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Decreased bone mineral density at the distal radius, but not at the lumbar spine or the femoral neck, in Japanese type 2 diabetic patients

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Abstract

The purpose of this study is to assess the association between type 2 diabetes and bone mineral density. This study included 145 Japanese patients (64 men and 81 women) with type 2 diabetes and 95 non-diabetic control subjects (41 men and 54 women) of similar age. We measured bone mineral density (BMD) at the sites with different cortical/cancellous bone ratio (lumbar spine, femoral neck, and distal radius) using dual-energy X-ray absorptiometry. BMD and Z score at the distal radius were significantly lower in type 2 diabetic patients than those in control subjects, and in type 2 diabetic patients, the Z score at the distal radius was lower than that at their own lumbar spine and femoral neck. In type 2 diabetic patients, negative correlation between BMD and the mean HbA1c during the previous 2 years was found significantly at the distal radius in both genders and at the femoral neck in women. These results indicate the selective cortical bone loss in type 2 diabetes and suggest the importance of also determining BMD at the radius and keeping good metabolic control to prevent bone loss in type 2 diabetic patients.

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Acknowledgement

This work is supported by grants from Research for the Future of the Japan Society for the Promotion of Science; the Japanese Ministry of Education, Sciences, Sports, and Culture; Smoking Research Foundation and Foundation for Growth Science.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Rakuwakai Otowa Hospital, Kyoto, Japan

    T. Majima, T. Yamada, Y. Koike, M. Shigemoto, C. Takagi & I. Hatanaka

  2. Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho Sakyo-ku, 606-8507, Kyoto, Japan

    Y. Komatsu & K. Nakao

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  1. T. Majima
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Correspondence to Y. Komatsu.

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Majima, T., Komatsu, Y., Yamada, T. et al. Decreased bone mineral density at the distal radius, but not at the lumbar spine or the femoral neck, in Japanese type 2 diabetic patients. Osteoporos Int 16, 907–913 (2005). https://doi.org/10.1007/s00198-004-1786-z

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  • DOI: https://doi.org/10.1007/s00198-004-1786-z

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