Liu J, Liu ZK, Liang CY, Zhang L (2017) Unparallel gender-specific changes in the incidence of hip fractures in Tangshan, China. Arch Osteoporos 12(1):18

    Article  PubMed  Google Scholar 

  26. Si L, Winzenberg TM, Jiang Q, Chen M, Palmer AJ (2015) Projection of osteoporosis-related fractures and costs in China 2010-2050. Osteoporos Int 26(7):1929–1937

    Article  CAS  PubMed  Google Scholar 

  27. Wang SY, Li YH, Chi GB, Xiao SY, Ozanne-Smith J, Stevenson M, Phillips MR (2008) Injury-related fatalities in China: an under-recognised public-health problem. Lancet 372(9651):1765–1773

    Article  CAS  PubMed  Google Scholar 

  28. Yang G, Wang Y, Zeng Y, Gao GF, Liang X, Zhou M, Wan X, Yu S, Jiang Y, Naghavi M, Vos T, Wang H, Lopez AD, Murray CJL (2013) Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010. Lancet 381(9882):1987–2015

    Article  PubMed  PubMed Central  Google Scholar 

  29. World Population Prospects 2019. https://population.un.org/wpp/Download/Probabilistic/Population/

  30. Kanis JA, Johnell O, Oden A, Jonsson B, de Laet C, Dawson A (2000) Risk of hip fracture according to the World Health Organization criteria for osteopenia and osteoporosis. Bone. 27(5):585–590

    Article  CAS  PubMed  Google Scholar 

  31. Kanis JA, Burlet N, Cooper C et al (2008) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 19(4):399–428

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Piscitelli P, Feola M, Rao C, Celi M, Gasbarra E, Neglia C, Quarta G, Liuni FM, Parri S, Iolascon G, Brandi ML, Distante A, Tarantino U (2014) Ten years of hip fractures in Italy: for the first time a decreasing trend in elderly women. World J Orthop 5(3):386–391

    Article  PubMed  PubMed Central  Google Scholar 

  33. Drevet S, Bioteau C, Maziu C et al (2014) Prevalence of protein-energy malnutrition in hospital patients over 75 years of age admitted for hip fracture. Orthop Traumatol Surg Res 100(6):669–674

    Article  CAS  PubMed  Google Scholar 

  34. Guo Z, Wills P, Viitanen M, Fastbom J, Winblad B (1998) Cognitive impairment, drug use, and the risk of hip fracture in persons over 75 years old: a community-based prospective study. Am J Epidemiol 148(9):887–892

    Article  CAS  PubMed  Google Scholar 

  35. Zhong BS, Qi GM, Chang YM, Zhu HM, Zhao YL, Hu ZM, Xue QY, Du J, Cheng XG (2009) IOF (China Health Promotion Foundation (CHPF); Osteoporosis Committee of China Ger- ontological Society; China Osteoporosis Foundation (COF)). https://www.iofbonehealth.org/sites/default/files/PDFs/Audit%20Asia/Asian_regional_audit_China.pdf

  36. Editorial board of Chinese white paper on osteoporosis prevention and treatment of China Health Promotion Foundation (2009) White paper on osteoporosis in China. Chin J Health Manage 3(3):148–154

  37. Zhang Y, Tang W, Zhang X, Zhang Y, Zhang L (2015) National health insurance development in China from 2004 to 2011: coverage versus benefits. PLoS ONE 10(5): e0124995.

