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Peripheral inflammation in neurodegeneration

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Abstract

Neuroinflammation is now a well-characterised feature of neurodegenerative diseases. Immune dysfunction outside the central nervous system is also increasingly recognised as part of the diseases. Peripheral inflammation has emerged as a modulator of disease progression and neuropathology in several neurodegenerative diseases, making it targetable in new therapeutic approaches. In addition, the easy accessibility of blood immune cells and markers makes them ideal candidates for use as possible biomarkers and a potential model of central immune cells.

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Acknowledgments

We thank Dr. Ralph Andre for his help with editing the manuscript, Dr. Jonathan M Schott for his advice on AD antibody trials and Ray Young for his help with graphics. Our work is supported financially by UCL/UCLH Biomedical Research Centre (PhD studentship to UT), BBSRC, Medical Research Council, CHDI Foundation, EU FP7 grant (Paddington consortium) and the UK Dementia and Neurodegenerative Diseases Network (DeNDRoN).

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The authors declare that they have no conflict of interests.

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  1. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK

    Ulrike Träger & Sarah J. Tabrizi

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Correspondence to Sarah J. Tabrizi.

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Träger, U., Tabrizi, S.J. Peripheral inflammation in neurodegeneration. J Mol Med 91, 673–681 (2013). https://doi.org/10.1007/s00109-013-1026-0

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