Skip to main content
Log in

Rechtsherzfunktion bei ARDS und maschineller Beatmung

Right ventricular function in ARDS and mechanical respiration

  • Schwerpunkt: Der kranke rechte Ventrikel
  • Published:
Der Internist Aims and scope Submit manuscript

Zusammenfassung

Der rechte Ventrikel ist das Stiefkind der Intensivmedizin. Bei Erkrankungen der Lunge mit vorwiegender Störung des Ventilations-Perfusions-Verhältnisses wird eine Beatmung mit positiv-endexspiratorischem Druck (PEEP) erforderlich, um die Oxygenierung zu verbessern. Die schwere Schädigung des Lungenparanchyms, wie sie bei „adult (acute) respiratory distress syndrome“ (ARDS) und Pneumonie vorgefunden wird, hat erhebliche Konsequenzen für die Herzfunktion. Während die linksventrikuläre Funktion bis in späte Stadien der Erkrankung weitestgehend unbeeinflusst bleibt, steht der rechte Ventrikel zu einem frühen Zeitpunkt durch Grunderkrankung und Beatmung unter Belastung. Die Effekte therapeutischer Maßnahmen mit der Zielstellung der Sicherung von Oxygenierung und Ventilation haben teils negative Auswirkungen auf die rechtsventrikuläre Funktion und fördern die Entwicklung eines akuten Cor pulmonale. Sie können Ursache für ein Rechtsherzversagen sein.

Abstract

The right ventricle is the stepchild of intensive care medicine. In diseases of the lung mainly when the relationship between ventilation and perfusion is disturbed, assisted respiration with positive end-expiratory pressure (PEEP) is essential to improve oxygenation. The serious damage to the lung parenchyma as seen in adult (acute) respiratory distress syndrome (ARDS) and pneumonia has considerable consequences for cardiac function. Whereas left ventricular function remains almost completely unaffected well into late stages of the disease, the right ventricle is subjected early to stress from the underlying disease and mechanical ventilation. The effects of therapeutic measures aimed at maintaining oxygenation and ventilation partially have negative consequences for right ventricular function and encourage the development of acute cor pulmonale. They can be the cause of right-sided heart failure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3

Literatur

  1. Armaganidis A (1997) Heart lung interactions during mechanical ventilation: effects on loading conditions. Intensivmedizin 34: 696–705

    Article  Google Scholar 

  2. Bellamy RF, Lowensohn HS (1980) Effect of systole on coronary pressure-flow relations in the right ventricle of the dog. Am J Physiol 238: H481–H486

    CAS  PubMed  Google Scholar 

  3. Carvalho CRR, Barbas CSV, Medeiros DM et al. (1997) Temporal hemodynamic effects of permissive hypercapnia associated with ideal PEEP in ARDS. Am J Respir Dis Crit Care Med 156: 1458–1466

    CAS  Google Scholar 

  4. Cassidy SS, Mitchell JH (1981) Effects of positive pressure breathing on right and left ventricular preload and afterload. Fed Proc 40: 2178–2181

    CAS  PubMed  Google Scholar 

  5. Dhainaut JF, Brunet F (1990) Right ventricular performance in adult respiratory distresssyndrome. Eur Respir J 3 (Suppl 11): 490s–495s

    Google Scholar 

  6. Fessler HE, Brower RG, Wise RA, Permutt S (1988) Mechanism of reduced LV afterload by systolic and diastolic positive pleural pressure. J Appl Physiol 65: 1244–1250

    CAS  PubMed  Google Scholar 

  7. Forst H, Racenberg J, Peter K, Messmer K (1988) Right ventricular performance and positive end-expiratory pressure ventilation. In: Cox W, Bihari D (eds) Shock and the adult respiratory distress syndrome. Springer, London Berlin Heidelberg New York Paris Tokio, pp 123–136

  8. Groeneveld ABJ, Berendsen RR, Schneider AJ, Pneumatikos IA, Stokkel LA, Thijs LG (2000) Effect of the mechanical ventilatory cycle on thermodilution right ventricular volumes and cardiac output. J Appl Physiol 89: 89–96

    CAS  PubMed  Google Scholar 

  9. Jardin F, Delorme G, Hardy A, Auvert B, Beaucher A, Bourdarias JP (1990) Reevaluation of hemodynamic consequences of positive pressure ventilation: emphasis on cyclic right ventricular afterloading by mechanical lung inflation. Anesthesiology 72: 966–970

    CAS  PubMed  Google Scholar 

  10. Kiely DG, Cargill RI, Lipworth BJ (1996) Effects of hypercapnia on hemodynamic, inotropic, lusitropic, and electrophysiologic indices in humans. Chest 109: 1215–1221

    CAS  PubMed  Google Scholar 

  11. Laffey JG, O’Croinin D, McLoughlin P, Kavanagh BP (2004) Permissive hypercapnia—role in protective lung ventilatory strategies. Intensive Care Med 30: 347–356

    Google Scholar 

  12. Monchi M, Bellenfant F, Cariou A et al. (1998) Early predictive factors of survival in the acute respiratory distress syndrome. Am J Respir Crit Care Med 158: 1076–1081

    CAS  PubMed  Google Scholar 

  13. Myslinski W, Mosiewicz J, Ryczak E, Barud W, Bilan A, Palushinski R, Hanzlik J (1998) Right ventricular function in systemic hypertension. J Hum Hypertens 12: 149–155

    Article  CAS  PubMed  Google Scholar 

  14. Pinsky MR, Matuschak GM, Klain M (1985) Determinants of cardiac augmentation by elevations in intrathoracic pressure. J Appl Physiol 58: 1189–1198

    CAS  PubMed  Google Scholar 

  15. Pinsky MR, Desmet JM, Vincent JL (1992) Effect of positive end-expiratory pressure on right ventricular function in humans. Am Rev Respir Dis 146: 681–687

    CAS  PubMed  Google Scholar 

  16. Pinsky MR (2002) Recent advances in the clinical application of heart-lung interactions. Curr Opin Crit Care 8: 26–31

    Article  PubMed  Google Scholar 

  17. Schmailzl KJG (1994) Kardiale Ultraschalldiagnostik. Handbuch und Atlas. Blackwell, Berlin, S 761–774

  18. Smiseth OA Thompson CR, Ling H, Robinson M, Miyagishima RT (1996) A potential clinical method for calculating transmural left ventricular filling pressure during positive end-expiratory pressure ventilation: an intraoperative study in humans. J Am Coll Cardiol 27: 155–160

    Article  CAS  PubMed  Google Scholar 

  19. Squara P, Dhainaut JFA, Artigas A, Carlet J; the European Colaborative ARDS Working Group (1998) Hemodynamic profile in severe ARDS: results of the European Collaborative ARDS Study. Intensive Care Med 24: 1018–1028

    Article  CAS  PubMed  Google Scholar 

  20. Vieillard-Baron A, Jardin F (2003) Why protect the right ventricle in patients with acute respiratory distress syndrome ? Curr Opin Crit Care 9: 15–21

    Article  PubMed  Google Scholar 

  21. Zwißler B (1993) Monitoring des rechten Ventrikels und Relevanz. Infusionsther Transfusionsmed 20: 116–120

    PubMed  Google Scholar 

Download references

Interessenkonflikt:

Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to L. Engelmann.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Engelmann, L. Rechtsherzfunktion bei ARDS und maschineller Beatmung. Internist 45, 1147–1154 (2004). https://doi.org/10.1007/s00108-004-1275-7

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00108-004-1275-7

Schlüsselwörter

Keywords

Navigation