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Development of cellular therapy for the treatment of stress urinary incontinence

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Abstract

Stress urinary incontinence (SUI) is highly prevalent and associated with a reduced quality of life. An intact rhabdosphincter at the mid-urethra is mandatory to maintain urinary continence. Adult stem cell injection therapy for the regenerative repair of an impaired sphincter is currently at the forefront of incontinence research. The implanted cells will fuse with muscle and release trophic factors promoting nerve and muscle integration. Hereby, we review the use of mesenchymal stem cell therapy for SUI and the experience with the development of muscle-derived stem cells.

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Conflicts of interest

Chancellor MB is the consultant and patent holder of technology licensed to Cook MyoSite, no conflicts of interest for Wang HJ and Chuang YC.

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Authors and Affiliations

  1. Department of Urology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan

    Hung-Jen Wang & Yao-Chi Chuang

  2. Department of Urology, Oakland University William Beaumont School of Medicine, Suite 438, 3535 West 13 Mile Road, Royal Oak, MI, 48073, USA

    Michael B. Chancellor

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  1. Hung-Jen Wang
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  2. Yao-Chi Chuang
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Correspondence to Michael B. Chancellor.

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This manuscript is an extended version of the Ulf Ulmsten lecture given by Dr. Michael Chancellor at the joint IUGA/ICS meeting in August 2010 in Toronto, Canada.

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Wang, HJ., Chuang, YC. & Chancellor, M.B. Development of cellular therapy for the treatment of stress urinary incontinence. Int Urogynecol J 22, 1075–1083 (2011). https://doi.org/10.1007/s00192-011-1432-1

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