Abstract
The purpose of this study was to evaluate the association between body size from birth to adulthood and bone mineral content (BMC) and bone mineral density (BMD) at the age of 31 years in a longitudinal study of the Northern Finland birth cohort for 1966. Data were collected at birth, 1, 14, and 31 years. This analysis was restricted to a subsample of individuals ( n =1,099) for whom the BMC (g) and BMD measurements (g/cm2) were performed on the distal and ultradistal radius by dual-energy X-ray absorptiometry (DXA) at the age of 31 years. Determinants of low BMC and BMD were analyzed using multivariate logistic regression. Growth retardation at birth, being underweight (BMI ≤20.0 kg/m2) at 31 years, and having a low calcium intake at 31 years were associated independently with low BMD at 31 years. Additionally, the proportion of subjects with low BMD was higher among those who had low standardized body weight (<1 SD) both at birth and at 14 years, and both at 14 and 31 years. Body weight at 31 years was the strongest associating factor of BCM at 31 years. Growth retardation at birth has long-lasting effects on adult bone mineral content and density of the distal and ultradistal radius independently of later body size, although adult body weight seems to be a most important determinant of BMC at the age of 31 years. Thinness and a low calcium intake are associated with low bone mineral content and density at 31 years of age. Further studies are needed to evaluate if these groups are at increased risk of osteoporosis in old age.
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References
van der Voort DJ, Geusens PP, Dinant GJ (2001) Risk factors for osteoporosis related to their outcome: fractures. Osteoporos Int 12:630–638
Farmer ME, Harris T, Madans JH, Wallace RB, Cornoni-Huntley J, White LR (1989) Anthropometric indicators and hip fracture. The NHANES I epidemiologic follow-up study. J Am Geriatr Soc 37:9–16
Cooper C, Cawley M, Bhalla A, Egger P, Ring F, Morton L, et al (1995) Childhood growth, physical activity, and peak bone mass in women. J Bone Miner Res 10:940–947
Cooper C, Fall C, Egger P, Hobbs R, Eastell R, Barker D (1997) Growth in infancy and bone mass in later life. Ann Rheum Dis 56:17–21
Yarbrough DE, Barrett-Connor E, Morton DJ (2000) Birth weight as a predictor of adult bone mass in postmenopausal women: the Rancho Bernardo Study. Osteoporos Int 11:626–630
Haapasalo H, Kannus P, Sievanen H, Pasanen M, Uusi-Rasi K, Heinonen A, et al (1996) Development of mass, density, and estimated mechanical characteristics of bones in Caucasian females. J Bone Miner Res 11:1751–1760
Duppe H, Cooper C, Gardsell P, Johnell O (1997) The relationship between childhood growth, bone mass, and muscle strength in male and female adolescents. Calcif Tissue Int 60:405–409
Rubin K, Schirduan V, Gendreau P, Sarfarazi M, Mendola R, Dalsky G (1993) Predictors of axial and peripheral bone mineral density in healthy children and adolescents, with special attention to the role of puberty. J Pediatr 123:863–870
Glastre C, Braillon P, David L, Cochat P, Meunier PJ, Delmas PD (1990) Measurement of bone mineral content of the lumbar spine by dual energy X-ray absorptiometry in normal children: correlations with growth parameters. J Clin Endocrinol Metab 70:1330–1333
Cooper C, Eriksson JG, Forsen T, Osmond C, Tuomilehto J, Barker DJ (2001) Maternal height, childhood growth and risk of hip fracture in later life: a longitudinal study. Osteoporos Int 12:623–629
Rantakallio P (1969) Groups at risk in low birth weight infants and perinatal mortality. Acta Paediatr Scand 193 [Suppl 193]:1–71
Rantakallio P (1968) The optimum birth weight. Ann Paediatr Fenn 14:66–70
World Health Organization (1998) Obesity preventing and managing the global epidemic. World Health Organization, Geneva
Rantakallio P (1979) Social background of mothers who smoke during pregnancy and influence of these factors on the offspring. Soc Sci Med 13A:423–429
Helsingin kaupungin tilastokeskus (1954) Sosiaaliryhmitys (Finnish). Social classification. City of Helsinki, Helsinki
Rastas M, Seppänen R (1997) Nutrient composition of foods. Social Insurance Institution, Finland
Pietinen P, Hartman AM, Haapa E, Rasanen L, Haapakoski J, Palmgren J, et al (1988) Reproducibility and validity of dietary assessment instruments. II. A qualitative food frequency questionnaire. Am J Epidemiol 128:667–676
Mannisto S, Virtanen M, Mikkonen T, Pietinen P (1996) Reproducibility and validity of a food frequency questionnaire in a case-control study on breast cancer. J Clin Epidemiol 49:401–409
Hamed HM, Purdie DW, Ramsden CS, Carmichael B, Steel SA, Howey S (1993) Influence of birth weight on adult bone mineral density. Osteoporos Int 3:1–2
Antoniades L, MacGregor AJ, Andrew T, Spector TD (2003) Association of birth weight with osteoporosis and osteoarthritis in adult twins. Rheumatology (Oxford) 42:791–796
Marriott LD, Foote KD (2003) Advances in the nutrition of preterm infants. J R Soc Health 123:159–164
Kardinaal AF, Hoorneman G, Vaananen K, Charles P, Ando S, Maggiolini M, et al (2000) Determinants of bone mass and bone geometry in adolescent and young adult women. Calcif Tissue Int 66:81–89
Kardinaal AF, Ando S, Charles P, Charzewska J, Rotily M, Vaananen K, et al (1999) Dietary calcium and bone density in adolescent girls and young women in Europe. J Bone Miner Res 14:583–592
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The Academy of Finland has participated in the funding of the collection, analysis, and interpretation of data and in the writing of the report.
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Laitinen, J., Kiukaanniemi, K., Heikkinen, J. et al. Body size from birth to adulthood and bone mineral content and density at 31 years of age: results from the northern Finland 1966 birth cohort study. Osteoporos Int 16, 1417–1424 (2005). https://doi.org/10.1007/s00198-005-1857-9
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DOI: https://doi.org/10.1007/s00198-005-1857-9