Abstract
Summary
This is the first report describing three ipsilateral femoral stress fractures in a patient taking denosumab.
Introduction
Multiple reports of atypical femur fractures (AFF) in patients receiving denosumab have emerged recently. Denosumab is an anti-resorptive agent approved for treatment of osteoporosis. It is a human monoclonal antibody which blocks osteoclast activation, maturation, and function.
Methods
This is a case report of a 74-year-old female patient who sustained three stress fractures of her left femur.
Results
The patient healed her fractures after intramedullary nailing of the femur and was able to return to her activities.
Conclusions
High index of suspicion is needed in any patient with osteoporosis on denosumab complaining of thigh or groin pain. Careful examination and radiographic studies of both femurs are warranted if AFF is discovered.
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Hristo Piponov, Jeffrey Goldstein, and Gerald Eisenberg declare that they have no conflict of interest.
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Piponov, H.I., Goldstein, J.M. & Eisenberg, G.M. Multiple ipsilateral femoral stress fractures in a patient taking denosumab for osteoporosis—a case report. Osteoporos Int 31, 2263–2267 (2020). https://doi.org/10.1007/s00198-020-05499-6
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DOI: https://doi.org/10.1007/s00198-020-05499-6