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Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis

  • Bone Quality Seminars: Subchondral Bone
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Abstract

Osteoarthritis is a whole joint disease characterised by the disappearance of the cartilage associated with subchondral bone sclerosis, formation of osteophytes and a mild inflammation of the synovial membrane. Although all these events have been independently studied, functional interactions between these different joint tissues should exist, especially between subchondral bone and cartilage. Moreover, recent studies show that cartilage and subchondral bone act as a single functional unit. This review highlights this novel concept.

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Acknowledgments

Dr. M. Majhoub was supported by an Articulum Fellowship grant. These studies were supported by the Société Française de Rhumatologie and Arthritis Fondation Courtin.

Conflicts of interest

FB has received an honorarium for participating in a workshop sponsored by Servier.

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Authors and Affiliations

  1. UR4 “Ageing, Stress and Inflammation”, Université Pierre et Marie Curie, 7 quai Saint-Bernard, 75252, Paris Cedex 5, France

    M. Mahjoub, F. Berenbaum & X. Houard

  2. Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France

    F. Berenbaum

Authors
  1. M. Mahjoub
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  2. F. Berenbaum
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  3. X. Houard
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Correspondence to F. Berenbaum.

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Mahjoub, M., Berenbaum, F. & Houard, X. Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis. Osteoporos Int 23 (Suppl 8), 841–846 (2012). https://doi.org/10.1007/s00198-012-2161-0

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  • DOI: https://doi.org/10.1007/s00198-012-2161-0

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