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Microdialysis of the rectus abdominis muscle for early detection of impending abdominal compartment syndrome

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Abstract

Objective

To investigate whether microdialysis is capable of assessing metabolic derangements during intra-abdominal hypertension (IAH), and whether monitoring of the rectus abdominis muscle (RAM) by microdialysis represents a reliable approach in the early detection of organ dysfunctions in abdominal compartment syndrome (ACS).

Design

Prospective, randomized, controlled animal study.

Setting

University animal research facility.

Subjects

Fifteen isoflurane-anesthetized and mechanically ventilated Sprague–Dawley rats.

Interventions

IAH of 20 mmHg was induced for 3 h and followed by decompression and reperfusion for another 3-h period (n = 10). Five sham-operated animals served as controls. Microdialysis was performed in the anterior gastric wall, liver, kidney, and RAM. The anterior cervical muscles served as distant reference. Glucose, lactate, pyruvate, and glycerol was analyzed throughout the 6-h experiment.

Measurements and main results

Prolonged IAH induced significant cardiopulmonary dysfunction and persistent abdominal organ injury. Microdialysis revealed a significant increase of lactate/pyruvate and glycerol in kidney, intestine and liver, indicating ischemia, energy failure, and cell membrane damage. In addition, at 3 h IAH glucose was significantly decreased in all organs studied. The distant reference did not show any alteration of lactate/pyruvate, glycerol, and glucose over the entire 6-h observation period. In contrast to the other organs, microdialysis of the RAM showed an early and more pronounced increase of lactate, lactate/pyruvate and glycerol already at 1 h IAH. It is noteworthy that lactate, glycerol, and glucose did not completely recover upon decompression of IAH.

Conclusions

Our data suggest that continuous microdialysis in the RAM may represent a promising tool for early detecting IAH-induced metabolic derangements.

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Authors and Affiliations

  1. Institute for Clinical and Experimental Surgery, University of Saarland, Homburg/Saar, Germany

    Christoph Meier, Rene Schramm, Joerg H. Holstein, Juerg Hamacher, Michaela Amon & Michael D. Menger

  2. Division of Trauma Surgery, Department of Surgery, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland

    Christoph Meier, Guido A. Wanner & Otmar Trentz

  3. Division for Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland

    Claudio Contaldo

  4. Pulmonary Division, Internal Medicine V, University Hospital Homburg/Saar, Homburg/Saar, Germany

    Juerg Hamacher

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  1. Christoph Meier
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  2. Claudio Contaldo
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Correspondence to Christoph Meier.

Additional information

This article is discussed in the editorial available at: http://dx.doi.org/10.1007/s00134-007-0724-x.

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Meier, C., Contaldo, C., Schramm, R. et al. Microdialysis of the rectus abdominis muscle for early detection of impending abdominal compartment syndrome. Intensive Care Med 33, 1434–1443 (2007). https://doi.org/10.1007/s00134-007-0725-9

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  • DOI: https://doi.org/10.1007/s00134-007-0725-9

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