  38. National Working Committee on Children and Women State Council, People’s Republic of China. (2018). Children in China: an Atlas of social indicators 2018. https://www.unicef.cn/en/figure-325-health-insurance-coverage-1998-2003-2008-and-2013

  39. Ueng SW, Lee SS, Lin SS, Wang CR, Liu SJ, Yang HF, Tai CL, Shih CH (1998) Bone healing of tibial lengthening is enhanced by hyperbaric oxygen therapy: a study of bone mineral density and torsional strength on rabbits. J Trauma 44(4):676–681

    Article  CAS  PubMed  Google Scholar 

  40. Stephen M, Warren MD, Douglas S et al (2001) Hypoxia regulates osteoblast gene expression. J Surg Res 99(1):147–155

    Article  CAS  Google Scholar 

  41. Uttinga J, Robinsb SP, Brandao-Burcha A et al (2006) Hypoxia inhibits the growth, diferentiation and bone-forming capacity of rat osteoblasts. Exp Cell Res 312(10):1693–1702

    Article  CAS  Google Scholar 

  42. Muzylal M, Price JS, Horton MA (2006) Hypoxia induces giant osteoclast formation and extensive bone resorption in the cat. Caleif Tissue Int 79:301–309

    Article  CAS  Google Scholar 

  43. Basu M, Malhotra AS, Pal K, Chatterjee T, Ghosh D, Haldar K, Verma SK, Kumar S, Sharma YK, Sawhney RC (2013) Determination of bone mass using multisite quantitative ultrasound and biochemical markers of bone turnover during residency at extreme altitude: a longitudinal study. High Alt Med Biol 14(2):150–154

    Article  CAS  PubMed  Google Scholar 

  44. Bozzini C, Champin GM, Alippi RM, Bozzini CE (2013) Static biomechanics in bone from growing rats exposed chronically to simulated high altitudes. High Alt Med Biol 14(4):367–374

    Article  PubMed  PubMed Central  Google Scholar 

  45. Bozzini C, Picasso EO, Champin GM, Alippi RM, Bozzini CE (2016) Structural and material mechanical quality of femoral shafts in rats exposed to simulated High Altitude from Infancy to Adulthood. High Alt Med Biol 17(1):50–53

    Article  PubMed  Google Scholar 

  46. Marks R (2010) Hip fracture epidemiological trends, outcomes, and risk factors, 1970-2009. Int J Gen Med 3:1–17

    PubMed  PubMed Central  Google Scholar 

  47. Finsen V, Benum P (1987) Changing incidence of hip fractures in rural and urban areas of central norway. Clin Orthop Relat Res 218:104–110

    Google Scholar 

  48. Chen W, Hzh L, Liu S, Liu B et al (2017) National incidence of traumatic fractures in China: a retrospective survey of 512 187 individuals. Lancet Glob Health 5(8):e807–e817

    Article  PubMed  Google Scholar 

  49. Zhu Y, Xing X, Liu S, Chen W, Zhang Y (2020) Epidemiology of low-energy wrist, hip, and spine fractures in Chinese populations 50 years or older: a national population-based survey. Medicine 99(5):e18531

    Article  PubMed  PubMed Central  Google Scholar 

  50. Ren Y, Hu J, Lu B, Zhou W, Tan B (2019) Prevalence and risk factors of hip fracture in a middle-aged and older Chinese population. Bone 122:143–149

    Article  PubMed  Google Scholar 

  51. Fang L, Gao P, Bao H, Tang X, Wang B, Feng Y et al (2018) Chronic obstructive pulmonary disease in China: a nationwide prevalence study. Lancet Respir Med 6(6):421–430

    Article  PubMed  PubMed Central  Google Scholar 

  52. Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jönsson B, Kanis JA (2013) Osteoporosis in the European Union: medical management, epidemiology and economic burden. Arch Osteoporos 8(1-2):136

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Ong T, Sahota O, Marshall L, Moran CG (2013) Re: trends in hip fracture incidence and mortality in Chinese population from Hong Kong 2001-09. Age Ageing 42(6):816–816

    Article  PubMed  Google Scholar 

  54. Prada D, Zhong J, Colicino E, Zanobetti A, Schwartz J, Dagincourt N, Fang SC, Kloog I, Zmuda JM, Holick M, Herrera LA, Hou L, Dominici F, Bartali B, Baccarelli AA (2017) Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studies. Lancet Planet Health 1:e337–e347

