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RETRACTED ARTICLE: Transurethral ultrasonography-guided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence

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This article was retracted on 25 May 2010

Abstract

In the last years preclinical studies have paved the way for the use of adult muscle derived stem cells for reconstruction of the lower urinary tract. Between September 2002 and October 2004, 42 women and 21 men suffering from urinary stress incontinence (age 36–84 years) were recruited and subsequently treated with transurethral ultrasonography-guided injections of autologous myoblasts and fibroblasts obtained from skeletal muscle biopsies. The fibroblasts were injected into the urethral submucosa, while the myoblasts were implanted into the rhabdosphincter. In parallel, 7 men and 21 women (age 39–83 years) also diagnosed with urinary stress incontinence were treated with standard transurethral endoscopic injections of collagen. Patients were randomly assigned to both groups. After a follow-up of 12 months incontinence was cured in 39 women and 11 men after injection of autologous myoblasts and fibroblasts. Mean quality of life score (51.38 preoperatively, 104.06 postoperatively), thickness of urethra and rhabdosphincter (2.103 mm preoperatively, 3.303 mm postoperatively) as well as contractility of the rhabdosphincter (0.56 mm preoperatively, 1.462 mm postoperatively) were improved postoperatively. Only in two patients treated with injections of collagen incontinence was cured. The present clinical results demonstrate that, in contrast to injections of collagen, urinary incontinence can be treated effectively with ultrasonography-guided injections of autologous myo- and fibroblasts.

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Conflict of interest statement

M. Fussenegger is co-owner of IGOR, and H. Strasser and R. Marksteiner are founders and co-owners of Innovacell Biotechnologie. Both companies run certified facilities where the autologous cells were grown. E. Margreiter, an employee of Innovacell, did most cell cultures. IGOR and Innovacell Biotechnologie had no role in study design, in the collection, analysis, and interpretation of data, in the writing of the report, or in the decision to submit the paper for publication.

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Authors and Affiliations

  1. Department of Urology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria

    H. Strasser, M. Mitterberger, G. M. Pinggera, K. Kofler & G. Bartsch

  2. Institute of Biochemical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria

    R. Marksteiner & E. Margreiter

  3. Department of Radiology II, Medical University of Innsbruck, Innsbruck, Austria

    F. Frauscher

  4. Department of Otolaryngology, Sisters of Charity Hospital, Wels, Austria

    M. Fussenegger

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  1. H. Strasser
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  5. G. M. Pinggera
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Correspondence to H. Strasser.

Additional information

This article has been retracted by the editorial board.

An erratum to this article can be found at http://dx.doi.org/10.1007/s00345-010-0568-9

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Strasser, H., Marksteiner, R., Margreiter, E. et al. RETRACTED ARTICLE: Transurethral ultrasonography-guided injection of adult autologous stem cells versus transurethral endoscopic injection of collagen in treatment of urinary incontinence. World J Urol 25, 385–392 (2007). https://doi.org/10.1007/s00345-007-0190-7

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  • DOI: https://doi.org/10.1007/s00345-007-0190-7

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