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Regulation of wound healing and fibrosis by galectins

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Abstract

Galectins are a family of proteins with at least one carbohydrate-recognition domain. Galectins are present in various tissues and organs and participate in different physiological and pathological molecular reactions in vivo. Wound healing is the basic process of traumatic disease recovery. Wound healing involves three overlapping stages: inflammation, proliferation, and remodelling. Furthermore, a comparison of wound healing with the tumour microenvironment revealed that galectin plays a key role in the wound healing process. The current review describes the role of galectin in inflammation, angiogenesis, re-epithelialisation, and fibrous scar formation and evaluates its potential as a therapeutic drug for wounds.

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Acknowledgements

The authors acknowledge the administrative support of The Affiliated Hospital of Yangzhou University. We would like to thank the native English-speaking scientists of Editeg Company (Shanghai, China) for editing our manuscript.

Funding

This work was supported in part by the National Natural Science Foundation of China (No. 81802792).

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Authors and Affiliations

  1. Department of Traditional Chinese Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, 225000, Jiangsu, China

    Dong Yu, Ming Bu, Ping Yu, Yaping Li & Yang Chong

  2. Department of Medical College, Yangzhou University, Yangzhou, 225000, Jiangsu, China

    Dong Yu, Ming Bu, Yaping Li & Yang Chong

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D.Y., M.B., P.Y., and Y.C. conceived and designed the study. D.Y. and Y.C. drafted the manuscript. D.Y., Y.P.L., and. Y.C. drew the table and figures. All the authors were involved in revising the paper critically and gave final approval of the version to be submitted. All authors read and approved the final manuscript.

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Correspondence to Yang Chong.

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Yu, D., Bu, M., Yu, P. et al. Regulation of wound healing and fibrosis by galectins. J Mol Med 100, 861–874 (2022). https://doi.org/10.1007/s00109-022-02207-1

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