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What’s new in sedation strategies?

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References

  1. Reade MC, Finfer S (2014) Sedation and delirium in the intensive care unit. N Engl J Med 370:444–454

    Article  CAS  PubMed  Google Scholar 

  2. Tanaka LM, Azevedo LC, Park M et al (2014) Early sedation and clinical outcomes of mechanically ventilated patients: a prospective multicenter cohort study. Crit Care 18:R156

    Article  PubMed Central  PubMed  Google Scholar 

  3. Shehabi Y, Bellomo R, Reade MC, Bailey M, Bass F, Howe B, McArthur C, Seppelt IM, Webb S, Weisbrodt L (2012) Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. Am J Respir Crit Care Med 186:724–731

    Article  PubMed  Google Scholar 

  4. Kress JP, Pohlman AS, O’Connor MF, Hall JB (2000) Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 342:1471–1477

    Article  CAS  PubMed  Google Scholar 

  5. Chlan LL, Weinert CR, Heiderscheit A, Tracy MF, Skaar DJ, Guttormson JL, Savik K (2013) Effects of patient-directed music intervention on anxiety and sedative exposure in critically ill patients receiving mechanical ventilator support: a randomized clinical trial. JAMA 309:2335–2344

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Shehabi Y, Chan L, Kadiman S, Alias A, Ismail WN, Tan MA, Khoo TM, Ali SB, Saman MA, Shaltut A, Tan CC, Yong CY, Bailey M, Sedation Practice in Intensive Care Evaluation (SPICE) Study Group Investigators (2013) Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study. Intensive Care Med 39:910–918

    Article  PubMed Central  PubMed  Google Scholar 

  7. Treggiari MM, Romand JA, Yanez ND, Deem SA, Goldberg J, Hudson L, Heidegger CP, Weiss NS (2009) Randomized trial of light versus deep sedation on mental health after critical illness. Crit Care Med 37:2527–2534

    Article  PubMed  Google Scholar 

  8. Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, Taichman DB, Dunn JG, Pohlman AS, Kinniry PA, Jackson JC, Canonico AE, Light RW, Shintani AK, Thompson JL, Gordon SM, Hall JB, Dittus RS, Bernard GR, Ely EW (2008) Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (awakening and breathing controlled trial): a randomised controlled trial. Lancet 371:126–134

    Article  PubMed  Google Scholar 

  9. Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister KE, Hall JB, Kress JP (2009) Early physical and occupational therapy in mechanical ventilated, critically ill patients: a randomised controlled trial. Lancet 373:1874–1882

    Article  PubMed  Google Scholar 

  10. Pohlman MC, Schweickert WD, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister K, Hall JB, Kress JP (2010) Feasibility of physical and occupational therapy beginning from initiation of mechanical ventilation. Crit Care Med 38:2089–2094

    Article  PubMed  Google Scholar 

  11. Mendez-Tellez PA, Dinglas VD, Colantuoni E, Ciesla N, Sevransky JE, Shanholtz C, Pronovost PJ, Needham DM (2013) Factors associated with timing of initiation of physical therapy in patients with acute lung injury. J Crit Care 28:980–984

    Article  PubMed  Google Scholar 

  12. Barr J, Fraser GL, Puntillo K, Ely WE, Gélinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R, AmericanCollegeof Critical Care Medicine (2013) Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 41:263–306

    Article  PubMed  Google Scholar 

  13. Brook AD, Ahrens TS, Schaiff R, Prentice D, Sherman G, Shannon W, Kollef MH (1999) Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. Crit Care Med 27:2609–2615

    Article  CAS  PubMed  Google Scholar 

  14. Strom Martinussen T, Toft P (2010) A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomized trial. Lancet 375:475–480

    Article  PubMed  Google Scholar 

  15. Mehta S, Burry L, Cook D, Fergusson D, Steinberg M, Granton J, Herridge M, Ferguson N, Devlin J, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Skrobik Y, Hébert P, Sabri E, Meade M, SLEAP Investigators, Canadian Critical Care Trials Group (2012) Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA 308:1985–1992

    Article  CAS  PubMed  Google Scholar 

  16. Burry L, Rose L, McCullagh IJ, Fergusson DA, Ferguson ND, Mehta S (2014) Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation. Cochrane Database Syst Rev Rev 7:CD009176

    PubMed  Google Scholar 

  17. Fraser GL, Devlin JA, Worby CP, Alhazzani W, Barr J, Dasta JF, Kress JP, Davidson JE, Spencer FA (2013) Benzodiazepine versus nonbenzodiazepine-based sedation for mechanically ventilated, critically ill adults: a systematic review and meta-analysis of randomized trials. Crit Care Med 41:S30–S38

    Article  CAS  PubMed  Google Scholar 

  18. Bioc JJ, Magee C, Cucchi J, Fraser GL, Dasta JF, Edwards RA, Devlin JW (2014) Cost effectiveness of a benzodiazepine vs. nonbenzodiazepine-based sedation regimen for mechanically ventilated, critically ill adults. J Crit Care 29:753–757

    Article  CAS  PubMed  Google Scholar 

  19. Lonardo NW, Mone MC, Nirula R, Kimball EJ, Ludwig K, Zhou X, Sauer BC, Nechodom K, Teng C, Barton RG (2014) Propofol is associated with favorable outcomes compared with benzodiazepines in ventilated intensive care unit patients. Am J Respir Crit Care Med 189:1383–1394

    Article  CAS  PubMed  Google Scholar 

  20. Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, Bratty JR, Takala J, Dexmedetomidine for Long-Term Sedation Investigators (2012) Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA 307:1151–1160

    Article  CAS  PubMed  Google Scholar 

  21. Lin YY, He B, Chen J, Wang ZN (2012) Can dexmedetomidine be a safe and efficacious agent in post-cardiac surgery patients? A meta-analysis. Crit Care 16:R169

    Article  PubMed Central  PubMed  Google Scholar 

  22. Mesnil M, Capdevila X, Bringuier S, Trine PO, Falquet Y, Charbit J, Roustan JP, Chanques G, Jaber S (2011) Long-term sedation in intensive care unit: a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam. Intensive Care Med 37:933–941

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Martin W. Dünser.

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Gradwohl-Matis, I., Mehta, S. & Dünser, M.W. What’s new in sedation strategies?. Intensive Care Med 41, 1696–1699 (2015). https://doi.org/10.1007/s00134-015-3695-3

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