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Effects of Lanthanum on Human Lymphocytes Viability and DNA Strand Break

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Abstract

Lanthanum (La) is a rare-earth metal with applications in agriculture, industry, and medicine. Since lanthanides show a broad spectrum of applications there is an increased risk of contamination for humans. We examined the effects of lanthanum in Jurkat cells and human peripheral lymphocytes (HPL), and we found that it was cytotoxic and genotoxic on both cell lines. Additionally, HPL were more sensitive to La treatment than Jurkat cells and necrosis was the pathway by which La induced cytotoxicity. Vitamin E was able to diminish the DNA strand breaks induced suggesting that oxidative stress may be involved in the genotoxic process.

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Authors and Affiliations

  1. Radiobiology Laboratory, Institute of Radiation Protection and Dosimetry (IRD), Brazilian Nuclear Energy Commission (CNEN), SEMEX, Salvador Allende Avenue, s/no., Recreio dos Bandeirantes, Rio de Janeiro, 22780-160, RJ, Brazil

    Amanda V. Paiva, Monica S. de Oliveira, Samira N. Yunes, Leonardo G. de Oliveira & Carlos Eduardo B. de Almeida

  2. Control of Gene Expression Laboratory, Federal University of Rio de Janeiro (UFRJ), Institute of Biophysics Carlos Chagas Filho, CCS, Brigadeiro Trompovsky s/no., Ilha do Fundão, Rio de Janeiro, 21949-900, RJ, Brazil

    Amanda V. Paiva & Januário B. Cabral-Neto

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  1. Amanda V. Paiva
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  2. Monica S. de Oliveira
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  3. Samira N. Yunes
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  4. Leonardo G. de Oliveira
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  5. Januário B. Cabral-Neto
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  6. Carlos Eduardo B. de Almeida
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Correspondence to Carlos Eduardo B. de Almeida.

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Paiva, A.V., de Oliveira, M.S., Yunes, S.N. et al. Effects of Lanthanum on Human Lymphocytes Viability and DNA Strand Break. Bull Environ Contam Toxicol 82, 423–427 (2009). https://doi.org/10.1007/s00128-008-9596-1

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  • DOI: https://doi.org/10.1007/s00128-008-9596-1

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