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The miRNA23b-regulated signaling network as a key to cancer development—implications for translational research and therapeutics

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Abstract

A growing body of evidence indicates that microRNA23b (miR23b) is pleiotropic—it plays important roles in regulating physiological functions of cells, in regulating differentiation of cells and in regulating cellular immune responses. Our review of the literature showed that dysregulation of miR23b expression is implicated in the disruption of these cellular mechanisms and development of diseases such as cancer. MiR23b dysregulation appears to do this by modulating the expression level of candidate gene products involved in a network of signaling pathways including TGF-beta and Notch pathways that govern malignant properties of cancer cells such as motility and invasiveness. More recently, miR23b regulation of gene expression has also been associated with cancer stem cells and chemoresistance. Our review covers miR23b’s role in immunity, endothelial function, differentiation, and cancer as well as its potential for translation into future cancer diagnostics and therapeutics.

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Acknowledgments

We would like to acknowledge support from the Delaware Bioscience Center for Advanced Technology (CAT) grant and the Cancer B Ware Foundation support. We would also like to extend our gratitude to the Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute. We thank Dr. Nicholas J. Petrelli sincerely for his help.

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  1. Department of Biological Sciences, University of Delaware, 118, Wolf Hall, Newark, DE, 19716, USA

    Vignesh Viswanathan & Bruce M. Boman

  2. Center for Translational Cancer Research, Helen F. Graham Cancer Center and Research Institute, 4701, Ogletown-Stanton Road, Suite # 4300, Newark, DE, 19713, USA

    Vignesh Viswanathan & Bruce M. Boman

  3. CA*TX Inc., Delaware Technology Park, Newark, DE, 19711, USA

    Jeremy Fields

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Viswanathan, V., Fields, J. & Boman, B.M. The miRNA23b-regulated signaling network as a key to cancer development—implications for translational research and therapeutics. J Mol Med 92, 1129–1138 (2014). https://doi.org/10.1007/s00109-014-1208-4

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