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Anticholinergic drugs, bladder retraining and their combination for urge urinary incontinence: a pilot randomised trial

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Abstract

Bladder retraining and anticholinergic drugs in women with urge urinary incontinence need to be compared. Women with urge urinary incontinence were recruited by advertisements, from primary care and from a urogynaecology clinic. Women were randomised using a web page to bladder retraining, anticholinergic drugs or both and followed up at 3 and 12 months. No blinding was attempted. The primary outcomes were the trial process and the Overactive Bladder Questionnaire (OAB-q) quality-of-life measure. Recruitment was much slower than anticipated. There were no differences in the OAB-q at 12 months (87.9 SD 11.6 bladder retraining, 81.6 SD 19.3 drug therapy and 88.9 SD 9.9 combination) but dry mouth was more common in those taking drugs. It is feasible to run a pragmatic randomised trial with 12-month follow-up for women with urinary urge incontinence. This will require about 500 participants per arm.

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Acknowledgements

Funding for this study was from an Otago Research Grant (Reference No. 200200495) from the University of Otago.

Disclosure of interests

All authors declare that they have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Women’s and Children’s Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand

    Mel Lauti, Gaye Ellis & Don Wilson

  2. Department of Preventive and Social Medicine, Dunedin School of Medicine, P.O. Box 913, Dunedin, 9054, New Zealand

    Peter Herbison

  3. Rehabilitation Teaching and Research Unit, Department of Medicine, University of Otago Wellington, Wellington, New Zealand

    Jean Hay-Smith

Authors
  1. Mel Lauti
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  2. Peter Herbison
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  3. Jean Hay-Smith
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  4. Gaye Ellis
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  5. Don Wilson
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Corresponding author

Correspondence to Peter Herbison.

Additional information

Trial registration

This trial was registered as ISRCTN 66713401.

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Lauti, M., Herbison, P., Hay-Smith, J. et al. Anticholinergic drugs, bladder retraining and their combination for urge urinary incontinence: a pilot randomised trial. Int Urogynecol J 19, 1533–1543 (2008). https://doi.org/10.1007/s00192-008-0686-8

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  • DOI: https://doi.org/10.1007/s00192-008-0686-8

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