    Article  PubMed  PubMed Central  Google Scholar 

  55. Zhang Z, Zhu D, Cui B, Ding R, Shi X, He P (2020) Association between particulate matter air pollution and lung cancer. Thorax 75:85–87

    Article  PubMed  Google Scholar 

  56. Lin H, Qian ZM, Guo Y, Zheng Y, Ai S, Hang J, Wang X, Zhang L, Liu T, Guan W, Li X, Xiao J, Zeng W, Xian H, Howard SW, Ma W, Wu F (2018) The attributable risk of chronic obstructive pulmonary disease due to ambient ne particulate pollution among older adults. Environ Int 113:143–148

    Article  CAS  PubMed  Google Scholar 

  57. Liang F, Yang X, Liu F, Li J, Xiao Q, Chen J, Liu X, Cao J, Shen C, Yu L, Lu F, Wu X, Zhao L, Wu X, Li Y, Hu D, Huang J, Liu Y, Lu X, Gu D (2019) Long- term exposure to ambient ne particulate matter and incidence of diabetes in China: a cohort study. Environ Int 126:568–575

    Article  CAS  PubMed  Google Scholar 

  58. Griths CJ, Mudway IS (2018) Air pollution and cognition. BMJ 363:k4904

    Article  Google Scholar 

  59. United States Environmental Protection Agency, (2009). Final report: integrated science assessment for particulate matter. http://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=216546

  60. Alver K, Meyer HE, Falch JA, Sogaard AJ (2010) Outdoor air pollution, bone density and self-reported forearm fracture: the Oslo Health Study. Osteoporos Int 21:1751–1760

    Article  CAS  PubMed  Google Scholar 

  61. Qiao D, Pan J, Chen G, Xiang H, Tu R, Zhang X, Dong X, Wang Y, Luo Z, Tian H, Mao Z, Huo W, Zhang G, Li S, Guo Y, Wang C (2020) Long-term exposure to air pollution might increase prevalence of osteoporosis in Chinese rural population. Environ Res 183:109264

    Article  CAS  PubMed  Google Scholar 

  62. Deiuliis JA, Kampfrath T, Zhong J et al (2012) Pulmonary T cell activation in response to chronic particulate air pollution. Am J Phys Lung Cell Mol Phys 302:399–409

    Google Scholar 

  63. Grassi F, Tell G, Robbie-Ryan M, Gao Y, Terauchi M, Yang X, Romanello M, Jones DP, Weitzmann MN, Pacici R (2007) Oxidative stress causes bone loss in estrogen-de cient mice through enhanced bone marrow dendritic cell activation. Proc Natl Acad Sci U S A 104:15087–15092

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Moller P, Loft S (2010) Oxidative damage to DNA and lipids as biomarkers of exposure to air pollution. Environ Health Perspect 118:1126–1136

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  65. Ming-Hui Y, Xin-Bao WU, Xiao-Feng G et al (2017) Management of geriatric hip fractures:implementation of geriatric orthopedic co-management and comparison with practice in the UK. Chin J Bone Joint 6(3):169–173

    Google Scholar 

  66. Chen M, Zhang Y, Du Y et al (2019) Epidemiological and clinical study of hip fracture in hospitalized elderly patients in Shanghai, China. Arch Osteoporos 14(1):37

    Article  PubMed  Google Scholar 

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Acknowledgments

The authors thank the Bureau of Medical Administration and Medical Service Supervision, National Health and Family Planning Commission of the People’s Republic of China for the support of this study.

Funding

This study was funded by Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support, Code: ZYLX201506; Beijing Municipal Administration of Hospitals Incubating Program, Code: PX 2019015; Beijing HealthCare Project, Code: Beijing 19-17.

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Gong, X.F., Li, X.P., Zhang, L.X. et al. Current status and distribution of hip fractures among older adults in China. Osteoporos Int 32, 1785–1793 (2021). https://doi.org/10.1007/s00198-021-05849-y

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